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The Award database is continually updated throughout the year. As a result, data for the given year is not complete until April of the following year. Annual Reports data is a snapshot of agency reported information for that year and hence might look different from the live data in the Awards Information charts.

  1. Targeting the checkpoint regulator VISTA for treatment of inflammatory disease

    SBC: IMMUNEXT, INC.            Topic: R

    ImmuNext has identified and developed a putative lead anti VISTA monoclonal antibody mAb that we aim to bring to the clinic for the treatment of human autoimmune disease VISTA is a member of the highly successful negative checkpoint regulator NCR family of drug targets whose members have demonstrated proven efficacy in inducing long term remissions in human cancers We contend that antibodie ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  2. Design and Development of Immunotolerant S. aureus Biotherapies

    SBC: LYTICON, LLC            Topic: NIAID

    The increasing incidence of multi drug resistance in Staphylococcus aureus and other bacteria represents a public health crisis Two thirds of hospital associated S aureus infections and of those acquired in the community are now methicillin resistant MRSA MRSA causes andgt infections in the US each year and it is responsible for half of all US deaths caused by drug resistant bac ...

    STTR Phase II 2017 Department of Health and Human ServicesNational Institutes of Health
  3. Preclinical development of inhalable glutaredoxin-1 for the treatment of IPF

    SBC: CELDARA MEDICAL, LLC            Topic: NHLBI

    DESCRIPTION provided by applicant Idiopathic pulmonary fibrosis IPF kills about persons in the United States each year There are currently around Americans afflicted with this fatal disease that typically results in death within years This year alone another approximately Americans will receive this devastating diagnosis While two recently approved drugs reduce the ...

    SBIR Phase II 2017 Department of Health and Human ServicesNational Institutes of Health
  4. Development of GIFT4: a B cell focused immunotherapy for cancer

    SBC: CELDARA MEDICAL, LLC            Topic: NCI

    Project Summary Our goal is to develop a novel immunotherapy for the treatment of melanoma and potentially a wide array of tumors Although surveillance by the immune system eliminates cancer cells in some instances tumor cells have developed a variety of mechanisms to escape immune recognition often resulting in tumor outgrowth Immune checkpoint inhibitors e g ipilimumab nivolumab and pemb ...

    SBIR Phase II 2017 Department of Health and Human ServicesNational Institutes of Health
  5. Real-Time In-Situ Measurement of Void Fraction and Specific Surface in Fresh Concrete

    SBC: Creare LLC            Topic: 171FH2

    Water expansion during freeze-thaw cycles can cause deterioration in concrete, leading to scaling, cracking, and crumbling over a period of years. Resistance to this damage is achieved with a system of voids formed by adding surfactants to the fresh concrete to stabilize air bubbles naturally entrained during mixing. The volume fraction, size, and spacing of these voids are critical. It is importa ...

    SBIR Phase I 2017 Department of Transportation
  6. RailMonitor: Real-Time Broken Rail Detection System

    SBC: Creare LLC            Topic: 171FR2

    Broken rails are a common cause of mainline derailments and a particular concern given the increasing use of our rail system for passenger traffic and petroleum products. The progressive nature of the defects provides an opportunity for early detection of cracks before they become significant enough to cause a derailment. Unfortunately, current inspection technology does not allow these inspection ...

    SBIR Phase I 2017 Department of Transportation
  7. Improved Thermal and Acoustic Comfort for Motorcycle Helmets

    SBC: Creare LLC            Topic: 151NH1

    Use of motorcycles helmets significantly reduces the risk of fatality or serious brain injury to riders in the event of a crash, but riders often do not wear helmets in warm weather because of thermal discomfort. We propose to develop an innovative ventilation and cooling system that will maintain a cool, dry environment inside the helmet while also meeting applicable safety standards. The key the ...

    SBIR Phase II 2017 Department of Transportation
  8. PFLOTRAN Web application

    SBC: Subsurface Insights            Topic: 02b

    A key requirement for optimum use of subsurface resources is the ability to accurately simulate complex processes. Subsurface Insights will develop a wrapper around existing high end DOE modeling software which will allow commercial entities to efficiently use this software.

    SBIR Phase II 2017 Department of Energy
  9. Topic 16a- Low-Cost Desalination System Driven by Hydrokinetic Power

    SBC: Creare LLC            Topic: 16a

    Ocean and tidal currents contain a huge amount of power that is currently untapped. This power could be used very efficiently to desalinate water for water-poor regions located near coastlines. A major obstacle is the high cost of manufacturing and deployment of ocean systems. We propose an innovative new technology that can dramatically reduce the manufacturing and deployment costs of hydrokineti ...

    SBIR Phase I 2017 Department of Energy
  10. Novel Inhibitors of PSMB7 and PSMB10 for the Treatment of Multiple Myeloma

    SBC: INHIPROT, LLC            Topic: 103

    Multiple myeloma is incurable hematologic malignancy with an expected median survival of years The proteasome inhibitors bortezomib carfilzomib and the recently approved ixazomib are a mainstay of current myeloma treatment Despite an initial response rate approaching to proteasome inhibitor containing combinations all patients relapse and eventually become resistant to any treatments ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health

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