Award Data

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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until September, 2020.

  1. Topic 341: Open Scalable Software Infrastructure for Metabolomics Data

    SBC: Kitware, Inc.            Topic: NCI

    Metabolomics research has great potential, and researchers are rapidly producing new techniques for analyzing the large quantities of measurement data in order to utilize metabolomic data more effectively, including promising techniques for data integration across multiple modalities of data from mass spectrometry (MS) and nuclear magnetic resonance (NMR). However, this confluence of data growth a ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  2. pRBC Contaminant Removal with Hemocompatible Porous Polymer Beads

    SBC: CytoSorbents Medical Inc.            Topic: NHLBI

    Packed red blood cellpRBCtransfusions save livesHoweverhundreds of thousands of non hemolytic transfusion reactions occur each year worldwideranging from mild fever and pruritisto serious lifethreatening reactions such as severe hyperkalemiaanaphylaxisand transfusion related acute lung injuryTRALIMild moderate reactions drive patient discomfortdocumentationand testing costs while serious reactions ...

    SBIR Phase II 2018 Department of Health and Human Services
  3. Development and validation of therapy for mucopolysaccharidosis III

    SBC: Phoenix Nest Inc.            Topic: 103

    Project Summary Sanfilippo diseasemucopolysaccharidosis type IIIMPS IIIis a devastating neurodegenerative lysosomal storage disorder of childhood whose pathologic features are neurologicslowing of developmentsevere behavioral problemsprogressive cognitive declinedementiaand decline in motor skills leading to immobilityunresponsivenessand deathWe have focused on MPS IIID caused by a deficiency of a ...

    SBIR Phase II 2018 Department of Health and Human Services
  4. A Phase 1 Clinical Trial Evaluating the Novel Small Molecule Immuno-Oncology Antagonist SX-682 Alone and With Pembrolizumab in Metastatic Melanoma

    SBC: Syntrix Biosystems, Inc.            Topic: 102

    The chemokine receptors CXCRand CXCRCXCRare validated as having essential roles in the growthsurvivalmotilityinvasion and angiogenesis of human melanomawhich secretes abundant amounts of the corresponding chemokine ligandsincluding CXCLAdditionallyabnormal cancer induced immunosuppressive myeloid derived suppressor cellsMDSCsin the circulation and tumor correlate with melanoma stagemetastatic tumo ...

    SBIR Phase II 2018 Department of Health and Human Services
  5. An Automated Early Motor Development Risk Screener from Observational Video Recordings of Infants and Toddlers

    SBC: BSolutions Inc            Topic: NICHD

    Motor development plays a pivotal role in an infant s overall development and has a cascading effect on socialcognitivememoryand language abilityThese functions can be compromised when motor development is disruptedmotor disruption is associated with generalized developmental delaysEarly screening and identification of delays can allow early interventions with the goal of not just improving motor ...

    SBIR Phase II 2018 Department of Health and Human Services
  6. The Variant Explorer: a cloud-based data integration and visualization system for improving clinical interpretation of sequenced genetic variants.

    SBC: Solve, Inc.            Topic: 400

    Project Summary SolveBio is the operating system for molecular informationSolveBio provides data infrastructure with genomics specific mapping technology and application programming interfacesAPIsand graphical user interfacesGUIsfor scientistsbioinformaticiansand software engineersThe goal of this Phase II SBIR proposal is to develop the Variant ExplorerVEa cloud based graphical analysis software ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  7. Splice sensors for cancer drug discovery

    SBC: Lucerna Inc.            Topic: 102

    SUMMARYRNA splicing plays a central role in the generation of proteome diversity and in gene regulationSplicing impacts vital cellular processessuch as cell fate and differentiationacquisition of tissue identityand organ developmentThusdefects in splicing has been linked to many diseasesincluding spinal muscular atrophyDuchenne muscular dystrophyParkinson s diseaseand several types of cancerRNA sp ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  8. Minimally Invasive Cardiac Sympathetic Denervation for Malignant Ventricular Arrhythmia

    SBC: Coridea, LLC            Topic: NHLBI

    Sympathetic innervation of the heart plays a critical role in arrhythmogenesis and recent studies have highlighted the role of surgical sympathetic denervation in management of refractory ventricular arrhythmiasThe procedure although safe is very invasive and performed via thoracoscopy using single lung ventilationThis is not tolerated by patients with lung disease or severe structural heart disea ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  9. SpliceCore: A Cloud-Based Software Platform to Translate Alternative Splicing Events into Therapeutic Targets Using RNA-seq Data

    SBC: Envisagenics, Inc.            Topic: 400

    Abstract Overmillion people in the US suffer from genetic diseases or cancers caused by mutations of whichdisrupt the regulation of splicingAlternative splicingASerrors have been reported in literature to drivegenetic diseases out ofdescribed to dateIn additiondue to the recent success of FDA approved splicing modulators like Nusinersenalong with fascinating preclinical results underlining the imp ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  10. Expressive Speech Synthesis for Speech-Generating Devices

    SBC: SYNFONICA LLC            Topic: NIDCD

    Project SummaryThe expression of emotions through speech is an essential element of human communicationyet individuals with speech impairments who rely on speech generating devicesSGDsto talk are largely deprived of this communicative channelNo one should be forced to sound blaswhen in fact they re elated or to sound apathetic when they intend to scoldWhile certain expressive speech modes are offe ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
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