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The Award database is continually updated throughout the year. As a result, data for FY20 is not expected to be complete until September, 2021.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

  1. Topic 341: Open Scalable Software Infrastructure for Metabolomics Data

    SBC: Kitware, Inc.            Topic: NCI

    Metabolomics research has great potential, and researchers are rapidly producing new techniques for analyzing the large quantities of measurement data in order to utilize metabolomic data more effectively, including promising techniques for data integration across multiple modalities of data from mass spectrometry (MS) and nuclear magnetic resonance (NMR). However, this confluence of data growth a ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  2. STEM and Health: Science Kits Integrating STEM Concepts with Human Health

    SBC: Science Take-Out, LLC            Topic: 500

    ABSTRACT Solving human health problems often involves technologies developed through the collaborative work of scientistsengineersand mathematiciansDespite the fact that STEMsciencetechnologyengineeringand mathematicscollaboration is a crucial aspect of medical research and healthcare careersmany students are still learning scienceengineeringand math as isolated disciplinesIn additionmany teachers ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  3. A Universal Flu Vaccine Based On Conformationally Locked Soluble Headless HA

    SBC: Calder Biosciences Inc.            Topic: NIA

    An Influenza pandemic remains an acute threat to world health; and stockpiling a universally protective Influenza vaccine provides a strong defense against this potential catastrophe. The hemagglutinin (HA) protein is the primary target of humoral Ab responses to Influenza; the majority of broadly protective mAbs (bnAbs) against influenza isolated from humans recognize conserved and conformation-s ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  4. Optimization of an innate immune stimulating adjuvant for an HIV DNA vaccine

    SBC: Orlance, Inc.            Topic: NIAID

    Abstract There is a growing consensus that protection against HIV infection will require BOTH antiviral antibody responses as well as polyfunctional CDand CDT cells with potent lytic activityTo stimulate the breadthpotencyand rate of response requiredProfectus Biosciences intends to utilize its platform technologies based on DNA vaccines combined with genetic adjuvantsAs a step in that directiona ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  5. Development of Molecular Diagnostic Test for Early Onset of Lyme disease

    SBC: Bioscience Development Inc            Topic: NIAID

    Project Summary/Abstract There is no validated assay to reliably detect the early onset of the Lyme disease infection at the time when antibiotic therapy has the best chance of a cure without sequelae. Diagnosis is often difficult because most symptoms are often nebulous, with the telltale “bulls-eye” rash only appearing and clearly recognizable in approximately half of cases. The standard typ ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  6. Painless Defibrillation

    SBC: Coridea, LLC            Topic: NHLBI

    Project SummaryThe purpose of the proposed work is first-in-man testing of novel painless defibrillation (PaDe) therapy. Sudden cardiac arrest (SCA) remains the number one killer in western civilization. The underlying mechanism of SCA is usually ventricular fibrillation (VF), and survival depends on prompt defibrillation. Existing defibrillators rely on the delivery of a brief high voltage shock ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  7. pRBC Contaminant Removal with Hemocompatible Porous Polymer Beads

    SBC: CytoSorbents Medical Inc.            Topic: NHLBI

    Packed red blood cellpRBCtransfusions save livesHoweverhundreds of thousands of non hemolytic transfusion reactions occur each year worldwideranging from mild fever and pruritisto serious lifethreatening reactions such as severe hyperkalemiaanaphylaxisand transfusion related acute lung injuryTRALIMild moderate reactions drive patient discomfortdocumentationand testing costs while serious reactions ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  8. The SmartBio System for the Improved Preservation of Human Hematopoietic Stem Cells

    SBC: CELL PRESERVATION SERVICES INC            Topic: NHLBI

    Abstract The ultimate goal of cryopreservationCPis to develop a biobanking process that results in a post thaw level of cell viability and function identical to a sister population that has not undergone preservationMost methods used for the clinical level CP of human hematopoietic stem cellshHSCsand related stem cellshoweverresult in poor recovery due to post thaw necrosis and apoptosis yielding ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  9. Splice sensors for cancer drug discovery

    SBC: Lucerna Inc.            Topic: 102

    SUMMARY: RNA splicing plays a central role in the generation of proteome diversity and in gene regulation. Splicing impacts vital cellular processes, such as cell-fate and differentiation, acquisition of tissue-identity, and organ development. Thus, defects in splicing has been linked to many diseases, including spinal muscular atrophy, Duchenne muscular dystrophy, Parkinson’s disease, and sever ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  10. FMRI Dynamic Phantom for Improved Detection of Resting-State Brain Networks

    SBC: ALA SCIENTIFIC INSTRUMENTS, INC.            Topic: R44

    Abstract Functional magnetic resonance imagingfMRIhas rapidly become the dominant tool in human neuroscience researchand is poised to become a transformative technology in the areas of psychiatric and neurological diagnosticsIn recent yearslarge scale$M $B USDand long termyearinternational investmentse gNIDA Adolescent Brain Cognitive Development StudyNIH Human Connectome ProjectWhite House BRAIN ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
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