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The Award database is continually updated throughout the year. As a result, data for FY23 is not expected to be complete until September, 2024.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. Development and validation of therapy for mucopolysaccharidosis III

    SBC: Phoenix Nest Inc.            Topic: 103

    Project Summary Sanfilippo disease (mucopolysaccharidosis type III; MPS III) is a devastating neurodegenerative lysosomal storage disorder of childhood whose pathologic features are neurologic: slowing of development, severe behavioral problems, progressive cognitive decline, dementia, and decline in motor skills leading to immobility, unresponsiveness, and death. We have focused on MPS IIID cause ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  2. Sleeping Beauty Engineered B Cells for Mucopolysaccharidosis

    SBC: IMMUSOFT CORP            Topic: 300

    Project Summary Mucopolysaccharidosis type IMPS Iis an autosomal recessive storage disease caused by the absence ofL iduronidaseIDUAresulting in systemic accumulation of glycosaminoglycanGAGstorage materialshepatosplenomegalyskeletal dysplasiascardiopulmonary obstructionprogressive neurologic impairment and death by ageMPS I is currently treated by enzyme replacement therapy and by allogeneic hema ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  3. Minimally Invasive Cardiac Monitor for Neonatal and Pediatric ICU

    SBC: TRANSONIC SYSTEMS, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): Currently there exists no technology for routine measurement of cardiac output (CO) in neonates (0.4-2.5Kg) and low weight pediatric (2.5Kg+) patients in the intensive care unit (ICU). Accurate measurement of CO would a llow for better assessment of therapies and thereby improve patient health care. Conventional methods used with adults for routine CO measureme ...

    SBIR Phase II 2008 Department of Health and Human ServicesNational Institutes of Health
  4. Rapid Cystic Fibrosis Mutation Screening Test

    SBC: Pharmaseq, Inc            Topic: N/A

    DESCRIPTION (provided by applicant): We propose to configure a DNA-based assay to detect mutations in the gene related to cystic fibrosis (CF), encoding the cystic fibrosis transmembrane conductance regulator protein (CFTR). The assay will have an extende

    SBIR Phase II 2008 Department of Health and Human ServicesNational Institutes of Health
  5. Optimization and Validation of an Indicator Cell Assay for Blood-Based Diagnosis of Alzheimer's Disease

    SBC: PRECYTE INC            Topic: NIA

    Project Summary. PreCyte is developing the Indicator Cell Assay Platform (iCAP) as a broadly applicable and inexpensive blood-based assay that can be used for the early detection of disease, disease stage stratification, prognosis and predicting response to therapy for a variety of diseases. The iCAP uses cultured, standardized cells as biosensors, capitalizing on the ability of cells to respond t ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  6. Improved cleaning technology for reducing risk of transmitting infection in endoscopy.

    SBC: ADVANCED BIODEVICES LLC            Topic: R

    7. Project Summary/Abstract: Outbreaks of infection caused by contaminated endoscopes are a serious public health problem that has even resulted in patient deaths. Currently, because of the narrowness of the channels and complexity of the endoscope, there simply is no reliable way of achieving this. The existing cleaning protocols also are highly dependent on operator technique. Accordingly, this ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  7. Targeting leukocyte metabolism to treat human autoimmune disease

    SBC: Immunext, Inc.            Topic: R

    ImmuNext has defined an anti-MCT1 monoclonal antibody (mAb) that will be developed for the treatment of human autoimmune disease. The membrane monocarboxylate nutrient transporter SLC16A1 (MCT1) is a multi-pass transmembrane protein responsible for the facilitated transport of critical metabolites, including products of glycolysis: lactate, pyruvate and ketones. Our strong preliminary data support ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  8. Development of Molecular Diagnostic Test for Early Onset of Lyme disease

    SBC: Bioscience Development Inc            Topic: NIAID

    Project Summary/Abstract There is no validated assay to reliably detect the early onset of the Lyme disease infection at the time when antibiotic therapy has the best chance of a cure without sequelae. Diagnosis is often difficult because most symptoms are often nebulous, with the telltale “bulls-eye” rash only appearing and clearly recognizable in approximately half of cases. The standard typ ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  9. pRBC Contaminant Removal with Hemocompatible Porous Polymer Beads

    SBC: CYTOSORBENTS MEDICAL INC            Topic: NHLBI

    Packed red blood cell (pRBC) transfusions save lives. However, hundreds of thousands of non-hemolytic transfusion reactions occur each year worldwide, ranging from mild fever and pruritis, to serious life- threatening reactions such as severe hyperkalemia, anaphylaxis, and transfusion-related acute lung injury (TRALI). Mild-moderate reactions drive patient discomfort, documentation, and testing co ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  10. Painless Defibrillation

    SBC: Coridea, LLC            Topic: NHLBI

    Project SummaryThe purpose of the proposed work is first-in-man testing of novel painless defibrillation (PaDe) therapy. Sudden cardiac arrest (SCA) remains the number one killer in western civilization. The underlying mechanism of SCA is usually ventricular fibrillation (VF), and survival depends on prompt defibrillation. Existing defibrillators rely on the delivery of a brief high voltage shock ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
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