Award Data

DESCRIPTION (provided by applicant): The objective of this proposed project is to achieve a major transformation in the technology used to assess self-care and social disability in children and youth. Measurement and practical requirements to identify disability and evaluate individual progress across pediatric age-groups and care settings present a serious dilemma to current fixed-item instrument ...

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DESCRIPTION (provided by applicant): With its ability to secrete high levels of recombinant proteins, the yeast Pichia pastoris is extensively used for protein manufacturing. However, as actual yields vary widely for individual proteins, GlycoFi is focusing on the improvement of protein yields in P. pastoris as part of the company's long term mission to develop yeast-based protein production tech ...

DESCRIPTION (provided by applicant): N-Glycosylation has been shown to be a major factor in the overall efficacy of a therapeutic protein. However, the current inability to produce proteins with specific homogeneous N-glycan structures precludes the elucidation of structure-function relationships. Glycoproteins make up the vast majority of therapeutic proteins entering the market place. One of t ...

DESCRIPTION (provided by applicant): Vitamin B12 deficiency is a common problem that affects the general US population and the elderly in particular. The elderly are at risk for preclinical vitamin B12 deficiency due to the increased presence of B12 malabsorption and atrophic gastritis as a consequence of aging. The deficiency of vitamin B12 in the elderly has potentially serious complications inc ...

DESCRIPTION (provided by applicant): The aim of this project is to enable accurate acquisition of distortion product otoacoustic emission (DPOAE) measurements in relatively high noise environments for use in hearing evaluations and screening. DPOAE measurements have been shown to be an effective and efficient method for screening infant, child, and adult hearing. Environmental noise, however, can ...

DESCRIPTION (provided by applicant): The specific aim of this project is development of a suite of novel methods to facilitate the use of CT colonography for colorectal cancer screening. Colorectal cancer, the second leading cause of cancer-related death, can be largely prevented by early identification and removal of precursor lesions. Unfortunately, compliance with colorectal cancer screening re ...

DESCRIPTION (provided by applicant): Gastrointestinal motility disorders are a significant health problem accounting for millions of physician visits each year. In many patients, measurement of gastrointestinal transit can provide important diagnostic information. However, current transit measurement techniques involve radiation and cannot make the long-duration, highly-detailed recordings needed ...

DESCRIPTION (provided by applicant): The specific aim of this research program is to develop and transition a low-cost, liquid oxygen (LOX) generation system to support ambulatory patients using Home Oxygen Therapy (HOT). Currently in the United States, yearly expenditures on HOT are nearly two billion dollars. These expenditures will increase dramatically over the next 10 years due to the aging ...

DESCRIPTION (provided by applicant): The specific aim of this project is to develop and demonstrate a low-cost, liquid oxygen (LOX) generation system to support ambulatory patients using Home Oxygen Therapy (HOT). Currently in the United States, yearly expenditures on HOT are nearly two billion dollars. These expenditures will increase dramatically over the next ten years due to the aging baby-boo ...