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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Optimization of Protein Therapeutic Formulations

    SBC: SOLUBLE THERAPEUTICS, INC            Topic: NIGMS

    DESCRIPTION (provided by applicant): This proposal involves the development and validation of a novel approach to improve and accelerate the discovery of biopharmaceuticals (i.e. vaccines, monoclonal antibodies and other therapeutic proteins). Biopharmaceuticals are used to treat a variety of infectious and chronic diseases. The proposed research is intended to establish a new paradigm for rapidly ...

    STTR Phase I 2010 Department of Health and Human Services
  2. Fluorescence Intensity-Based Scoring of Macromolecule Crystallization Plates

    SBC: IXPRESSGENES, INC.            Topic: NIGMS

    DESCRIPTION (provided by applicant): Crystallization, followed by subsequent structure determination, is a major step in understanding the structure-function relationship of macromolecules. Understanding macromolecule structure has become a key part in the development of new pharmaceuticals, and is a major area of NIH research. Crystallization however is also the rate limiting step, despite techn ...

    STTR Phase I 2010 Department of Health and Human Services
  3. In Vivo Assessment of Embryonic Stem Cell Teratoma Prevention

    SBC: BIOINVISION INC.            Topic: NICHD

    DESCRIPTION (provided by applicant): The capacity to evaluate the teratoma forming potential of differentiated embryonic stem cell populations represents an urgent need before widespread therapeutic application of these cells is possible. Researchers at Case Western Reserve University and BioInVision, Inc. will join together to create platform technologies for validating existing embryonic stem ce ...

    STTR Phase I 2010 Department of Health and Human Services
  4. Small Molecule targeting of NADPH oxidase in neutrophils

    SBC: P2D, INC            Topic: NHLBI

    DESCRIPTION (provided by applicant): Acute lung injury (ALI) and Acute Respiratory Distress Syndrome (ARDS) are characterized by a rapid and severe respiratory failure, arising after clinical events including major surgery, trauma, multiple transfusions and sepsis. ALI/ARDS have an associated mortality of 40-80% and current pharmacological modalities have been unsuccessful in decreasing mortality. ...

    STTR Phase I 2010 Department of Health and Human Services
  5. Development of a BBB Model to Study Transendothelial Cell Migration

    SBC: FLOCEL INC.            Topic: NIMH

    DESCRIPTION (provided by applicant): Increasing evidence indicates that systemic inflammation and the blood-brain barrier (BBB), which becomes the target of overreacting or misguided immune cells that determine BBB failure and immune extravasations into the brain parenchyma, are involved in the pathogenesis of neurological diseases such as meningitis, inflammation, Alzheimer's disease, and multipl ...

    STTR Phase I 2010 Department of Health and Human Services
  6. Acute-infarct selective cardiac MRI contrast agent

    SBC: ELGAVISH PARAMAGNETICS, INC.            Topic: NHLBI

    DESCRIPTION provided by applicant The overall goal of this project is to demonstrate the ability of our acute myocardial infarct selective paramagnetic contrast agent Gadolinium ABE DTTA to differentiate between acute and chronic infarcts in a reliable manner using contrast enhanced magnetic resonance imaging ceMRI In our Phase I data we have shown that Gd ABE DTTA exclusively highlight ...

    STTR Phase II 2010 Department of Health and Human ServicesNational Institutes of Health
  7. High-Fidelity Gas and Granular Flow Physics Models for Rocket Exhaust Interaction with Lunar Soil

    SBC: CFD Research Corporation            Topic: T701

    Current modeling of Lunar and Martian soil erosion and debris transport caused by rocket plume impingement lacks essential physics from the peculiar granular characteristics of highly irregular regolith particles. Current granular mechanics models are based on mono-disperse spherical particles empiricism unsuitable for capturing the poly-disperse irregularly shaped grain mechanics. CFDRC and the U ...

    STTR Phase II 2010 National Aeronautics and Space Administration
  8. Innovative Solid State Lighting Replacements for Industrial and Test Facility Locations

    SBC: Energy Focus, Inc.            Topic: T1002

    The proposed innovation is the replacement of existing test stand and parking lot fixtures with current SSL LED technology. The replacement fixtures will reduce energy consumption, generate less heat and provide maintenance free operation for over 50,000 hours. An explosion-proof fixture is capable of containing an internal combustion event without allowing flames or hot gasses to escape to the s ...

    STTR Phase I 2010 National Aeronautics and Space Administration
  9. Microchannel Thermo Catalytic Ignition for Advanced Mono- and Bipropellants

    SBC: Plasma Processes, LLC            Topic: T301

    Small and micro-spacecrafts require the efficient, micro-propulsion systems. Chemical micro-propulsion is best suited for use as primary thrust, orbital insertion and attitude control because of its high energy density. When grouped into arrays for larger thrust applications, micro-propulsion devices provide high propulsive flexibility or can be used as igniters. The proposed effort will focus ...

    STTR Phase I 2010 National Aeronautics and Space Administration
  10. Mesh Generation and Adaption for High Reynolds Number RANS Computations

    SBC: Research South, Inc.            Topic: T801

    This proposal offers to provide NASA with an automatic mesh generator for the simulation of aerodynamic flows using Reynolds-Averages Navier-Stokes (RANS) models. The tools will be capable of generating high-quality, highly-stretched (anisotropic) grids in boundary layer regions and transition smoothly to inviscid flow regions even in an adaptive context. The objective of the work is to offer a un ...

    STTR Phase I 2010 National Aeronautics and Space Administration

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