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The Award database is continually updated throughout the year. As a result, data for FY20 is not expected to be complete until September, 2021.

  1. A Novel Microfludic Device for Drug Toxicity Studies

    SBC: CFD Research Corporation            Topic: CBD10103

    Current drug discovery and development programs are severely limited by the expensive animal trials and oversimplified in vitro models. Results obtained from the in vitro models are not predictive of in vivo toxicity owing to significant difference in testing from the in vivo physiological conditions. In this context, we propose to develop and demonstrate a novel microfluidic device for quantitati ...

    SBIR Phase I 2010 Department of DefenseOffice for Chemical and Biological Defense
  2. Microfluidic High-throughput Platform for Determining of Kinetic Constants of Enzyme Variants

    SBC: CFD Research Corporation            Topic: CBD10107

    Molecular biology techniques allow generating combinatorial libraries of large number of enzyme variants. However, there is currently no technology available for screening the enzyme libraries for identifying variants with improved activity for the substrate. We propose to develop a novel, microfluidic, high-throughput platform for determining kinetic constants of enzyme variants and identifying v ...

    SBIR Phase I 2010 Department of DefenseOffice for Chemical and Biological Defense
  3. Novel MicroPower Source for Insect Based Sensor and Communication Platforms

    SBC: CFD Research Corporation            Topic: CBD09105

    Our objective is to develop a novel micropower source to be integrated with a microsensor, and communication chip on an insect, delivering a state-of-the-art unmanned chemical detection device. The biological fuel cell (Bio-FC) power source will leverage ongoing research at CFDRC and provide a compact/lightweight power supply for mounting on numerous types of insects and producing necessary power ...

    SBIR Phase II 2010 Department of DefenseOffice for Chemical and Biological Defense
  4. Characterization and Mitigation of Radiation Effects in Quantum Dot Based Nanotechnologies

    SBC: CFD Research Corporation            Topic: DTRA082001

    For applications in DoD satellite systems, devices based on novel nanomaterials offer significant advantages over traditional technologies in terms of light-weight and efficiency. Examples of such novel devices include quantum dot (QD) based solar cells, photodetectors, radars and sensors. However, the response of these devices to radiation effects is not well understood, and radiation effects mod ...

    SBIR Phase II 2010 Department of DefenseDefense Threat Reduction Agency
  5. Characterization and Mitigation of Radiation Effects in Nonplanar Nano-technology Microelectronics

    SBC: CFD Research Corporation            Topic: DTRA092001

    Future high-performance integrated circuits in DoD satellite systems will require non-planar nano-technology devices, such as MultiGate Field Effect Transistors (MuGFET) or FinFET, which can decrease pattern area of logic circuits below 50% of the conventional planar technologies. The International Technology Roadmap for Semiconductors predicts that such devices will be the cornerstone of sub-32nm ...

    SBIR Phase I 2010 Department of DefenseDefense Threat Reduction Agency
  6. An Integrated, Electrokinetics-Augmented Microfluidic Device for Forensic DNA Analysis

    SBC: CFD Research Corporation            Topic: DTRA092003

    The use of WMDs and IEDs by covert insurgents and terrorists poses a significant risk to U.S. military forces and civilians. The capability to execute rapid forensic DNA analysis to identify individuals who manufactured and transported these threatening devices is of paramount importance to military mission, homeland security and civilian safety. Current DNA forensic analyses are time-consuming, b ...

    SBIR Phase I 2010 Department of DefenseDefense Threat Reduction Agency
  7. Electrokinetic-based Microfluidic Universal Sample-Preparation (EMUS) Platform

    SBC: CFD Research Corporation            Topic: DTRA092002

    Sample preparation has been recognized as the single most important challenge to be faced in the development of detect-to-warn (DTW) systems. Available commercial sample preparation technologies are expensive, slow, and require trained laboratory technicians and sophisticated laboratory equipment for operation. Addressing this need, we propose to design, fabricate, and demonstrate a general purpos ...

    SBIR Phase I 2010 Department of DefenseDefense Threat Reduction Agency
  8. AC Impedance Sensor for Collective Protection Filter Residual Life Indicator

    SBC: Guild Associates, Inc.            Topic: CBD10106

    Guild Associates, Inc. proposes to develop and evaluate an active electrochemical sensor based residual life indicator (RLI) for adsorptive carbon filters. The sensing system of the RLI will operate by analyzing the electrochemical state of the carbon within the filter and evaluate the remaining adsorptive reactive capacities of the filter. The sensor design will be challenged against an array of ...

    SBIR Phase I 2010 Department of DefenseOffice for Chemical and Biological Defense
  9. Next Generation Blast Simulation

    SBC: Reaction Engineering International            Topic: DTRA092015

    With the current state of world events, the threat of explosives used against high-value targets is more pronounced than ever before. As a result, simulation of blast events and their effects on structures has become an increasingly vital capability. Current blast simulations on Central Processing Units (CPU) resources require a significant amount of computational time, limiting their overall valu ...

    SBIR Phase I 2010 Department of DefenseDefense Threat Reduction Agency
  10. CBRN Sensor and Sensor Netting Algorithms

    SBC: Torch Technologies, Inc.            Topic: CBD09110

    information) During Phase I the Torch Technologies developed, demonstrated, and assessed the feasibility of an innovative, real-time multi-layered CW sensor data fusion network capability supporting advanced standoff detection and early warning against CB threats. Torch merged two significant technologies that we developed for the Department of Defense: 1) the ACRES CW multi-sensor data fusion t ...

    SBIR Phase II 2010 Department of DefenseOffice for Chemical and Biological Defense
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