Award Data

DESCRIPTION provided by applicant The overall goal of this project is to demonstrate the ability of our acute myocardial infarct selective paramagnetic contrast agent Gadolinium ABE DTTA to differentiate between acute and chronic infarcts in a reliable manner using contrast enhanced magnetic resonance imaging ceMRI In our Phase I data we have shown that Gd ABE DTTA exclusively highlight ...

For applications in DoD satellite systems, devices based on novel nanomaterials offer significant advantages over traditional technologies in terms of light-weight and efficiency. Examples of such novel devices include quantum dot (QD) based solar cells, photodetectors, radars and sensors. However, the response of these devices to radiation effects is not well understood, and radiation effects mod ...

The use of WMDs and IEDs by covert insurgents and terrorists poses a significant risk to U.S. military forces and civilians. The capability to execute rapid forensic DNA analysis to identify individuals who manufactured and transported these threatening devices is of paramount importance to military mission, homeland security and civilian safety. Current DNA forensic analyses are time-consuming, b ...

With the current state of world events, the threat of explosives used against high-value targets is more pronounced than ever before. As a result, simulation of blast events and their effects on structures has become an increasingly vital capability. Current blast simulations on Central Processing Units (CPU) resources require a significant amount of computational time, limiting their overall valu ...

Sample preparation has been recognized as the single most important challenge to be faced in the development of detect-to-warn (DTW) systems. Available commercial sample preparation technologies are expensive, slow, and require trained laboratory technicians and sophisticated laboratory equipment for operation. Addressing this need, we propose to design, fabricate, and demonstrate a general purpos ...

Current offensive solutions to neutralize chem/bio agent facilities rely on blast and/or short-burst high-temperature neutralization but have the potential to produce severe collateral damage via agent release. Our team proposes the Dispersed Energetics Coupled for Optimized Neutralization (DECON) Concept, an alternative concept to perform bulk neutralization of agents. The DECON concept can be s ...

Future high-performance integrated circuits in DoD satellite systems will require non-planar nano-technology devices, such as MultiGate Field Effect Transistors (MuGFET) or FinFET, which can decrease pattern area of logic circuits below 50% of the conventional planar technologies. The International Technology Roadmap for Semiconductors predicts that such devices will be the cornerstone of sub-32nm ...

DESCRIPTION (provided by applicant): The shortage of nurses and medical technologists is accelerating. Shortages can be reduced by scheduling staff to precisely meet the hour-by-hour demand for medical service. Think of bank teller scheduling, where more staff are scheduled at peak demand. Current attempts to schedule to demand are relatively primitive: a small number of quantized fixed shifts, fo ...

DESCRIPTION (provided by applicant): Cerebral edema (and its counterpart in the spinal cord) is a major contributor to the damage caused by stroke, traumatic brain injury, traumatic spinal-cord injury, and bacterial meningitis. Stroke alone is the third leading cause of death in the USA and the leading cause of disability. Unfortunately, few treatment options are available for cerebral and spinal- ...

DESCRIPTION (provided by applicant): In chronic wounds, numerous factors contribute to the diminished healing. Wound healing constituents, including heparan sulfate proteoglycans and numerous growth factors, are essential to normal skin wound healing. Several key growth factors such as FGF, VEGF, and PDGF require heparan sulfate-like polymers as co- receptors or co-activators for growth factor act ...