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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. SAGE LEAF 2: An Online Self-Guided Positive Emotion Regulation Program to Reduce Alzheimer's Dementia Caregiver Burden Delivered through Caregiver-Serving Organizations

    SBC: BRIGHTOUTCOME INC.            Topic: NIA

    Project Summary In the US alone, more than 11 million family caregivers provide care for someone with Alzheimer's disease or other dementia on a daily basis.1 These family caregivers have been estimated to shoulder 70% of the total cost of care over their care recipient’s lifetime, costs which include medical bills and unpaid caregiving hours.2 Caregiving-related stress contributes to social iso ...

    SBIR Phase II 2023 Department of Health and Human ServicesNational Institutes of Health
  2. Inter-alpha Inhibitors in Hypoxic-Ischemic Brain Injury

    SBC: PROTHERA BIOLOGICS, INC.            Topic: 105

    Perinatal brain injury resulting in mental retardation and cerebral palsy is the most severe disability in children and affects 40-148 in preterm and 1–2/1000 in full term infants. This places a huge burden on society, emphasizing the critical need for improved prevention/treatment strategies to decrease perinatal brain injury. Hypothermia (HT) is the only FDA approved therapy to attenuate brain ...

    SBIR Phase II 2023 Department of Health and Human ServicesNational Institutes of Health
  3. Custom Sensor Manufacturing and Regulatory Preparation Assistance for Novel Intraoperative Ureter Detection Device

    SBC: BRITESEED, LLC            Topic: NICHD

    PROJECT SUMMARY/ABSTRACT The goal of this small business innovation research grant is to commercialize a cost-effective and contrast-free intraoperative ureter detection system, which integrates into a laparoscopic vessel sealing device to identify ureters in real-time and prevent iatrogenic injuries. 70% of iatrogenic ureteral injuries are detected postoperatively, up to 30 days after hospital di ...

    SBIR Phase II 2023 Department of Health and Human ServicesNational Institutes of Health
  4. Multi-functional anti-thrombotic therapy for coronary microvascular obstruction

    SBC: APT THERAPEUTICS, INC.            Topic: NHLBI

    Principal Investigator/Program Director (Last, First, Middle: Chen, Ridong ABSTRACTAdjunctive antithrombotic treatment with dual antiplatelet therapy (aspirin + P2Y12 antagonist) plus anticoagulant (heparin or bivalirudin) is an established treatment regimen for percutaneous coronary intervention (PCI) patients. Despite aggressive antithrombotic therapy, myocardial perfusion after PCI remains inad ...

    SBIR Phase II 2023 Department of Health and Human ServicesNational Institutes of Health
  5. HgTe Colloidal Quantum Dot Imagers for Longwave Infrared Wavelengths

    SBC: QDIR, INC.            Topic: NSF2020AM

    Conventional shortwave infrared (SWIR), midwave infrared (MWIR), and long-wave (LWIR) III-V (e.g. gallium indium antimonide, or GaInSb) and II-VI (e.g. mercury cadmium telluride, or HgCdTe) epitaxial semiconductor materials show useful performance for various infrared photodetection applications, but their high-cost and substantial cooling requirements seriously limit the wide field deployment of ...

    SBIR Phase II 2023 Department of DefenseDefense Advanced Research Projects Agency
  6. Maximizing Performance of High Energy Density Liquid Rechargeable Battery PODs for Closed Cycle Energy Storage Ecosystem

    SBC: INFLUIT ENERGY LLC            Topic: NSF5371

    Energy is a critical enabling component of military operations and demand for it will continue to increase over the next few decades. Effective utilization of renewable energy could reduce demand for fuel for forward operating bases (FOBs), remote operating bases (ROBs), and expeditionary forces, and battlefields providing longer term energy solutions that support sustainment of technical superior ...

    SBIR Phase II 2022 Department of DefenseDefense Advanced Research Projects Agency
  7. Implantable Microarray Probe for Real-Time Glutamate and GABA Detection

    SBC: ALCORIX CO            Topic: 105

    Project Summary This STTR proposal will focus on developing and testing a novel, first-on-the-market implantable biosensor for in vivo, real-time sensing of gamma-aminobutyric acid (GABA) and glutamate (GLU) for animal studies. GABA and GLU are neurotransmitters (NTs) that are essential for information processing and plasticity, memory, and other functions. GLU is the major excitatory NT and GABA ...

    STTR Phase II 2023 Department of Health and Human ServicesNational Institutes of Health
  8. GEMINI: Virtual Integrative Medical Group Visitsfor Managing Chronic Pain

    SBC: BRIGHTOUTCOME INC.            Topic: NCCIH

    Abstract Chronic pain is associated with substantial suffering and other co-morbidities such as depression, insomnia, fatigue, lowered mobility, and worse quality-of-life. Most of the care of chronic pain patients occurs during hurried primary care visits with pharmacological treatments (e.g. opioids and medications) despite mixed evidence of efficacy and increased risk of potentially dangerous si ...

    SBIR Phase II 2023 Department of Health and Human ServicesNational Institutes of Health
  9. Process Development and Preclinical Advancement of a Novel Nanoparticle Formulation for Immune Activation

    SBC: SAROS THERAPEUTICS INC            Topic: NCI

    Summary Despite the success of immune checkpoint inhibitors for some types of cancer, the overall response rate remains suboptimal. The majority of solid tumors exclude T-cells (termed “cold”), thus presenting a key limiting factor for cancer immunotherapy. Activation of the cGAS-STING pathway has been demonstrated to induce anti-tumor immune responses with impressive efficacy in preclinical s ...

    SBIR Phase II 2023 Department of Health and Human ServicesNational Institutes of Health
  10. Optimizing NGF for Topical Treatment of Glaucoma

    SBC: HUMAN CELL CO            Topic: NEI

    ABSTRACTGlaucoma is a leading cause of irreversible vision loss, which is characterized by progressive degeneration of retinal ganglion cells (RGC) and their optic nerve axons. While age is a key risk factor, elevated intraocular pressure (IOP) is the only modifiable risk factor, with topical IOP-lowering drugs as the first line treatment. However, RGC degeneration and vision loss continues in hal ...

    SBIR Phase II 2023 Department of Health and Human ServicesNational Institutes of Health
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