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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. SAGE LEAF 2: An Online Self-Guided Positive Emotion Regulation Program to Reduce Alzheimer's Dementia Caregiver Burden Delivered through Caregiver-Serving Organizations

    SBC: BRIGHTOUTCOME INC.            Topic: NIA

    Project Summary In the US alone, more than 11 million family caregivers provide care for someone with Alzheimer's disease or other dementia on a daily basis.1 These family caregivers have been estimated to shoulder 70% of the total cost of care over their care recipient’s lifetime, costs which include medical bills and unpaid caregiving hours.2 Caregiving-related stress contributes to social iso ...

    SBIR Phase II 2023 Department of Health and Human ServicesNational Institutes of Health
  2. Inter-alpha Inhibitors in Hypoxic-Ischemic Brain Injury

    SBC: PROTHERA BIOLOGICS, INC.            Topic: 105

    Perinatal brain injury resulting in mental retardation and cerebral palsy is the most severe disability in children and affects 40-148 in preterm and 1–2/1000 in full term infants. This places a huge burden on society, emphasizing the critical need for improved prevention/treatment strategies to decrease perinatal brain injury. Hypothermia (HT) is the only FDA approved therapy to attenuate brain ...

    SBIR Phase II 2023 Department of Health and Human ServicesNational Institutes of Health
  3. Custom Sensor Manufacturing and Regulatory Preparation Assistance for Novel Intraoperative Ureter Detection Device

    SBC: BRITESEED, LLC            Topic: NICHD

    PROJECT SUMMARY/ABSTRACT The goal of this small business innovation research grant is to commercialize a cost-effective and contrast-free intraoperative ureter detection system, which integrates into a laparoscopic vessel sealing device to identify ureters in real-time and prevent iatrogenic injuries. 70% of iatrogenic ureteral injuries are detected postoperatively, up to 30 days after hospital di ...

    SBIR Phase II 2023 Department of Health and Human ServicesNational Institutes of Health
  4. Multi-functional anti-thrombotic therapy for coronary microvascular obstruction

    SBC: APT THERAPEUTICS, INC.            Topic: NHLBI

    Principal Investigator/Program Director (Last, First, Middle: Chen, Ridong ABSTRACTAdjunctive antithrombotic treatment with dual antiplatelet therapy (aspirin + P2Y12 antagonist) plus anticoagulant (heparin or bivalirudin) is an established treatment regimen for percutaneous coronary intervention (PCI) patients. Despite aggressive antithrombotic therapy, myocardial perfusion after PCI remains inad ...

    SBIR Phase II 2023 Department of Health and Human ServicesNational Institutes of Health
  5. Implantable Microarray Probe for Real-Time Glutamate and GABA Detection

    SBC: ALCORIX CO            Topic: 105

    Project Summary This STTR proposal will focus on developing and testing a novel, first-on-the-market implantable biosensor for in vivo, real-time sensing of gamma-aminobutyric acid (GABA) and glutamate (GLU) for animal studies. GABA and GLU are neurotransmitters (NTs) that are essential for information processing and plasticity, memory, and other functions. GLU is the major excitatory NT and GABA ...

    STTR Phase II 2023 Department of Health and Human ServicesNational Institutes of Health
  6. GEMINI: Virtual Integrative Medical Group Visitsfor Managing Chronic Pain

    SBC: BRIGHTOUTCOME INC.            Topic: NCCIH

    Abstract Chronic pain is associated with substantial suffering and other co-morbidities such as depression, insomnia, fatigue, lowered mobility, and worse quality-of-life. Most of the care of chronic pain patients occurs during hurried primary care visits with pharmacological treatments (e.g. opioids and medications) despite mixed evidence of efficacy and increased risk of potentially dangerous si ...

    SBIR Phase II 2023 Department of Health and Human ServicesNational Institutes of Health
  7. Process Development and Preclinical Advancement of a Novel Nanoparticle Formulation for Immune Activation

    SBC: SAROS THERAPEUTICS INC            Topic: NCI

    Summary Despite the success of immune checkpoint inhibitors for some types of cancer, the overall response rate remains suboptimal. The majority of solid tumors exclude T-cells (termed “cold”), thus presenting a key limiting factor for cancer immunotherapy. Activation of the cGAS-STING pathway has been demonstrated to induce anti-tumor immune responses with impressive efficacy in preclinical s ...

    SBIR Phase II 2023 Department of Health and Human ServicesNational Institutes of Health
  8. Optimizing NGF for Topical Treatment of Glaucoma

    SBC: HUMAN CELL CO            Topic: NEI

    ABSTRACTGlaucoma is a leading cause of irreversible vision loss, which is characterized by progressive degeneration of retinal ganglion cells (RGC) and their optic nerve axons. While age is a key risk factor, elevated intraocular pressure (IOP) is the only modifiable risk factor, with topical IOP-lowering drugs as the first line treatment. However, RGC degeneration and vision loss continues in hal ...

    SBIR Phase II 2023 Department of Health and Human ServicesNational Institutes of Health
  9. Data-Driven Software to Automate Top-Down Mass Spectrometry of Large Molecules

    SBC: PROTEINACEOUS, INC.            Topic: 400

    PROJECT SUMMARY Analysis of intact proteins by top-down mass spectrometry enables direct measurement of the specific sequences and posttranslational modifications that drive biological processes, disease, and protein therapeutic attributes. Despite the potential that top-down mass spectrometry has for protein analytics, acquiring high- quality data and then interpreting the data requires significa ...

    SBIR Phase II 2023 Department of Health and Human ServicesNational Institutes of Health
  10. Production of Natural Deoxysugars for Use in Chemical Synthesis of Glycosides

    SBC: MIDWEST BIOPROCESSING CENTER LLC            Topic: 300

    Project SummaryThe goal of the proposal presented herein is to produce naturally occurring 6-deoxysugars, including di- and tri-deoxysugars, amino sugars and branched-chain sugars. These specialized hexoses are found as important structural components throughout plant and microbial secondary metabolites, often playing a crucial role in conferring activity in bioactive natural products, such as ant ...

    SBIR Phase II 2023 Department of Health and Human ServicesNational Institutes of Health
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