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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Randomized Prospective Phase II Clinical Trial of NVX in Association with Chemoradiation of Glioblastoma

    SBC: NUVOX PHARMA, L.L.C.            Topic: 102

    Glioblastoma multiforme GBM is a malignant primary brain tumor affecting about new cases per year in the U S Average survival is only about months Radiation RT is most commonly administered as fractions of Gray each over weeks with concomitant temozolomide TMZ GBM tumors are hypoxic The primary mechanism of RT is creation of singlet oxygen hypoxia within GBM adversel ...

    SBIR Phase II 2017 Department of Health and Human ServicesNational Institutes of Health
  2. Development and evaluation of an internet based adaptation of the New Beginnings Program for divorced parents

    SBC: Family Transitions- Programs that Work, LLC            Topic: NICHD

    PROJECT ABSTRACT The proposed research builds on a successful Phase I SBIR grant to develop and test a web based version of a parenting after divorce group interventionthe New Beginnings Programwhich has been shown in two randomized trials to reduce youthsproblem behaviors and enhance their developmental competencies in theyear period after their parents participatedThe proposed web based format w ...

    SBIR Phase II 2018 Department of Health and Human Services
  3. Dual View Endoscopy for Colonoscopy

    SBC: Omniscient Imaging, Inc.            Topic: 102

    AbstractAn estimatedmillion colonoscopies are performed annually in the US at a cost of about $Bhowever current colonoscopes with forward vision fail to detectof precancerous polypsOverof the missed polyps are located on or behind numerous folds in the colon where they are hidden from the sight of a forward view colonoscopeIn this research proposalwe propose to complete our development of an imagi ...

    STTR Phase II 2018 Department of Health and Human Services
  4. Tools and Methods for Producing High Quality Functional Protein Microarrays for Biomarker Discovery

    SBC: INanoBio, Inc.            Topic: 100

    AbstractFunctional protein microarrays find applications in high throughput disease biomarker discoveryunderstanding the incidence and role of post translational modificationsPTMsin disease pathologyinvestigating activity and function of enzymesprotein protein and proteinsmall molecule interactionsamong othersNucleic Acid Programmable Protein ArrayNAPPAtechnology is a robust method for producing c ...

    SBIR Phase I 2018 Department of Health and Human Services
  5. Lab-To-Marketplace: Commercialization of a stretchable microelectrode array

    SBC: BMSEED LLC            Topic: NINDS

    Project Summary Abstract The proposed work is directed at the commercialization of BMSEEDandapos s Micro Electrode Array Stretching Stimulating und Recording EquipmentMEASSuREtechnologyMEASSuRE bridges the gap between in vitro and in vivo research by simulating the biomechanical and electrical environment of cells in the body in a controlled environment outside of the bodyThe applications for MEAS ...

    SBIR Phase II 2018 Department of Health and Human Services
  6. Pancreatic Ductal Adenocarcinoma Targeted Ultrasound Contrast Agent Development

    SBC: NUVOX PHARMA, L.L.C.            Topic: 102

    Pancreatic ductal adenocarcinomaPDACis a highly lethal form of cancerIn most patientsdetection is at an advanced stage and the outcome is poorThis project is directed towards development of a molecularly targeted ultrasound contrast agent with potential to detect early stage disease while still curableIn Phase I of this projectwe incorporated the engineered human single chain variable fragmentscFv ...

    SBIR Phase II 2018 Department of Health and Human Services
  7. An Integrated Microarray Printing and Detection System

    SBC: BIOSENSING INSTRUMENT INC            Topic: 400

    DESCRIPTIONprovided by applicantMicroarray technology has dramatically advanced the study of protein interactions leading to discovery and validation of new biomarkers and therapeutic drugsTypicallyprotein microarrays are pre spotted with target molecules in one device and then tested with probe molecules using another deviceDuring each testing cyclethe entire microarray becomes exposed to the pro ...

    SBIR Phase II 2017 Department of Health and Human Services
  8. 4D Acoustoelectric Cardiac Imaging for Fast and Accurate Mapping of Arrhythmias

    SBC: ElectroSonix LC            Topic: NHLBI

    Abstract Despite global success of interventional cardiac surgery for treatment of arrhythmiaselectroanatomical mappingEAMof the heart has significant drawbacksThe procedure is slow and prone to registration errorslargely ineffective for treating transient arrhythmiassuch as ventricular tachycardiaand exhibits relatively poor spatial resolutionWith only asuccess rate for first time interventionsth ...

    SBIR Phase I 2018 Department of Health and Human Services
  9. GAA-ITEM: Personalizing the Prediction of Anti-therapeutic Antibody Response in Pompe Disease Patients

    SBC: EPIVAX, INC.            Topic: 999

    Abstract SignificanceInfantile Pompe DiseaseIPDis an autosomal recessive glycogen storage disorder caused by a deficiency of acid alpha glucosidaseGAAleading to accumulation of glycogen in lysosomesprimarily in skeletalcardiac and smooth musclesUntreated IPD infants die within the firstyears of lifeEnzyme replacement therapyERTwith recombinant human GAArhGAAimproves survival and quality of lifebut ...

    SBIR Phase I 2018 Department of Health and Human Services
  10. Mobile multifunctional tool for monitoring and management of respiratory diseases

    SBC: TF HEALTH CORPORATION            Topic: NHLBI

    DESCRIPTION provided by applicant Mobile multifunctional tool for monitoring and management of respiratory diseases Chronic Obstructive Pulmonary Disease COPD and asthma affect millions of people worldwide Because there is no permanent cure for these diseases efficient management of the patients is needed New mobile health technologies such as personal devices that allow patients to monit ...

    SBIR Phase II 2015 Department of Health and Human ServicesNational Institutes of Health

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