List

This proposal responds to RFA DCin which the NIDCD is seeking to support the development of acoustic signal processing tools that have the potential to accelerate research studies and to facilitate the translation of novel algorithms for hearing aidsApproximatelyof American adults report some degree of hearing troubleandof Americans agedand over experience bilateral hearing lossHLThehearing aid in ...

ImmuNext has defined an anti MCTmonoclonal antibodymAbthat will be developed for the treatment of human autoimmune diseaseThe membrane monocarboxylate nutrient transporter SLCAMCTis a multi pass transmembrane protein responsible for the facilitated transport of critical metabolitesincluding products of glycolysislactatepyruvate and ketonesOur strong preliminary data support the tenet that mAbs tha ...

The military combat eye protection (MCEP) program is designed to protect our soldiers' eyes from the external threats of fragmentation, electromagnetic radiation, wind, dust, sand, etc. and greatly improve both safety and operational effectiveness. However, the goggles and spectacles on the Militarys authorized protective eyewear list (APEL) are only effective if the soldier is wearing them. Foggi ...

PROJECT SUMMARY This Phase II Lab to Marketplace proposal aims to commercialize a new remote focusing technique that can change the focus of a microscope by as much asm in less thansorders of magnitude faster than other discrete focus change techniquesOur initial market is neuroscience imagingwhere the ability of researchers to step between focal planes at the millisecond timescale of neuronal cir ...

PROJECT SUMMARY ABSTRACT The National Research Council recognizes that serious computer games can support new inquiry based approaches to science instructionproviding virtual laboratories or field learning experiences that overcome practical and logistical constraints to student investigationsWith the nationally recognized need to encourage and enhance education in the ScienceTechnologyEngineering ...

PROJECT SUMMARY ABSTRACTMillions of children around the globe are afflicted with conditions that can alter neuropsychological developmentincluding human immunodeficiency virusHIVtraumatic brain injuryTBIcerebral malariaand a host of other developmental and acquired diseases and disordersEarly assessment and intervention are critical in overcoming cognitive and developmental deficiencies and are in ...

AbstractA major shortfall in clinical care for diabetes is a rapid and accurate screen for progression to diseaseCurrent criteria involve HLA haplotypeand the presence of auto antibodiesAAGenome wide associated studiesGWASrevealed only immune associated genes including HLA as T D predictorsThe ability to differentiate from other diseases was very limitedPre typediabetesp T Dis now being identified ...

Project SummaryAbstract Dental caries are the most common childhood disease in the United StatesDental sealants are materials that are applied to the pits and fissures of healthy teeth to prevent dental caries or other forms of decayThis method prevents bacteria ingress and acid dissolution and targets the portions of the tooth surface whereof the decay developsSealants are safe and effective in p ...

SUMMARY Chronic skin wounds associated with various diseasese gdiabetesand aberrant healing from acute woundinge ghypertrophic scarringare a major health care burdenThis health burden increases in aging populationsThe cost to treat these conditions exceeds $billion annuallyCurrentlyREGRANEXa cream containing a biologic based on human PDGFPlatelet Derived Growth Factoris the only FDAFood and Drug A ...

Driving while intoxicatedDWIremains a substantial and preventable source of morbidity and mortality in the United StatesA variety of sanctions and interventions have been attempted to reduce DWI in the U Sincluding enhanced DWI enforcement effortsstricter drunk driving lawsresponsible alcohol beverage service trainingand alcohol treatmentThe Ignition Interlock DeviceIIDwhich requires a driver to b ...