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ImmuNext has defined an anti-MCT1 monoclonal antibody (mAb) that will be developed for the treatment of human autoimmune disease. The membrane monocarboxylate nutrient transporter SLC16A1 (MCT1) is a multi-pass transmembrane protein responsible for the facilitated transport of critical metabolites, including products of glycolysis: lactate, pyruvate and ketones. Our strong preliminary data support ...

Project Summary TopoGENin a strategic partnership with Nanoly Bioscienceproposes to develop ambient condition stable Research Use OnlyRUOproductse genzymesantibodiesand Kitsthrough the use of a syntheticsafeand biocompatible polymer encapsulation technologyNanoShieldNanoShield uses a patent protected photodegradable polyethylene glycolPEGhydrogel network to encapsulate and shield sensitive biomole ...

Health disparities are high among LatinasThey are more likely to be overweightdiagnosed with diabetesand physically inactive compared to their non Hispanic White counterpartsThusinterventions that target improving health access and ameliorating chronic diseases among Latinas are of high public health importanceAvailable data suggest that community focused interventions produce improvements in phys ...

Project Summary Microscopy with spatial light modulatorsSLMsenables use of optical techniques to simultaneously monitor and manipulate the activity of neuronal ensemblesin vitro and in vivoAs a result of successful worldwide research in this fieldsuppliers of commercial two photon microscopes feel there is extensive product potentialAs suchthree commercial microscope suppliers have licensed patent ...

PROJECT SUMMARY This Phase II Lab-to-Marketplace proposal aims to commercialize a new remote focusing technique that can change the focus of a microscope by as much as 500 μm in less than 40 μs, 3 orders of magnitude faster than other discrete focus change techniques. Our initial market is neuroscience imaging, where the ability of researchers to step between focal planes at the millisecond time ...

Project Summary AbstractDevelopment of a Nerve Cuff Electrode from Soft and Elastomeric Conducting Wires STTR Phase I ApplicationPIBrady ClapsaddleTDA ResearchIncBio electronic interfaces are used in a wide array of applications for recording and providing electrical impulses to treat diseaseOne common interface device for the PNS is the cuff electrodeCurrent cuff electrodes have many failure mode ...

PROJECT SUMMARY ABSTRACT The National Research Council recognizes that serious computer games can support new inquiry based approaches to science instructionproviding virtual laboratories or field learning experiences that overcome practical and logistical constraints to student investigationsWith the nationally recognized need to encourage and enhance education in the ScienceTechnologyEngineering ...

PROJECT SUMMARY ABSTRACTMillions of children around the globe are afflicted with conditions that can alter neuropsychological developmentincluding human immunodeficiency virusHIVtraumatic brain injuryTBIcerebral malariaand a host of other developmental and acquired diseases and disordersEarly assessment and intervention are critical in overcoming cognitive and developmental deficiencies and are in ...

AbstractA major shortfall in clinical care for diabetes is a rapid and accurate screen for progression to diseaseCurrent criteria involve HLA haplotypeand the presence of auto antibodiesAAGenome wide associated studiesGWASrevealed only immune associated genes including HLA as T D predictorsThe ability to differentiate from other diseases was very limitedPre typediabetesp T Dis now being identified ...

Project SummaryAbstract Dental caries are the most common childhood disease in the United StatesDental sealants are materials that are applied to the pits and fissures of healthy teeth to prevent dental caries or other forms of decayThis method prevents bacteria ingress and acid dissolution and targets the portions of the tooth surface whereof the decay developsSealants are safe and effective in p ...