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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Detection and Staging of Liver Fibrosis by Precise MRI (pMRI)


    Abstract Chronic liver injury due to alcoholmetabolic dysfunctionviral hepatitisor autoimmune disease results in liver inflammation and fibrosisLiver fibrosis will progress to cirrhosis which is estimated to affectof the world s populationThe major clinical consequences of cirrhosis are liver failure and hepatocellular carcinomaHCCboth of which increase the risk of deathAlcoholic liver diseaseALDi ...

    STTR Phase II 2018 Department of Health and Human Services
  2. High-specificity affinity reagents for the detection of glycan sialylation


    PROJECT SUMMARY Glycans have several distinct properties that make them potential disease biomarkersFirstlytheir location on cell surfaces makes them the first point of contact for cellular interactionsand thus they are crucial in the control of normal metabolic processesSecondlycell surface molecules are strategically exposed for surveillance by the immune systemwhere they may serve as immune rec ...

    SBIR Phase II 2018 Department of Health and Human Services
  3. Development of a protein drug for pancreatic cancer treatment

    SBC: ProDa BioTech L.L.C.            Topic: NCI

    Abstract Pancreatic cancers are devastating diseases with five year survival rate less thanCurrentlythere is no effective treatment for advanced diseaseOne major barrier to efficacy of anti tumor therapeutics is the dense desmoplastic stromal responseEvidence suggests that cancer associated pancreatic stellate cellsCAPaSCproduce the stromal collagenThe ECM laid down by CAPaSC is considered to be o ...

    STTR Phase II 2018 Department of Health and Human Services
  4. Media-based youth e-cig prevention toolkit for community-based organizations

    SBC: KDH Research And Communication, Inc.            Topic: NIDA

    KDH Research and CommunicationKDHRCsubmits this Fast Track SBIR proposal to develop and evaluate AVOIDAnti Vaping Online Information Disseminationa media based online toolkit to support community based organizationsCBOprevention programming against youth e cigarettee ciguseYouth e cig usealso known asvapingis a rapidly growing public health threatwith use among high school students tripling fromto ...

    SBIR Phase II 2018 Department of Health and Human Services
  5. Three-dimensional testicular cell co-culture model for reproductive toxicity screening

    SBC: REPROTOX BIOTECH L.L.C.            Topic: NIEHS

    Summary Reproductive and developmental disorders caused by drugs or environmental chemicals are a prominent health issue worldwideCurrent toxicity testing methods set by regulatory agencies predominately rely on animal testingThe cost and time associated with animal testing for risk assessment seriously limit efforts for extensive toxicity screeningThese data gaps necessitate the implementation of ...

    SBIR Phase II 2018 Department of Health and Human Services
  6. Hemonauts- Interactive Digital Media for Increased STEM Learning Among Chronically Ill Children and Their Support Networks

    SBC: Thrust Interactive, Inc.            Topic: 500

    Abstract This proposal seeks to create the Hemonauts suite of interactive digital mediaIDMto serve chronically illfrequently hospitalized students in grades five through eight and their support networks toiIncrease STEM content knowledge through gameplayiiIncrease knowledge of and intent to persist in STEM careersandiiiIncrease disease literacy to improve patient self advocacytreatment compliancea ...

    SBIR Phase II 2018 Department of Health and Human Services
  7. Advanced Prodrug Treatment for CML

    SBC: INHIBIKASE THERAPEUTICS            Topic: 399

    Inhibikase Therapeutics is a clinical stagebio pharmaceutical company that has developed a novel prodrug formulation for the popular anticancer agent GleevecGleevectreatment is commonly accompanied by significantburdensome gastrointestinal side effectsfatigue and myalgias that erode therapy success due to poor patient complianceInhibikaseandapos s prodrug of GleevecIkTProProcompletely blunts these ...

    SBIR Phase II 2018 Department of Health and Human Services
  8. Clinical Testing of the First Suspension BHK-M Cell Platform Derived Biotherapeutic


    PROJECT SUMMARY ABSTRACT The long term objective of current project is to commercialize a novel coagulation factor product manufactured using a novel production cell linedesignated ET i BHK M with a primary indication of treatment of anti drug antibodies that develop following the treatment of congenital hemophilia A with factor VIIIfVIIIreplacement productsExpression Therapeutics has developed mu ...

    SBIR Phase II 2018 Department of Health and Human Services
  9. Tools for drug efficacy studies in perfused tissue models

    SBC: Lena Biosciences, Inc.            Topic: 100

    Organ on a chip tools that recapitulate human biologyphysiology and pathology are urgently needed in applied science research and drug testing to expedite discoveries while reducing research costs and animal sacrificeUnfortunatelymost products incorporating circulation mimicking perfusion are too complicated for researchers to useincompatible with many protocols and readsand low throughputOur goal ...

    SBIR Phase II 2018 Department of Health and Human Services
  10. Self-advocacy training for students with cochlear implants entering higher education

    SBC: KDH Research And Communication, Inc.            Topic: NIDCD

    KDH Research andampCommunicationKDHRCsubmits this Phase II Small Business Innovation ResearchSBIRapplication to expand and fully evaluate Cochlear Implant UniversityCIUCIU is an onlineselfadvocacy skills building resource for high school and college students with cochlear implantsCIsagedand their parentsCIU seeks to develop high school and college studentsself advocacy knowledge and skills to supp ...

    SBIR Phase II 2018 Department of Health and Human Services

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