Award Data

Abstract This project aims to develop and commercialize the Volumetric Calcium Imaging 2-Photon Activity Microscope, vCAm™, a revolutionary new 2-photon microscope based on a technological breakthrough called Light Beads Microscopy (LBM) that was recently developed by Dr. Alipasha Vaziri and co-workers (Lab. Neurotechnol. Biophys., Rockefeller Univ., New York, NY). The game-changing innovation i ...

Perinatal brain injury resulting in mental retardation and cerebral palsy is the most severe disability in children and affects 40-148 in preterm and 1–2/1000 in full term infants. This places a huge burden on society, emphasizing the critical need for improved prevention/treatment strategies to decrease perinatal brain injury. Hypothermia (HT) is the only FDA approved therapy to attenuate brain ...

Abstract This Phase II project describes the commercial development of HyperAxon™, highly innovative software for performing automated segmentation, tracing, reconstruction and quantitative analysis of all axonal fibers (with and without signs of acute axonal injury) visible in two- and three-dimensional (2D and 3D) microscopy images of central nervous system (CNS) areas, even those with extreme ...

Abstract This project aims to develop the 2P-ActivityScope™, a revolutionary new microscope based on a technological breakthrough called second-generation Scanned Line Angular Projection (SLAP2) two photon laser scanning microscopy that was recently developed by Dr. Kaspar Podgorski (Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA). The game-changing innovation in the 2P-Ac ...

PROJECT SUMMARY / ABSTRACT This proposal will result in a major new clinical decision support software system, Acuity, which will assist Behavior Analysts (BAs) and Behavior Technicians (BTs) in the delivery of Applied Behavior Analysis (ABA), which is the leading treatment for autism. This is a proposal to develop software and perform a functional impact and implementation outcomes study on 34 BA ...

Abstract This project describes the development of NeuroExM™, a highly innovative system for performing comprehensive spatial distribution analysis of populations of messenger RNAs (mRNAs) and proteins in tissue processed for expansion microscopy (ExM)). The groundbreaking technological advantage of ExM, which was recently developed by Dr. Edward S. Boyden (Dept. Biol. Engin., Media Lab and Dept ...

Experiad will develop a new type of parent engagement platform, called Goalspace, which will facilitate parent- assisted Applied Behavior Analysis (ABA). Goalspace has the potential to have a major impact on autism treatment worldwide by increasing the amount of parent engagement in ABA therapy. Demand for ABA services far exceeds capacity. Parent-assisted ABA is a key evidence-based component of ...

ABSTRACT The American Heart Association estimates that, in 2022, about 720,000 Americans will have a first coronary event and 335,000 will have a recurrent event, of which, approximately 87% are ischemic (thrombotic). Anti- thrombotic therapy reduces the risk of recurrent ischemic events at the cost of a greater incidence of bleeding complications. Patients at low thrombotic/ischemic risk should b ...

Pipeline and Hazardous Materials Safety Administration (PHMSA) is actively involved in the safe transportation of energy and hazardous material that are vital to daily lives. This also includes underground natural gas storage (UNGS) maintenance and safe operation which are critical to nation's energy infrastructure. Enhancing leak detection and identifying smart ways to prevent potential well blow ...

Abstract/Project SummaryAlong with the many benefits of a global economy hides the ever-present risk for the world wide spread of infectious disease. While significant outbreaks of the flu in the recent past involving millions of individuals could be contained, the emergence and rapid spread of the SARS-CoV-2 virus revealed how vulnerable and unprepared the world population was to combat a previou ...