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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. System for Volumetric 2-photon Imaging of Neuroactivity Using Light Beads Microscopy

    SBC: MICROBRIGHTFIELD, LLC            Topic: 101

    Abstract This project aims to develop and commercialize the Volumetric Calcium Imaging 2-Photon Activity Microscope, vCAm™, a revolutionary new 2-photon microscope based on a technological breakthrough called Light Beads Microscopy (LBM) that was recently developed by Dr. Alipasha Vaziri and co-workers (Lab. Neurotechnol. Biophys., Rockefeller Univ., New York, NY). The game-changing innovation i ...

    SBIR Phase II 2023 Department of Health and Human ServicesNational Institutes of Health
  2. Development of a regional anesthesia guidance system to increase patient access to opioid-sparing analgesia for hip fracture pain

    SBC: RIVANNA MEDICAL, INC.            Topic: NIAMS

    PROJECT SUMMARY/ABSTRACT For the rt330,000 Americans that are hospitalized for hip fractures yearly, rapid treatment of pain and surgical intervention is critical to recover mobility and reduce the risk of death. Parenteral opioids are the standard of care to manage acute hip fracture pain but increase the risk of adverse events and outcomes, including delirium and recurrent opioid use. Ultrasound ...

    SBIR Phase II 2023 Department of Health and Human ServicesNational Institutes of Health
  3. Inter-alpha Inhibitors in Hypoxic-Ischemic Brain Injury

    SBC: PROTHERA BIOLOGICS, INC.            Topic: 105

    Perinatal brain injury resulting in mental retardation and cerebral palsy is the most severe disability in children and affects 40-148 in preterm and 1–2/1000 in full term infants. This places a huge burden on society, emphasizing the critical need for improved prevention/treatment strategies to decrease perinatal brain injury. Hypothermia (HT) is the only FDA approved therapy to attenuate brain ...

    SBIR Phase II 2023 Department of Health and Human ServicesNational Institutes of Health
  4. Rapid Development of a Lead Aromatic Aldehyde Derivative with both Oxygen Dependent and Novel, Oxygen Independent Anti-Sickling Effects: Building on a Paradigm Shift in Sickle Cell Disease Therapy

    SBC: IllExcor Therapeutics LLC            Topic: NHLBI

    Sickle Cell Disease (SCD) affects ~100,000 individuals in the US and millions more worldwide. The disease causes a range of adverse pathophysiological effects resulting in painful crises, organ failure, and eventually, premature death. Our scientists spearheaded the development of a novel class of oral anti-sickling drugs based on natural aromatic aldehydes, like vanillin from vanilla extract. Thi ...

    SBIR Phase II 2023 Department of Health and Human ServicesNational Institutes of Health
  5. Novel therapeutic approach for severe ARDS with a potent pharmacologic allosteric hemoglobin modifier

    SBC: IllExcor Therapeutics LLC            Topic: NHLBI

    Acute respiratory distress syndrome (ARDS) is a life-threatening condition featuring acute onset of non- cardiogenic respiratory failure and hypoxemia. Consequently, patients with ARDS have severe hypoxemia due to a significant impairment of gas exchange, and the goal of supportive therapy is to prevent critical tissue hypoxia, which can cause acute cardiac arrest and death or have long-term neuro ...

    SBIR Phase II 2023 Department of Health and Human ServicesNational Institutes of Health
  6. Next generation axonal quantification and classification using AI

    SBC: MICROBRIGHTFIELD, LLC            Topic: 101

    Abstract This Phase II project describes the commercial development of HyperAxon™, highly innovative software for performing automated segmentation, tracing, reconstruction and quantitative analysis of all axonal fibers (with and without signs of acute axonal injury) visible in two- and three-dimensional (2D and 3D) microscopy images of central nervous system (CNS) areas, even those with extreme ...

    SBIR Phase II 2023 Department of Health and Human ServicesNational Institutes of Health
  7. Reducing Hypertension among African American Men: A Mobile Stress Management Intervention to Address Health Disparities

    SBC: ISA ASSOCIATES INC            Topic: NIMHD

    PROJECT SUMMARY/ABSTRACTAfrican American men have the highest rate of hypertension (HTN) in the United States. Once diagnosed, they are also less likely to achieve blood pressure (BP) control. This health disparity is critical, as elevated BP is the primary modifiable risk factor for cardiovascular disease. One reason for this HTN disparity: stress. African Americans report more stress than their ...

    SBIR Phase II 2023 Department of Health and Human ServicesNational Institutes of Health
  8. Microscope system for large scale optical imaging of neuronal activity using kilohertz frame rates

    SBC: MICROBRIGHTFIELD, LLC            Topic: 105

    Abstract This project aims to develop the 2P-ActivityScope™, a revolutionary new microscope based on a technological breakthrough called second-generation Scanned Line Angular Projection (SLAP2) two photon laser scanning microscopy that was recently developed by Dr. Kaspar Podgorski (Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA). The game-changing innovation in the 2P-Ac ...

    SBIR Phase II 2023 Department of Health and Human ServicesNational Institutes of Health
  9. High Performance Nanocomposite Kraft Papers to Improve Insulation and Lifetime of Large Power Transformers

    SBC: C-CRETE TECHNOLOGIES LLC            Topic: C

    Transformers are critical for the power grid distributions via stepping up down the voltage. The key cause of failure in majority of transformers is the insulation problem related to the kraft paper. The objective of this project is to integrate a collection of advanced surface chemistry, kraft paper fabrication, and rapid property screening, followed by standard testings and pilot demonstration t ...

    SBIR Phase I 2023 Department of EnergyARPA-E
  10. High Performance Nanocomposite Kraft Papers to Improve Insulation and Lifetime of Large Power Transformers

    SBC: C-CRETE TECHNOLOGIES LLC            Topic: C

    Transformers are critical for the power grid distributions via stepping up down the voltage. The key cause of failure in majority of transformers is the insulation problem related to the kraft paper. The objective of this project is to integrate a collection of advanced surface chemistry, kraft paper fabrication, and rapid property screening, followed by standard testings and pilot demonstration t ...

    SBIR Phase II 2023 Department of EnergyARPA-E
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