Award Data

DISORDERS OF CUTANEOUS HYPERPIGMENTATION ARE A COMMON PROBLEM CAUSING SUBSTANTIAL MORBIDITY WHICH RANGES FROM COSMETIC EMBARASSMENT TO SOCIAL DISGRACE, DEPENDING ON THE EXTENT OF PIGMENTATION AND ON RACIAL EXTRACTION. AT LEAST 5% OF PATIENT VISITS TO DERMATOLOGISTS ARE FOR THESE DISORDERS FOR WHICH THERE IS NO ADEQUATE THERAPY. DISORDERSWITH INCREASED EPIDERMAL PIGMENTATION, SUCH AS LENTIGINES (LI ...

RECENT PROTON MICROPROBE STUDIES ON TRACE ELEMENTS IN SEVERAL HUMAN DISORDERS HAVE SHOWN THE SUPERIORITY OF THE PROTON AS COMPARED TO THE ELECTRON MICROPROBE. THIS HAS BEEN DRAMATICALLY DEMONSTRATED IN STUDIES OF ALUMINUM IN ALZHEIMER'S DISEASE. THE REASON FOR THE PROTON BEAM'S SUPERIORITY IS THE SUPPRESSION OF BACKGROUND X-RAY GENERATION WHEN LOOKING AT X-RAYS CHARACTERISTIC OF THE TRACE ELEMENTS ...

A SERIES OF COMPOUNDS THAT ARE EITHER HOMODIMERS OR HETERODIMERS OF SPECIFIC DIDEOXYNUCLEOSIDES HAVE BEEN SYNTHESIZED. IN VARIOUS ASSAYS, THE PHOSPHATE-LINKED DIMERSOF SUCH ANTIVIRAL MONOMERIC DIDEOXYNUCLEOSIDES POSSESS GREATER ACTIVITY THAN THE COMBINED ACTIVITY OF THE DIDEOXYNUCLEOSIDES ADMINISTERED ALONE. PRELIMINARY PHARMACOKINETIC DATA OBTAINED FOR ONE OF THE AGENTS AFTER INTRAVENOUS ADMINIST ...

UNTIL 10 YEARS AGO, LYME DISEASE (LD) WAS MOSTLY UNKNOWN IN USA, ALTHOUGH SOME OF ITS CLINICAL MANIFESTATIONS HAVE BEEN REPORTED IN EUROPE SINCE 1909. THE FIRST FEW LD CASES (ACTURALLY MORE THAN 50 IN THE SAME AREA) IN USA WERE DISCOVERED IN 1975; AND ITS ETIOLOGY (BORRELIA BURGDORFERI) AND MODE OF INFECTION (TICK BITES) WERE DETERMINED A FEW YEARS LATER. WITH THIS INFORMATION, DEFINED CLINICAL FE ...

DOWEL BARS HAVE TRADITIONALLY BEEN USED AS AN IMPORTANT LOADTRANSFER MECHANISM ON OUR FEDERAL HIGHWAYS. A SIGNIFICANT PROBLEM OCCURRS WITH THE USE OF THESE BARS DUE TO RUST AND RESULTANT SPALLING AND CRACKING CONCRETE. COMPOSITE REINFORCING BARS (CRB) HAVE BECOME WIDELY USED FOR CRACK CONTROL IN MANY REINFORCED CONCRETE STRUCTURES EXPOSED TO AGGRESSIVE ENVIRONMENTS. A LIMITED AMOUNT OF DATA IS AVA ...

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STRIATAL TRANSPLANTATION OF NEUROTRANSMITTER CELLS, IMMUNOISOLATED WITHIN A PERMSELECTIVE POLYMER MEMBRANE CAPSULE, REPRESENTS A NOVEL APPROACH TO THE TREATMENT OF PARKINSON'S DISEASE. THE TECHNIQUE HAS HAD PROMISING RESULTS IN SEVERAL RODENT MODELS, AND PRIMATE STUDIES ARE UNDERWAY. THE OVERALL OBJECTIVE OF THIS RESEARCH IS TO COMPLETE THE DEVELOPMENTS NECESSARY FOR WIDESPREAD MEDICAL ACCEPTANCE ...

THE OBJECT OF THIS PROJECT IS TO DEVELOP AND IMPLEMENT THE CONCEPT OF A COMPUTER WORKSTATION FOR NEUROLOGY. THE SYSTEM WILL HAVE ALL THE PRESENT FUNCTIONALITY OF THE EEG MACHINE, BUT WILL BE ENHANCED WITH CHARACTERISTICS INTRINSICTO THE COMPUTER. THE POSSIBILITIES OF THE INSTRUMENT FOR THE CLINICAL ENVIRONMENT WILL BE STRESSED: MAKE PRECISE MEASUREMENTS IN THE EEG (MICROVOLT ACCURACY AND MILLISECO ...

DEPRESSION IS A HETEROGENOUS DISEASE, COVERING A RANGE OF SEVERITY, QUALITIES, AND CAUSES THAT AFFECTS AN IMPORTANT PORTION OF POPULATION. NONE OF THE AVAILABLE TREATMENT MODALITIES OF DEPRESSION, INCLUDING ELECTROCONVULSIVE THERAPY AND PHARMACOTHERAPY MAINLY BY TRICYCLICS AND MONOAMINE OXIDASE INHIBITORS, ARE TOTALLY SATISFACTORY AND NEW DRUGS ARE NEEDED. THE MAO INHIBITORS HAVE BEEN UNDERRATED M ...

INTRAOCULAR PRESSURE (IOP) IS NOT ADEQUATELY CONTROLLED BY SINGLE DRUG THERAPY IN MORE THAN 50 PERCENT OF GLAUCOMA PATIENTS. THE DEVELOPMENT OF ADDITIONAL DRUGS TO TREAT GLAUCOMA EITHER ALONE OR IN COMBINATION WITH ADRENERGIC BETA-ANTAGONISTS IS THEREFORE APPROPRIATE. THIS PROJECT SEEKS TO DEVELOP PRODRUGS OF PILOCARPINE. THESE PRODRUGS ARE EXPECTED TO REDUCE THE ELEVATED IOP THAT IS ASSOCIATED WI ...