Award Data

THE OBJECTIVE OF THIS SBIR PROJECT IS TO DEVELOP A NEW, SOLID STATE IMMUNOSENSOR WITH CAPABILITIES FOR USE IN HOMES,FARMS, FACTORIES AND OFFICES FOR ON-SITE QUANTITATIVE DETERMINATION OF HORMONES, DRUGS AND TOXINS IN BIOLOGICAL FLUIDS SUCH AS PLASMA, SALIVA, AND URINE. THE PRINCIPLE OF DETECTION WILL BE BASED ON AN ENZYME-AMPLIFIED, IMMUNOELECTROCHEMICAL SOLID STATE DETECTOR THAT CAN BE COUPLED TO ...

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STRIATAL TRANSPLANTATION OF NEUROTRANSMITTER CELLS, IMMUNOISOLATED WITHIN A PERMSELECTIVE POLYMER MEMBRANE CAPSULE, REPRESENTS A NOVEL APPROACH TO THE TREATMENT OF PARKINSON'S DISEASE. THE TECHNIQUE HAS HAD PROMISING RESULTS IN SEVERAL RODENT MODELS, AND PRIMATE STUDIES ARE UNDERWAY. THE OVERALL OBJECTIVE OF THIS RESEARCH IS TO COMPLETE THE DEVELOPMENTS NECESSARY FOR WIDESPREAD MEDICAL ACCEPTANCE ...

THE LONG-TERM OBJECTIVE OF THIS RESEARCH IS THE DEVELOPMENT AND INTRODUCTION TO MEDICAL PRACTICE OF AN EFFECTIVE BIOCOMPATIBLE IMPLANTABLE HYBRID ARTIFICIAL ENDOCRINE PANCREAS THAT IS CAPABLE OF SIGNIFICANT IMPROVEMENT IN THE THERAPY OF INSULIN-DEPENDENT DIABETES. THE SPECIFIC AIM OF THIS PROJECT IS TO EXTEND AND MODIFY A PROCESS FOR CELLULAR ENCAPSULATION TO THE ISLETS OF LANGERHANS, USING A CO-E ...

OCCUPANT INJURY CAN BE SIGNIFICANTLY REDUCED BY THE INCORPORATION OF PADDING OF HARD SURFACES IN VEHICLE INTERIORS. SEVERAL INTERIOR HARD SURFACES SUCH AS ROOF HEADER, A-PILLAR, AND B-PILLAR ARE DIFFICULT TO PAD DUE TO LIMITED SPACE. WAT IS NEEDED IS AN INFLATABLE PLASTIC BI-LAYER THAT COULD BE ATTACHED TO HARD SURFACES AND GIVE ACCEPTABLE WEAR AND APPEARANCE WHEN UNINFLATED, YET BE INFLATABLE DUR ...

IT IS PLANNED TO MEASURE PERIODONTAL DISEASE ACTIVITY VIA QUANTIFICATION OF CERTAIN BY-PRODUCTS OF BACTERIAL METABOLISM IN THE INFECTED POCKET. IT IS KNOWN THAT AN ANEROBIC ENVIRONMENT PROVIDES A NECESSARY CONDITION FOR AN ACTIVE DISEASE, BUT THIS CONDITION MAY NOT BE SUFFICIENT. OTHER RELEVANT CHEMICAL CONDITIONS MAY INVOLVE THE PH AND CONCENTRATIONS OF H2S AND HS . HENCE, AN "ACTIVITYINDEX" BASE ...

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WITH THE INCREASING LONGEVITY OF THE U.S. POPULATION, THE PROBLEMS OF DIAGNOSING AND TREATING GERIATRIC DISORDERS ARE BECOMING A MAJOR PUBLIC HEALTH CONCERN. TO SUPPORT THE CLINICIAN IN THE TASK OF GERIATRIC DIAGNOSIS, A PROTOTYPE EXPERT SYSTEM, INTERLOCUTOR, HAS BEEN DEVELOPED. THIS PROJECT WILL CONVERT THIS PROTOTYPE SYSTEM INTO AN APPLICATION PROGRAM. A CONTROLLED TEST WILL BE PERFORMED WITH A ...