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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Development of PEGylated MTI for the treatment of relapsed Myeloma

    SBC: MODULATION THERAPEUTICS, INC.            Topic: 102

    ABSTRACT Modulation Therapeutics is developing a first in class cyclic peptide coined MTI for the treatment of multiple myeloma The company currently has a license for the parent molecule which has been awarded a patent covering the intellectual property for both composition of matter and use in cancer in the US and Europe Modulation Therapeutics is now poised to further advance this class ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  2. Developing an integrated sorting and single cell analysis tool for the analysis of rare T Cells subsets in Autoimmunity

    SBC: IsoPlexis            Topic: R

    Autoimmune disease AD affects up to million Americans which costs approximately $ billion on health care annually and accounts for one of the leading causes of death in women T cells and cytokine function play an important role in autoimmune diseases such as Type Diabetes Multiple Sclerosis Rheumatoid Arthritis RA and Systemic Lupus Erythematosus SLE The most successful auto i ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  3. ATCOM SHARP Box for Real-Time Turbulence Mitigation

    SBC: EM PHOTONICS INC            Topic: NASAA402

    When imaging over long distances, atmospheric turbulence between the camera and subject degrades the collected data limiting the effective resolution, regardless of the quality of the optic and sensor used. This reduction in image quality can have serious impacts on the ability to carry out missions by reducing situational awareness and preventing target identification. EM Photonics has been worki ...

    SBIR Phase II 2017 Department of DefenseSpecial Operations Command
  4. Assembled Porous Silica Membranes for Biomolecule SPE

    SBC: ADVANCED MATERIALS TECHNOLOGY, INC.            Topic: 400

    Abstract Life sciences research and other critical bioanalytical applications would strongly benefit from faster and higher efficiency sample preparation processes Sample preparation before high resolution analytical methods such as HPLC or LC MS can require effort and cost nearly equivalent to the actual sample analysis and data reduction Often sample preparation for proteomic glycoproteom ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  5. Novel Nanofiltration Membranes for Isolation of Pharmaceutical Compounds II

    SBC: COMPACT MEMBRANE SYSTEMS, INC.            Topic: 300

    DESCRIPTION provided by applicant In the manufacture of pharmaceutical compounds organic syntheses are often carried out in organic solvents These solvents must then be separated from high value intermediates and active pharmaceutical ingredients APIs in order to produce the final product medications Many intermediate compounds and APIs are thermally labile and thermal separation processes ...

    SBIR Phase II 2016 Department of Health and Human ServicesNational Institutes of Health
  6. Glycosaminoglycans to Treat and Prevent Radiation Induced Oral Mucositis

    SBC: GLYCOMIRA, LLC            Topic: NIDCR

    ABSTRACT Oral mucositis is a devastatingly painful inflammatory disease that frequently develops during cancer therapy and affects half a million people in the US The accompanying pain is so severe that patients often require narcotic pain medicines The clinical manifestations are ulcers in the mouth and gastrointestinal tract which are exacerbated by opportunistic infections Many patients al ...

    SBIR Phase II 2016 Department of Health and Human ServicesNational Institutes of Health
  7. Production of therapeutic human polyclonal antibodies against influenza viruses

    SBC: SAB Biotherapeutics, Inc.            Topic: R

    DESCRIPTION provided by applicant A research plan is proposed to produce potent human polyclonal antibodies against influenza viruses by immunizing genetically modified bovines with seasonal influenza vaccine in combination with a strong adjuvant and immune stimulator Previous studies have demonstrated that genetically engineered bovines are capable of producing large amounts of human polyclo ...

    SBIR Phase II 2016 Department of Health and Human ServicesNational Institutes of Health
  8. Development of a Non adjuvanted VLP Vaccine against Stealth H N Influenza

    SBC: EPIVAX, INC.            Topic: NIAID

    DESCRIPTION provided by applicant The avian origin H N influenza virus that emerged in humans in China in presents a unique challenge to vaccine development because it is poorly immunogenic Neutralizing antibodies are not detected in acute phase infection Anti H antibody responses are significantly delayed and exhibit low avidity in comparison with antibodies generated following seas ...

    SBIR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  9. A Phase a clinical trial of ALK in geographic atrophy

    SBC: ALKEUS PHARMACEUTICALS, INC.            Topic: NEI

    DESCRIPTION provided by applicant The long term goal of this work is to develop an oral drug for the prevention of age related macular degeneration AMD AMD is the leading cause of blindness in the United States with million Americans diagnosed or at risk of irreversibly losing vision and over million people who already have debilitating vision loss Currently there is no FDA approved ...

    SBIR Phase II 2016 Department of Health and Human ServicesNational Institutes of Health
  10. A Potent and Safe Antimicrobial Prosthetic Liner to Control Odor & Reduce Infection for Lower Limb Amputees

    SBC: Antimicrobial Materials, Inc.            Topic: NICHD

    DESCRIPTION provided by applicant Silicone roll on prosthetic liners are widely used by lower limb amputees Most patients however complain of skin related issues due to the warm moist environment The long term goal of this SBIR project is to develop and commercialize a vastly improved silicone prosthetic liner with antimicrobial properties so as to improve hygiene and greatly reduce risk of ...

    SBIR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health

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