Award Data

SRD will develop a miniaturized atmospheric gas sensor array and design a gas analyzer (sensor analyzer module, SAM) capable of accurately detecting and autonomously monitoring critical atmospheric gases in enclosed spaces. In this Phase I effort, SRD will use its current, existing technology (miniaturized sensor platform, proprietary SMO sensor coatings and advanced signal processing algorithms) ...

Positioning and navigation have become a mainstay of everyday life in the U.S.; applications of interest include navigation of vehicles of all kinds, infrastructure mapping, and safety of life systems. Many of these recent applications have become possible through the GPS. With the recognized vulnerabilities of GPS, it is evident that equivalent backup systems must be developed. One possible so ...

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DESCRIPTION (provided by applicant): BCR Diagnostics, Inc. (BCR) has recently developed and patented a technology platform for engineering fluorogenic functionality into living Bacillus spores. Fluorogenic spores (F-spores) produced at BCR appear to be phy siologically identical to normal spores except for performing as self reporters of initial germination events. Considering the unique features ...

BIODE, INC., WILL UTILIZE THE RESULTS OF ITS PHASE I RESEARCH TO DEVELOP A TOTALLY NEW SOLID-STATE SENSOR TECHNOLOGY FOR BIOLOGICAL MEASUREMENTS. THIS TECHNOLOGY IS BASED UPON THE MERGING OF TWO OTHER RELATIVELY NEW TECHNOLOGIES: NUCLEIC ACID PROBES (NUCLEIC ACID HYBRIDIZATION) WITH ACOUSTIC PLATE MODE (APM) MICROSENSORS. BY COMBINING THE SENSITIVITY OF APM SENSORS WITH THE SPECIFICITY OF NUCLEIC ...

BIODE, INC., WILL UTILIZE THE RESULTS OF ITS PHASE I RESEARCH TO DEVELOP A TOTALLY NEW SOLID-STATE BIOSENSOR TECHNOLOGY FOR BIOLOGICAL MEASUREMENTS. THIS TECHNOLOGY IS BASED UPON THE MERGING OF TWO OTHER RELATIVELY NEW TECHNOLOGIES, MONOCLONAL ANTIBODIES (HYBRIDOMA TECHNOLOGY) WITH ACOUSTIC WAVE MICROSENSORS. BY COMBINING THE SENSITIVITY OF ACOUSTIC WAVE SENSORS WITH THE SPECIFICITY OFANTIBODIES, ...

ONE OF THE MAJOR CHALLENGES IN THE PRODUCTION OF THERAPEUTICALLY USEFUL PROTEINS, INCLUDING PRODUCTS OF RECOMBINANT DNA TECHNOLOGY, IS RAPID AND COST-EFFECTIVE PURIFICATION OF THE PROTEINS. HIGH-PERFORMANCE IMMUNOAFFINITY CHROMATOGRAPHY IS A POWERFUL NEW TECHNIQUE FOR PROTEIN PURIFICATION AT PRODUCTION SCALE. THE USE OF THIS TECHNIQUE HAS BEEN HAMPERED BY THE EXPENSE AND DIFFICULTY OF CUSTOM COUPL ...

DESCRIPTION (provided by applicant): This Phase II project will complete development of the SMART (Self-Monitoring and Review Tool) Log program for symptom management and health promotion in fibromyalgia (FM), and evaluate its efficacy in a large web-based trial that will closely emulate its planned application in Phase III. The SMART Log program is an interactive web-based self-monitoring and fe ...

THE PROJECT WILL DEMONSTRATE THAT, THROUGH VIDEOTAPE TRAINING AND SUPPORT PRINT MATERIALS, CHILD WELFARE PRACTITIONERS CAN USE THE ABC MODEL TO ASSIST FAMILIES IN MANAGING THE BEHAVIOR OF CHALLENGING CHILDREN AND YOUTH IN FOSTER, ADOPTIVE, AND BIRTH HOMES. THE TRAINING PACKAGE WILL INCLUDE A VIDEOTAPE, SUPPORTING PRINT MATERIALS, AND A SELF-TEST. THE VIDEOTAPE WILL HAVE TWO PARTS. PART I WILL USE ...

THE LONG TERM OBJECTIVE OF THIS RESEARCH IS THE DEVELOPMENT AND INTRODUCTION INTO CLINICAL PRACTICE OF AN EFFECTIVE, AND BIOCOMPATIBLE IMPLANTABLE-HYBRID- ARTIFICIAL-PANCREAS WHICH IS CAPABLE OF SIGNIFICANT IMPROVEMENT IN THERAPY OF INSULIN DEPENDENT DIABETES. THE SPECIFIC AIM OF THIS PROJECT IS TO INVESTIGATE METHODS OF IMPROVING THE VIABILITY AND FUNCTION OF MACRO-ENCAPSULATED ISLETS. DEVELOPMEN ...