Award Data

In this innovative Phase I effort, nSI will construct and demonstrate an empirically driven directed evolution model that rapidly selects for BBB-crossing NPs in vitro, as a proof of concept. Leveraging cutting-edge NP formulation advances, we will (1) synthesize a library of DNA-barcoded NPs, (2) administer the library in multiplex to in vitro BBB models, (3) use the BBB infilitration data collec ...

The overall objective of the Phase II effort is to further investigate the generations of RF emissions from the detonation of high explosives and how those signatures maybe used to further understand the complex interactions within an event as well as the physics responsible for their generation. To accomplish this objective, IS4S will conduct an optimized series of experiments based on the lesson ...

The potential of explosive energetics has long elicited the need for understanding, control, and optimization. Scientific theory, development, and experimental investigations collaborate to create applications for offensive and defensive strategies. Visual evidence of ionization, subsequent recombination, and shockwave interaction indicate that dynamic electrical potential distributions are intrin ...

The objectives of this Phase II study are to develop a complete end-to-end capability for the operational hazard assessment modeling within limnological systems for all of CONUS and to develop preliminary techniques to determine limnological water quality parameters of OCONUS systems, allowing for the eventual hazard assessment modeling in denied or restricted regions. Achieving these objectives w ...

Improvised Explosive Devices (IEDs) are a dangerous and effective weapon system that today’s military warfighters and innocent civilians regularly experience. IEDs are created with randomly assembled materials and their payloads may include projectiles, biological toxins, and other dangerous items that can cause injury or death to personnel and equipment. Detection and neutralization of these we ...

Terrorist use of radioactive nuclear materials via nuclear and/or radiological dispersion devices (dirty bombs) is a serious threat. Therefore, it is crucial to detect proliferation of nuclear material. Critical challenges include: (a) high sensitivity detection of signature emissions from radioactive isotopes, and (b) cost-effectiveness for deployment of sensor networks across large storage facil ...

The objective of this study is to develop methods to adequately characterize the chemical and physical environments of lakes and reservoirs for the CONUS operational implementation within SHARC. Over the course of this project we will explore the novel and innovative integration of deep machine learning, data analytics, computational fluid mechanics and in-situ/overhead empirical data. Specificall ...

Cost-effective application of advanced commercial electronics technologies in DoD space systems requires early development of radiation-hardened-by-design (RHBD) techniques, and use of simulations is critical to the efficiency of this process. CFDRC has developed an integrated, mixed-mode simulation approach allowing their NanoTCAD device physics simulator to interface with commercial circuit simu ...

Some of our nations adversaries possess advanced technologies and equipment necessary for the processing and development of Weapons of Mass Destruction (WMD). There is a growing risk that these capabilities and technologies will be used against the United States or our allies. For this reason, an opportunity exists to develop offensive solutions that will enable warfighters to combat WMD at the so ...

Terrorist use of radioactive nuclear materials via nuclear and/or radiological dispersion devices (dirty bombs) is a serious threat. Therefore, it is critical to detect the proliferation of nuclear material. Critical challenges facing this objective include: (a) high sensitivity detection of signature emissions (e.g., gamma rays) from common radioactive isotopes behind shielding, and (b) cost-effe ...