Award Data

Software development faces many challenges as high-performance computing (HPC) moves towards exascale: scalability, programmability, performance portability, resilience, and energy efficiency. To tackle these challenges, fundamental shifts in the basic execution models and programming models employed by HPC software are required. In particular, commonly used linear algebra libraries performance s ...

Researchers at JBEI have developed a pretreatment technology using ionic liquids that efficiently extracts sugars from a combination of mixed feed stocks. Any ionic liquid used for biomass pretreatment or cellulose hydrolysis by thermostable cellulose may be used. Until now, no known technology could efficiently pretreat and liberate sugars from mixed feedstock streams. The JBEI technolo ...

Oxygen enriched air (OEA) can be a valuable tool to enhance combustion processes, reduce CO2 emissions per unit of heat generated and also concentrate CO2 to enhance subsequent CO2 concentration ahead of CO2 sequestering. OEA reduces the presence of parasitic nitrogen and therefore flame temperature and associated heat transfer is higher with OEA. Studies show that using 40-50% OEA, which is the p ...

Solid state lighting has not yet taken off in commercial buildings due to its high relative installed cost. On a normalized basis, solid state lighting replacement lamps are on the order of two times more expensive than equivalent compact fluorescent lamps (CFLs), and five times more expensive than an equivalent downlight fixture. An additional barrier relates to the performance and cost of the dr ...

Industrial hydrogen production relies primarily on natural gas and hydrocarbon feedstocks to drive the various reaction chemistries that lead to hydrogen generation. Carbon dioxide, the ultimate co- product when such feedstocks and processes are employed, necessarily becomes a major contaminant of the generated hydrogen. Thus, carbon dioxide isolation and removal is an important process step in ...

The problem being addressed in this proposal is the existing extensive use of energy hungry hot water heaters in both residential and commercial building in the United States. In addition, any attempts to date to create a low energy hybrid hot water heater (HWH) have resulted in hot water heaters so loud that they cannot feasibly be used in residential applications. This project entails the develo ...

DESCRIPTION (provided by applicant): Calista Therapeutics has invented Calcaftor, a first-in-class peptide drug that can treat all Cystic Fibrosis (CF) patients. Calcaftor is validated in the gold standard pre-clinical model of CF using F508 -CFTR lung tissue harvested from CF transplant patients. Results from this model demonstrated a gt25 hour duration of action that enables once daily inhaled n ...

DESCRIPTION (provided by applicant): Trace elements are well known to have critical roles in a wide variety of diseases, including cancer and neurodegenerative diseases such as Alzheimer's and Wilson's diseases. Due to their biological importance, there have been numerous studies performed with spectroscopy techniques such as laser ablation inductively coupled mass spectrometry (LA-ICP-M ...

DESCRIPTION (provided by applicant): Neonatal hypoxia-ischemia (HI) remains a major cause of acute perinatal brain injury, leading ultimately to neurologic dysfunction manifesting as cerebral palsy, mental retardation, and epilepsy. Cerebral oxygen deprivation and/or reduced blood flow due to umbilical cord occlusion, prolonged labor, and/or intracranial hemorrhage produce an inflammatory respons ...

The overarching objective of this project is to develop an innovative technological tool that will facilitate the implementation of an evidence-based substance abuse prevention program and related health behavior risk programs among military personnel. PUBLIC HEALTH RELEVANCE