Award Data

Project Summary: The objective of this proposed research program is to develop a platform for planning and guidance during Radio Frequency Ablation (RFA). RFA is a thermally mediated ablation technique, where an applicator carrying one electrode is inserted into tumors percutaneously (or via laparoscopy, or open surgical approaches). Radio Frequency (RF) energy is applied, denaturating and coagula ...

Results of Phase II research indicate that formal validation of the EpiAirwayin vitro human bronchial tissue model for predicting toxicity of inhaled chemicals is an attainable goalThe proposed Phase IIB cooperative agreement project is intended to realize this goal by conducting formal ring trial validation studies that will be submitted to regulatory agencies and the Organization for Economic Co ...

ABSTRACTThe overall goal of this Phase II project is to validate novel leishmanial protein biomarkers for development of a non invasive urine based assay to diagnose active visceral leishmaniasisVLand to monitor the therapeutic efficacy of this serious diseaseVL is endemic incountriesaffectspeople a year and kills more thanof them children under ageVLalso known as kala azaris caused by parasites o ...

Project Summary First episode psychosis is a serious mental health condition that affects youth and young adultsoften between the ages ofandThe illness is marked by hallucinationsdelusionswithdrawalpoor organization skillsand diminished cognitive and social functioningRecent research has demonstrated that programs designed to treat people experiencing early psychosis can reduce hospitalizationdecr ...

Chronic musculoskeletal pain creates a significant public health burden, and Veterans are disproportionately affected. The frequency and extent of co-occurrence of pain and PTSD, pain and Traumatic Brain Injury (TBI), all three conditions (Post-deployment Multi-symptom Disorder (PMD), and other multi-symptom syndromes can complicate and reduce the effectiveness of pain treatment. Furthermore, the ...

TheWHO guidelines recommend anti retroviral therapyARTfor all HIV infected peopleand massive efforts to expand ART access will result in andgtM adults and andgtM children on ART byat a cost of almost US$BConsequentlythe number of patients prescribed alternativeprotease inhibitorPIbased ART following failure of first line regimens will also increaseStudies of patients on PI based ART in resource li ...

Radikal TherapeuticsRTXis developing a pioneering therapy to restore immunotolerance and arrest progressive depigmentation in vitiligoAt our partnering institutionLoyola University Chicagoa variant to inducible Heat Shock Proteinwas developed with remarkable potential for the prevention and treatment of autoimmune vitiligoCarrying only a single amino acid modification to the proteinthis variant HS ...

Non alcoholic steatohepatitisNASHis characterized by fatty changes in the liver with inflammation and hepatocellular injury that in advanced stages leads to fibrosiscirrhosis and high mortality ratesNASH is frequently associated with other common metabolic abnormalitiessuch as insulin resistance and visceral obesityLiver transplantation is currently the only effective therapeutic approach for seve ...

PROJECT SUMMARY ABSTRACT The skeleton is the third most common site of metastatic cancerand nearly half of all cancers metastasize to boneAs a result of new and aggressive treatments cancer patients are living longerbut at sites of skeletal metastasis fractures occur inof affected bones after minimal traumaThis significantly impacts patient functioning and quality of lifeWhile much has been learne ...

Abstract The Eutropics PraediCare Dxis an emerging clinical diagnostic assay that will be used to predict patient response to specific chemotherapiesUnlike existing assaysPraediCare Dxpredicts response to specific chemotherapies by direct evaluation of cancer cells potential to enter into an apoptotic state following exposure to therapyPraediCare Dxhas the potential to provide actionable data for ...