Award Data

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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until September, 2020.

  1. Minimal piggyBac vectors for chromatin integration

    SBC: EXSCIEN CORPORATION            Topic: NIGMS

    In this grant, we describe novel transposon piggyBac vectors engineered to deliver transgenes as efficiently as currently available piggyBac systems, but with significantly less helper DNA co-delivered into the host genome. To generate these plasmids, we first identified an important and previously unreported aspect of transposon biology, that the full-length terminal domains required for successf ...

    STTR Phase I 2014 Department of Health and Human Services
  2. Enhancing mtDNA Repair During Stroke Reperfusion to Reduce Brain Damage

    SBC: EXSCIEN CORPORATION            Topic: NINDS

    DESCRIPTION (provided by applicant): Attempts to develop drug treatments for acute stroke have not fulfilled expectations. Perhaps best illustrating this unsatisfactory situation is the hisory of therapeutic strategies directed at the inhibition of reactive oxygen species (ROS). While decades of laboratory and clinical studies make it clear that ROS are pathogenically important across the entire s ...

    STTR Phase I 2014 Department of Health and Human Services
  3. New Functionally-Graded Biohybrid Vascular Graft

    SBC: Vivo Biosciences Inc            Topic: NCATS

    DESCRIPTION (provided by applicant): In this Phase I STTR proposal, our RandD goal is the development and evaluation of a novel functionally-graded biohybrid vascular graft for small diameter (lt6 mm) coronary bypass applications. Tissue engineered vascular constructs developed to date have mostly utilized synthetic and animal- derived biomaterials and require pre-seeding of host cells before impl ...

    STTR Phase I 2014 Department of Health and Human Services
  4. Macromolecule Crystallization Screening Results Analysis

    SBC: IXPRESSGENES, INC.            Topic: 100

    DESCRIPTION provided by applicant Crystallization followed by subsequent structure determination is a major step in understanding the structure function relationship of macromolecules Understanding macromolecule structure has become a key part in the development of new pharmaceuticals and is a major area of NIH research Crystallization however is also the rate limiting step despite techno ...

    STTR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  5. Development of a Novel Membrane Protein Solubilization/Stabilization Screen

    SBC: SOLUBLE THERAPEUTICS, INC            Topic: 100

    DESCRIPTION provided by applicant The increasing output of new integral membrane protein IMP structures is partially due to the availability of an increasing number of chemical variables such as detergents detergent like molecules lipids and solubilizing stabilizing additives It is clear that specific combinations and concentrations of these different variables are often necessary to impr ...

    STTR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  6. Impact of Hypersonic Flight Environment on Electro-Optic/Infrared (EO/IR) Sensors

    SBC: Analysis and Applications Associates, Inc.            Topic: AF15AT40

    ABSTRACT: Analysis and Applications and Associates, Inc. (AAA) proposes to develop software that evaluates effects of the hypersonic flow environment on electro-optic/infrared optical systems and vehicles for specific hypersonic flight profiles. We propose a high fidelity definition of the near-field flow, using the latest CFD and turbulence modeling technologies, to determine the environment from ...

    STTR Phase I 2015 Department of DefenseAir Force
  7. Blended Reality Solution for Live, Virtual, and Constructive Field Training

    SBC: Mike Sutton Consulting, Inc.            Topic: AF17AT011

    The proposed Small Business Technology Transfer (STTR) Phase I project will determine the technical feasibility and cost-effectiveness of utilizing emerging blended-reality technologies that enable interoperability with LVC simulations to create more effective and comprehensive Battlefield Airmen training environments. The proposed training technologies will be integrated across multiple platforms ...

    STTR Phase I 2017 Department of DefenseAir Force
  8. High speed, multispectral, linear polarization display

    SBC: Polaris Sensor Technologies, Inc.            Topic: AF17AT021

    Several birds and insects use sky features such as sun, moon or star positions, sky polarization and even forest canopy structures to navigate and maintain heading in day or night conditions. To better understand this ability in insects, a sky projector is needed to allow researchers to project realistic sky images to the insect so that insect response can be studied. Polaris proposes to partner ...

    STTR Phase I 2017 Department of DefenseAir Force
  9. Fast Optical Limiters (OL) with Enhanced Dynamic Range

    SBC: AEGIS TECHNOLOGIES GROUP, INC., THE            Topic: AF17AT029

    The proliferation of commercial, visible and infrared wavelength laser systems is increasingly becoming an existential threat to our warfighters, which drives the need for further EO/IR sensor and eye protection development. Current fielded sensor protection is limited to fixed wavelength filters. Broadband filters designed to circumvent multi-wavelength laser threats are plagued by low transmitta ...

    STTR Phase I 2017 Department of DefenseAir Force
  10. Bayesian Inference of Spacecraft Geometry and Pose

    SBC: VISION SYSTEMS INC.            Topic: AF17AT007

    Space platforms are complex dynamical systems and there are many reasons to model them from ground telescope imagery as well as from space-based sensor platforms. One key motivation is to determine the operational state and configuration of the vehicle. Key questions such as did the solar panels fail to deploy, did the object begin to tumble unexpectedly may be addressed by a sufficiently detaile ...

    STTR Phase I 2017 Department of DefenseAir Force
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