Award Data

ABSTRACT Stroke is the fifth leading cause of death and the leading cause of disability in the United StatesThere remains a critical need for innovative therapeutic approaches that can successfully prevent or reverse brain injury following strokeDysfunction of the mitochondrial biochemistry following ischemic stroke and reperfusion injury contributes to significant neuronal cell losshoweverthe dev ...

Major depressive disorder is a debilitating mood disorder that affects ~7% of US adults in their lifetime, costing the U.S. economy more than $200 billion a year. Drugs that increase monoaminergic signaling are the mainstay of depression therapy, but have a delayed onset of action and are only effective in about 50% of affected patients. Aberrant brain-derived neurotrophic factor (BDNF) signaling ...

Project SummaryNovel High Resolution Scintillation X ray Detectors for Digital Dentistry The transition from traditional film to digital X ray detectors has resulted in significant improvements across many areas for dental X ray imaging ranging from decreased wait timesimproved logistics and even lower radiation dose ratesOne significant drawback remains with digital X ray imaging howeverwhich is ...

Durable and robust large-area ultrathin CNT sheets can be produced from pristine CNT sheets following proprietary CNT purification and densification processes. The resulting CNT sheets are free-standing, flexible, durable, robust, ultrathin (< 5 µm) and lightweight (~6 g per m2). They withstand corrosion and heat and are superior at shielding EMI (effectiveness >= 55 dB in the X band).

Managing multi-level risks ranging from the fiscal/personnel resources to fluctuating material/production costs have always been challenges due to the integrated nature of Air Force (AF) with governmental and industrial partners. Establishing a quantitative framework that provides basis for making informed decisions on these pressing issues can greatly impact how Air Force strategically allocate v ...

Petal is a novel bio-solar proposal to generate power using plant photosynthetic proteins combined to nanotubes bonded to a conductive substrate. The use of this architecture should allow for high efficiencies in the capture and harvest of photons and the generation of solar power in a very flexible format. This format will allow for scaling from micro to industrial scales.

Increases in space traffic have caused an ever-growing need to recognize, track, and inspect both known and unknown satellites in-situ. Imagery from ground observation platforms provide a convenient and versatile data source for such characterization but is often limited in both quantity and quality. Rapid and automated 3D reconstruction of satellite models from limited 2D imagery would significan ...

Based on the results of Phase I, we aim to develop a prototype of the high speed dynamic IRSP instrument. This prototype will incorporate the next generation 1Kx1K IRLED array that is compatible with the highly successful and user-tested NSLEDS IRSP. If Phase II of the proposed project is successful, the result will be an upgrade of NSLEDS IRSP system to higher performance and operability. The rea ...

Abstract Primary central nervous system lymphoma PCNSL is an aggressive brain tumor with a dire unmet therapeutic need It has an overall incidence of per person years and is regarded as an orphan disease with potential for fast track approval Our group made a discovery via gene expression analysis that osteopontin OPN is the most upregulated gene in PCNSL compared to its non CNS ...

Summary Approximatelymillion women in the United States are at high risk for developing breast cancerbased on inheritance of a germline mutation in a gene in the double strand breakDSBrepair and cyclin checkpoint pathwaysMany are unaware of their genetic predispositionsbecause their family history is uninformative or unknownGenetic testing is important for identifying mutations in these genesbut i ...