Award Data

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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until September, 2020.

  1. Receptors, Ligands, and Catalysts on Demand using Expanded Genetic Alphabets

    SBC: FIREBIRD BIOMOLECULAR SCIENCES LLC            Topic: 100

    ABSTRACTTechnology to deliveron demandmolecules that bind targets or catalyze reactions of choice has been a goal of chemistry foryearsEven todaytheory is inadequate to support de novo design of receptors having useful affinity or catalysts having useful turnoverThusmany have sought to create those catalysts on a DNA or RNAcollectivelyxNAusing the Darwinism to these biomolecules to evolveunder lab ...

    STTR Phase II 2017 Department of Health and Human Services
  2. Developing a novel therapy for diabetic retinopathy

    SBC: Everglades Biopharma, LLC            Topic: W

    Project Summary Diabetic retinopathy DR is a leading cause of vision loss affecting about million people worldwide A major breakthrough in DR therapy is the recent approval of vascular endothelial growth factor VEGF inhibitors However anti VEGF therapy has limited efficacy with a number of side effects The critical barrier is how to identify other angiogenic targets for alternative or ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  3. Probabilistic Modeling for Software Guided Radiotherapy Patient Plan QA

    SBC: SUN NUCLEAR CORP.            Topic: 103

    Errors in the planning and delivery of radiation therapy can result in inferior outcomes for patients The magnitude of this problem is now well appreciated from cooperative group trials and other sources At present however there are few concrete tools to reduce the chance of plan errors passing undetected Current practice uses a variety of error mitigation means such as human inspection of th ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  4. Identification of Small Molecule Amyloid Beta Peptide Reducing Agent

    SBC: Smart Biomolecules, Inc.            Topic: NIA

    Alzheimer s disease AD is a multifactorial heterogeneous and enormously complex disorder characterized by progressive intellectual deterioration Although remarkable advances have been made in unraveling the biological basis of the disease in the last two decades that immense knowledge has not been translated in to successful therapy With the failure of secretase inhibitors at the clinical tr ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  5. Electrochemical Micro-Capacitors Utilizing Carbon Nanostructures

    SBC: MAINSTREAM ENGINEERING CORPORATION            Topic: DMEA13B001

    The rapid advancement of microelectronics requires equivalently sized energy storage devices to provide energy for microelectromechanical system (MEMS) devices and other technologies. By using a novel approach to fabricate carbon nanotubes (CNTs), our electrodes have a high surface area with an aerial tube density up to 1,000 times greater than typical carpet-grown CNTs. By combining these electro ...

    STTR Phase II 2017 Department of DefenseAir Force
  6. A Randomized Blinded Placebo Controlled Clinical Trial to Evaluate Longeveron Mesenchymal Stem Cell LMSC Therapy for Treating The Metabolic Syndrome

    SBC: Longeveron LLC            Topic: NIA

    The metabolic syndrome MetS is a cluster of factors that increases the risks for cardiovascular disease type diabetes mellitus and mortality and currently affects andgt of US adults MetS is associated with endothelial dysfunction decreased circulating endothelial progenitor cells EPCs and a pro inflammatory state We have made the exciting discovery that therapy with allogeneic me ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  7. Multi-Scale Simulation Framework for Heterogeneous Energetic Materials

    SBC: Streamline Numerics, Inc.            Topic: AF15AT28

    This Phase II STTR proposal will develop a computational tool for state-of-the-art computational modeling of multi-scale thermo-mechanics of heterogeneous energetic materials. The proposal will bring together researchers with long-standing expertise in flow software and physical modeling of high-speed reactive multi-material flows to work on further developing a cutting-edge computing tool called ...

    STTR Phase II 2017 Department of DefenseAir Force
  8. High-Frequency Calibration System for Sensors Used in High-Speed Airflow Measurements

    SBC: Interdisciplinary Consulting Corporation            Topic: AF17AT003

    The Interdisciplinary Consulting Corporation (IC2) in partnership with the University of Florida, proposes to develop and standardize a novel, high-frequency dynamic pressure sensor calibration method and system for sensors used in the measurement of high speed flows. The proposed innovation is a novel calibration method combined with modified and repurposed measurement hardware to enable calibra ...

    STTR Phase I 2017 Department of DefenseAir Force
  9. Learner Engagement and Motivation to Learn Assessment and Monitoring System

    SBC: Design Interactive, Inc            Topic: AF17AT009

    Training can now delivered on a large scale through platforms, but must be engaging to be effectively utilized. Key to providing training that makes a difference in the field is an understanding of how to induce high levels or engagement during learning, and the ability to objectively assess engagement in real-time so that interventions can be tailored during training to optimize engagement and m ...

    STTR Phase I 2017 Department of DefenseAir Force
  10. Development lightmap rendering technology to advance infrared simulation capabilities for training applications

    SBC: Cornerstone Software Solutions, Inc            Topic: AF17AT012

    Recent technology advances have enabled the simulation community to achieve greater realism in virtual training environments. As new methods for synthetic image generation are developed, the lack of readily available supporting data to populate these specialized techniques limits their implementation. Currently the capability is not available to efficiently generate enhanced temporal energy maps ...

    STTR Phase I 2017 Department of DefenseAir Force
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