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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. Development of the first thermolytic to suppress shivering and seizure

    SBC: BE COOL PHARMACEUTICS LLC            Topic: NHLBI

    Summary The temperature management market is expected to reach $billion byyet no pharmaceutical has yet been developed specifically for this marketAadenosineA ARagonists are well known to attenuate seizure and protect the brain from injurybut development of these drugs has been limited by side effects including hypothermiabradycardia and hypotensionInspired by our discoveries thatN cyclohexyl aden ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  2. Noninvasive Contrast Enhanced Early Detection of Melanoma Liver Metastasis

    SBC: INLIGHTA BIOSCIENCES L.L.C.            Topic: 102

    Abstract The liver is the most common organ for metastasis of various cancersincluding pancreaticovariancolorectalgastric cancers and melanomaUveal melanoma metastasizes inof patients and upon metastasis targets the liver inof these casesThe most common primary malignant liver cancer worldwide is hepatocellular carcinomaHCCThe use of blind liver biopsy as a diagnostic tool for liver cancer has man ...

    STTR Phase II 2017 Department of Health and Human ServicesNational Institutes of Health
  3. Engineering probiotics to biosynthesize natural substances for microbiome brain research

    SBC: HGG Research LLC            Topic: R

    PROJECT SUMMARY To advance microbiome brain studies the general goals of this collaborative proposal are to provide services to research community by engineering probiotics e g E coli Nissle EcN Bifidobacteria longum Lactobacillus plantarum to biosynthesize various naturally occurring chemicals as prebiotic probiotic conjugates which will be marketed as important laboratory agents ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  4. A MODULAR, EXPANDABLE, LOW COST MBE SYSTEM FOR A NEW GENERATION OF EPITAXY

    SBC: Innovative Advanced Materials, Inc.            Topic: AF16AT25

    Innovative Advanced Materials (IAM), Inc., founded by MBE expert Dr. W. Alan Doolittle, has developed a new generation of MBE tools with revolutionary capability and remarkably lower cost than legacy tools and proposes to construct a prototype tool to demonstrate its power. The prototype tool will be delivered to AFRL for use in the growth of Gallium Oxide shattering current technical roadblocks c ...

    STTR Phase II 2017 Department of DefenseAir Force
  5. Preventing Vascular Complications in Type Diabetes Muscle Metabolic Monitoring

    SBC: Infrared Rx, Inc.            Topic: NIDDK

    Project Summary Abstract While much has been accomplished in managing hyperglycemia morbidity and mortality in patients with type diabetes T D often results from cardiovascular complications Evidence suggests peripheral artery disease and skeletal muscle mitochondrial dysfunction One reason is the lack of reliable tools to characterize skeletal muscle microcirculation and mitochondrial capa ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  6. Selenium-derivatized New Reagents for Nucleic Acid X-ray Crystallography

    SBC: SENA RESEARCH, INC.            Topic: NIEHS

    DESCRIPTION provided by applicant There are growing demands for D structure determination of nucleic acids and their protein complexes for understanding disease molecule level mechanisms and discovering innovative drugs X ray crystallography is one of the most direct and powerful tools for structure determination of these macromolecules and complexes However the crystallization and phase d ...

    STTR Phase II 2015 Department of Health and Human ServicesNational Institutes of Health
  7. RealConsent: A web-based program to reduce college women's risk of sexual violence by targeting alcohol use, communication and consent, and building supportive networks.

    SBC: BEHAVIORAL SCIENCE TECHNOLOGIES LLC            Topic: 400

    Sexual violenceSVexperienced by women on college campuses is a serious public health problem that has garnered a national responseCampus climate surveys show that approximately one in five college women experience sexual violenceFederal regulations now mandate implementation of educational prevention programs for new students of institutions of higher educationIHEsBest practices for sexual violenc ...

    STTR Phase II 2017 Department of Health and Human ServicesNational Institutes of Health
  8. Small molecule therapy for metastatic prostate cancer

    SBC: MetCure Therapeutics LLC            Topic: 102

    Enzalutamide resistance is a major obstacle in the treatment of metastatic castration resistant prostate cancer mCRPC Recently we developed a small molecule lead compound GH and demonstrated its potent activity against bone metastatic prostate cancer cells In this Phase I STTR application we hypothesize that GH is a novel lead compound with nanomolar potency against enzalutamide resist ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  9. Nutritional Therapy in Elderly with Heart Failure

    SBC: Essential Blends, LLC            Topic: NIA

    Project Summary Abstract We have developed a nutritional formulation of amino acids called UpBeat that is designed to promote physical function and quality of life in older individuals with heart failureReduced exercise capacity is a prominent clinical feature of heart failureThis leads to progressive muscle weakness and a vicious cycle of sedentary behaviorweight gainand subsequent development of ...

    STTR Phase II 2017 Department of Health and Human ServicesNational Institutes of Health
  10. Anti CCL mAb to treat castration resistant prostate cancer

    SBC: JYANT Technologies, Inc.            Topic: 102

    Metastatic castration resistant prostate cancer CRPC PCa accounts for of PCa deaths and is associated with skeletal metastases CRPC affects patients differently making this disease difficult for physicians to provide standardized treatments with similar outcomes Docetaxel can prolong the overall survival in patients with metastatic CRPC but current therapies do not provide a cure Doce ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
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