Award Data

ABSTRACT Pediatric injury is the leading cause of child mortality and acquired disability in the United Statesaffectingmillion children annuallyAmong school age children alonemore thanmillion are treated in Emergency Department or admitted to the hospital annually for injuryincurring billions in medical and work loss costs each yearAfter hospital dischargemany injured children experience pain that ...

The objective of this proposal is to continue the development and prove the manufacturability of fast axis collimating lenses for quantum cascade lasers (QCL) which emit in the midwave-infrared (MWIR) range. These lenses must withstand the stress of both continuous wave (CW) and pulsed laser emission. These high laser powers may cause ablation of lens material reducing effectiveness of the optic a ...

ABSTRACT Nearlypercent of death and diseaseworldwideis linked to environmental factorsWHOthereforeit is critical that the general public has a basic understanding of how the environment affects their health and how they might protect themselves against environmental exposuresUnfortunatelyenvironmental health is typically covered minimallyif at allin secondary school classroomsMartinaand there are ...

Summary The goal of this study is to discover novelmechanism based pharmacological intervention for autisma devastating neurodevelopmental disorder with no treatment currentlyGenetic sequencing has revealed extensive overlap in risk genes for autism and for cancermany of which are chromatin remodeling factors important for transcriptional regulationsuggesting the possibility of repurposing the ant ...

Project SummaryA Novel Polymeric Valve for Transcatheter Aortic Valve Replacement Minimally invasive transcatheter aortic valve replacementTAVRhas emerged as an effective therapy for the unmet clinical need of inoperable patients with severe aortic stenosisASRecent longitudinal follow up studies of TAVR patients however indicate that this procedure and associated technology may result in serious a ...

ABSTRACT Colorectal cancerCRCis the third leading cause of cancer related deaths in the U SBased on numerous epidemiological studies and recent prospective clinical trialsthe use of daily aspirin is associated with a significant reduction in CRC incidencedeaths and metastatic spreadHoweverthe chronic use of this drug is limited due to the side effects of gastrointestinal bleeding ulceration in sus ...

Embedded systems are critical to national security and personal safety. However, the level of security provided by most embedded systems is low. In this project, we are building WARP, a tool for Weaving Application-specific Runtime Policies into embedded systems binaries. WARP enables end users to formulate and enforce custom run-time policies that protect the software from external attacks and in ...

The Kerberos team is developing a man-portable, commercial-off-the-shelf (COTS)-based, open-architecture prototype system for executing reactive and targeted electronic attack (EA) operations against modern communication signals.This solution, called Electromagnetic Monitor and Broadcast System (EMBS) will offer an extensible platform designed to defeat current waveforms with open interfaces and m ...

PROJECT DESCRIPTIONThis STTR Phase I proposal is intended to demonstrate the feasibility of developing tanshinone small molecule analogTSAas an effective and safe small molecule therapy for patients with sepsis and septic shockIn the USmore than one million people develop sepsis every yearYetno effective anti sepsis treatment exists other than antibiotics and supportive careWe have discovered that ...

The main objective for Knowledge Based Systems, Inc. (KBSI) for this project is to develop the Training Environment for Design of Resilient Systems (TENSILITY) method and supporting framework to enable Platform Information Technology (PIT) and PIT systems designers, systems designers, systems integrators, systems test and evaluation (T&E) engineers, and hardware, firmware and software developers t ...