Award Data

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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until September, 2020.

  1. Recombinant Silk Elastin-like Protein Polymers for the Embolization of Cerebral Aneurysms

    SBC: TheraTarget, Inc.            Topic: 106

    NARRATIVE This STTR Phase I proposal details the rationale and the research plan for the development of a novel liquid embolizing agent composed of the genetically engineered protein polymerSELPsilk elastinlike proteinKto embolize cerebral aneurysmsThe SELP embolic would reduce the risk of aneurysm rupture while minimizing the risk of recanalization after treatment and providing a platform for del ...

    STTR Phase I 2017 Department of Health and Human Services
  2. Multiscale Simulation Framework for Modeling of Structural Reactive Materials

    SBC: WASATCH MOLECULAR, INC.            Topic: AF16AT23

    We propose to develop a set of multiscale modeling tools for structural reactive materials (SRMs) that explicitly treat microscale, mesoscale and macroscale coupling of mechanical response, thermal properties and chemical reactions. At the macroscale, a combined material point method (MPM, solid)/Eulerian (ICE, fluid) methodology, MPM-ICE, will be employed to investigate the behavior of select int ...

    STTR Phase II 2017 Department of DefenseAir Force
  3. Visually driven disease variant analysis empowering real time clinical research

    SBC: Frameshift Labs, Inc.            Topic: NHGRI

    Project Summary Identifying disease causing genetic variants is a complex process that requires experts from multiple fields including bioinformatics IT systems administration and disease pathology to work closely together The size of sequencing data files also adds the requirement for large computational resources As a result performing genomic analyses is an ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  4. Bayesian Inference of Spacecraft Geometry and Pose

    SBC: VISION SYSTEMS INC.            Topic: AF17AT007

    Space platforms are complex dynamical systems and there are many reasons to model them from ground telescope imagery as well as from space-based sensor platforms. One key motivation is to determine the operational state and configuration of the vehicle. Key questions such as did the solar panels fail to deploy, did the object begin to tumble unexpectedly may be addressed by a sufficiently detaile ...

    STTR Phase I 2017 Department of DefenseAir Force
  5. An MPM-based Multiscale Framework for Simulations of Mesoscale Heterogeneous PBXs

    SBC: WASATCH MOLECULAR, INC.            Topic: AF15AT28

    ABSTRACT: We will develop a multiscale molecular dynamics/material point method (MD/MPM) methodology for determining the response of PBXs to a wide range of loading conditions as a function of mesoscale structure with emphasis on accurate representation of interfacial physics. The initial material of choice will be HMX + DOA plasticized HTPB binder. Velocity-dependent grain-grain and viscoelastic ...

    STTR Phase I 2015 Department of DefenseAir Force
  6. Rapid Monitoring and Assessment of Tubercuolosis Treatment at the Point of Care Using Breath

    SBC: NanoSynth Materials and Sensors Inc.            Topic: NHLBI

    DESCRIPTION provided by applicant Problem and Significance According to the CDC global statistics nearly of the world is infected with Tuberculosis TB In million f peopled infected lived in what is considered a high burden country Countries such as India Peru China sub Saharan Africa and others have significant regions endemic for TB particularly among the lower income ...

    STTR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  7. Backbone Degradable Polymer-drug Conjugates for the Treatment of Ovarian Cancer

    SBC: TheraTarget, Inc.            Topic: NCI

    DESCRIPTION provided by applicant The purpose of this Phase II STTR project is to develop a polymeric system for the combination delivery of two antineoplastic agents gemcitabine and paclitaxel Based on the successful results of the STTR Phase I award this Phase II proposal details the rationale and research plan for the synthesis and evaluation of in vivo efficacy of two novel macromolecula ...

    STTR Phase II 2014 Department of Health and Human ServicesNational Institutes of Health
  8. Biomimetic Material Solutions for the Stabilization of Labile Reagents

    SBC: Technology Holding, LLC            Topic: AF15AT29

    ABSTRACT: Elimination of the cold chain is of vital importance for the ability to treat injured warfighters in the field and behind enemy lines. The application of an already FDA approved reagent for the stabilization of labile reagents will allow for minimal development time delaying the fielding of a new technology to fill this role. Collagen has been used extensively since the 1980s as an appro ...

    STTR Phase I 2015 Department of DefenseAir Force
  9. Hepatitis C Virus RNA-Targeted Therapeutics

    SBC: VIOGEN BIOSCIENCES, LLC            Topic: NIAID

    DESCRIPTION (provided by applicant): Hepatitis C virus (HCV) infection is a significant human health issue, accounting for 50% of liver transplants in the US, with approximately 170 million persons infected worldwide. The current standard of care therapy of PEGylated-interferon and ribavirin is effective in only about 50% of patients, with severe side effects and contraindications limiting patient ...

    STTR Phase I 2014 Department of Health and Human Services
  10. Selective activation of the vagus nerve as an improved therapy for heart failure

    SBC: BLACKROCK MICROSYSTEMS            Topic: NHLBI

    DESCRIPTION (provided by applicant): The goal of the proposed project is to alleviate the enormous public health burden of heart failure. Heart failure leads to significant morbidity and mortality, affects almost five million Americans, and results in morethan 35 billion dollars in annual healthcare costs. Current pharmacological and surgical treatments are only moderately effective and can have s ...

    STTR Phase I 2014 Department of Health and Human Services
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