Award Data

Abstract Pancreatic cancers are devastating diseases with five year survival rate less than Currently there is no effective treatment for advanced disease One major barrier to efficacy of anti tumor therapeutics is the dense desmoplastic stromal response Evidence suggests that cancer associated pancreatic stellate cells CAPaSC produce the stromal collagen The ECM laid down by CAPaSC is c ...

PROJECT SUMMARY We will develop and commercialize to the research community a new class of glycan specific binding reagents that incorporate the recognition function of variable lymphocyte receptors VLRs the antigen receptors of the adaptive immune system of jawless vertebrates lamprey and hagfish Such reagents are essential to detecting localizing quantifying and establishing biological ...

Sexual violenceSVexperienced by women on college campuses is a serious public health problem that has garnered a national responseCampus climate surveys show that approximately one in five college women experience sexual violenceFederal regulations now mandate implementation of educational prevention programs for new students of institutions of higher educationIHEsBest practices for sexual violenc ...

Enzalutamide resistance is a major obstacle in the treatment of metastatic castration resistant prostate cancer mCRPC Recently we developed a small molecule lead compound GH and demonstrated its potent activity against bone metastatic prostate cancer cells In this Phase I STTR application we hypothesize that GH is a novel lead compound with nanomolar potency against enzalutamide resist ...

PROJECT SUMMARY ABSTRACT Over a quarter of primary care patients in the United States can be classified as unhealthy drinkers because their alcohol use conveys a high risk of health and social consequences Unfortunately unhealthy drinking is under recognized in spite of the existence of valid screening tools Even when unhealthy drinking is recognized barriers such as provider discomfort shor ...

Optical limiters (OL) protect sensitive optical and electronic devices from laser-induced damage. The existing passive OL utilize nonlinear optical materials transmitting low-intensity light, while blocking laser radiation with intensity exceeding certain limiting threshold (LT). The common problem with the existing OL is that, at any particular frequency range, the choice of suitable nonlinear ...

Space platforms are complex dynamical systems and there are many reasons to model them from ground telescope imagery as well as from space-based sensor platforms. One key motivation is to determine the operational state and configuration of the vehicle. Key questions such as did the solar panels fail to deploy, did the object begin to tumble unexpectedly may be addressed by a sufficiently detaile ...

Innovative Advanced Materials (IAM), Inc., founded by Dr. W. Alan Doolittle, proposes to develop a new generation of bulk synthesis tools operating at significantly higher pressure than current prototype systems which already demonstrate tantalizing material quality and high growth rates with proven alloy and dopant control capability to produce AlGaN substrates with remarkably low cost and high q ...

Innovative Advanced Materials (IAM), Inc., founded by MBE expert Dr. W. Alan Doolittle, has developed a new generation of MBE tools with revolutionary capability and remarkably lower cost than legacy tools and proposes to construct a prototype tool to demonstrate its power. The prototype tool will be delivered to AFRL for use in the growth of Gallium Oxide shattering current technical roadblocks c ...

Abstract The liver is the most common organ for metastasis of various cancersincluding pancreaticovariancolorectalgastric cancers and melanomaUveal melanoma metastasizes inof patients and upon metastasis targets the liver inof these casesThe most common primary malignant liver cancer worldwide is hepatocellular carcinomaHCCThe use of blind liver biopsy as a diagnostic tool for liver cancer has man ...