Award Data

This revised proposal is in response to PAR"BRAIN InitiativeDevelopmentOptimizationand Validation of Novel Tools and Technologies for Neuroscience Research"Our overall goal is to enable positron emission tomographyPETas a practical and effective quantitative tool in understanding brain function and healthIn vivo functional imaging of molecular tracers will play a key role in unraveling the physiol ...

Project Summary Abstract Mitochondrial dysfunction causes mitochondrial diseases and is tightly linked to aging and neurodegenerative disorders such as Parkinsonandapos s and Alzheimerandapos s Recent discoveries support that mitochondrial dysfunction can be overcome to treat age related decline Cytegenandapos s hypothesis is that exercise induces the secretion of blood borne proteins that act ...

Plasmodium falciparum is the most virulent form of malaria causing million deaths per year Success with patient treatment and a malaria eradication campaign depends significantly on our ability to detect new infections as early as possible in the field rural areas including asymptomatic cases preferably using a small amount of blood e g from a finger prick and to clearly discrim ...

PROJECT SUMMARY There is an increasing public concern about monitoring water quality in the entire drinking water supply system especially at the point of use spurred by recent water catastrophes such as the one in Flint Michigan that has caused severe health issues for thousands of children due to the unsafe level of lead in contaminated drinking water Current quantitative detection methods ...

DESCRIPTION provided by applicant The goal of this project is to develop functional magnetic resonance imaging fMRI tools to assist the diagnosis and treatment of human patients with a brain tumor or other operable pathology The specific focus of this proposal is to produce a practical clinic ready suite of MR imaging methods analyses and display tools to solve the number one impediment to ...

DESCRIPTION provided by applicant Burkholderia pseudomallei is a Gram negative bacterium that is the causative agent of melioidosis The bacterium causes significant morbidity and mortality in tropical regions and endemic areas are expanding Melioidosis is difficult to trea and diagnose due to the fact that B pseudomallei is resistant to common antibiotics and symptoms are non specific Morta ...

Respiratory infections with influenza viruses cause severe morbidity and mortality in humans and animals worldwideImportantlyin humansthe majority of morbidity and mortality following flu infection is seen in older individualsrtyears oldYetclear understanding of how aging impacts on innate immune responsesand how to improve vaccine design in this age group is lackingRestimulating preexisting memor ...

Project Summary Stem cell research has shown great potential to help treat or even cure a wide array of health conditions including cardiovascular and neurological disease cancer and diabetes This field is now beginning to move rapidly from the re search stage to clinical translation and commercial applications However it has been widely recognized that stem cell scientists have difficulty ...

PROJECT SUMMARY In the US roughly in children experience a mental health problem severe enough to warrant intervention of them receive treatment in the education sector However schools are often unable to deliver high quality evidence based treatments The goal of this project is to improve the quality of school based mental health SMH services by leveraging health information te ...

DESCRIPTIONprovided by applicantCardiovascular diseases and Asthma affects betweenandmillion people in the United States includingmillion childrenduring the pastyearsits incidence worldwide has doubledAsthma is responsible formillion person days of restricted activity anddeaths per yearamounting to $billion in direct heath related coststhere is uncertainty about the specific factors that are contr ...