Award Data

Project Summary Abstract Mitochondrial dysfunction causes mitochondrial diseases and is tightly linked to aging and neurodegenerative disorders such as Parkinsonandapos s and Alzheimerandapos s Recent discoveries support that mitochondrial dysfunction can be overcome to treat age related decline Cytegenandapos s hypothesis is that exercise induces the secretion of blood borne proteins that act ...

Plasmodium falciparum is the most virulent form of malaria causing million deaths per year Success with patient treatment and a malaria eradication campaign depends significantly on our ability to detect new infections as early as possible in the field rural areas including asymptomatic cases preferably using a small amount of blood e g from a finger prick and to clearly discrim ...

PROJECT SUMMARY There is an increasing public concern about monitoring water quality in the entire drinking water supply system especially at the point of use spurred by recent water catastrophes such as the one in Flint Michigan that has caused severe health issues for thousands of children due to the unsafe level of lead in contaminated drinking water Current quantitative detection methods ...

DESCRIPTION provided by applicant The goal of this project is to develop functional magnetic resonance imaging fMRI tools to assist the diagnosis and treatment of human patients with a brain tumor or other operable pathology The specific focus of this proposal is to produce a practical clinic ready suite of MR imaging methods analyses and display tools to solve the number one impediment to ...

Respiratory infections with influenza viruses cause severe morbidity and mortality in humans and animals worldwideImportantlyin humansthe majority of morbidity and mortality following flu infection is seen in older individualsrtyears oldYetclear understanding of how aging impacts on innate immune responsesand how to improve vaccine design in this age group is lackingRestimulating preexisting memor ...

Project Summary Stem cell research has shown great potential to help treat or even cure a wide array of health conditions including cardiovascular and neurological disease cancer and diabetes This field is now beginning to move rapidly from the re search stage to clinical translation and commercial applications However it has been widely recognized that stem cell scientists have difficulty ...

Space platforms are complex dynamical systems and there are many reasons to model them from ground telescope imagery as well as from space-based sensor platforms. One key motivation is to determine the operational state and configuration of the vehicle. Key questions such as did the solar panels fail to deploy, did the object begin to tumble unexpectedly may be addressed by a sufficiently detaile ...

DESCRIPTION provided by applicant The human transcriptome is significantly more complex than its cognate genome due to the hundreds of thousands of possible isoforms allele specific expression issues variable RNA editing changes and differential expression patterns spanning cell types developmental stages and physiological stresses Next generation sequencing NGS platforms are fundame ...

DESCRIPTION provided by applicant Neurodegenerative diseases that affect motor neurons such as PD ALS and HD represent an enormous unmet medical need that is growing with the aging population Existing treatments have little or no effect on the course of disease and patients have to cope with the loss of brain and body function for the rest of their lives Defects in the transport of organell ...

DESCRIPTION provided by applicant The goal of iFIT Prosthetics LLC r and its founder was to create and commercialize a modular immediate fit fully adjustable transtibial prosthesis system suitable for mass production using high strength polymer materials that are injection molded at a fraction of the cost of conventionally made prostheses This goal was achieved and now the aims of this P ...