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Project Summary Abstract Mitochondrial dysfunction causes mitochondrial diseases and is tightly linked to aging and neurodegenerative disorders such as Parkinsonandapos s and Alzheimerandapos s Recent discoveries support that mitochondrial dysfunction can be overcome to treat age related decline Cytegenandapos s hypothesis is that exercise induces the secretion of blood borne proteins that act ...

Title Development of a Photoacoustic Quantitative Ultrasound PAQUS device for clinical use Abstract The objective of this program is to develop a highly innovative bone assessment device by combining our recently invented photoacoustic physio chemical analysis PAPCA technique with more established quantitative ultrasound QUA techniques After a clinic ready Photoacoustic Quantitative Ultra ...

ABSTRACT SignificanceGravesdiseaseGDone of the most prevalent autoimmune diseasesis caused by stimulating autoantibodiesTSAbto the Thyroid Stimulating Hormone ReceptorTSHRresulting in hyperthyroidismCurrent methods for managing hyperthyroidism in GD target excess thyroid hormone secretion by ablation or removal of the thyroid or by blocking thyroid hormone synthesisEach of these therapies is assoc ...

PROJECT SUMMARY ABSTRACT Over US adults and children are on mechanical ventilators in intensive care units each year While major advancements in ventilator devices have improved outcomes for critically ill patients current ventilator practice is predominately based on measurements of airway pressure The more relevant pressure particularly to determine if mechanical ventilation is causi ...

Project Summary Stem cell research has shown great potential to help treat or even cure a wide array of health conditions including cardiovascular and neurological disease cancer and diabetes This field is now beginning to move rapidly from the re search stage to clinical translation and commercial applications However it has been widely recognized that stem cell scientists have difficulty ...

PROJECT SUMMARY There is an increasing public concern about monitoring water quality in the entire drinking water supply system especially at the point of use spurred by recent water catastrophes such as the one in Flint Michigan that has caused severe health issues for thousands of children due to the unsafe level of lead in contaminated drinking water Current quantitative detection methods ...

An integrated measurement sensor for carbon-carbon (C-C) structures is needed for testing in arc jet facilities to meet testing needs for current and future hypersonic flight systems. A commercial-off-the-shelf (COTS) high frequency response pressure sensor and a fabricated temperature, heat flux, and recession sensor built directly into a C-C substrate will be integrated into a test article for ...

Plasmodium falciparum is the most virulent form of malaria causing million deaths per year Success with patient treatment and a malaria eradication campaign depends significantly on our ability to detect new infections as early as possible in the field rural areas including asymptomatic cases preferably using a small amount of blood e g from a finger prick and to clearly discrim ...

ABSTRACT Asomicsstudies become increasing commonnew methods to identify biomolecule interactions are neededThe ability to isolate specific biomolecules is a fundamental process that spans many biomedical sectors including researchdiagnosticsdrug discoveryand biomarker developmentCommonlysuch isolations are performed by capturing the analyte of interest on a solid structure and then washing away un ...

Space platforms are complex dynamical systems and there are many reasons to model them from ground telescope imagery as well as from space-based sensor platforms. One key motivation is to determine the operational state and configuration of the vehicle. Key questions such as did the solar panels fail to deploy, did the object begin to tumble unexpectedly may be addressed by a sufficiently detaile ...