Award Data

Project Summary This study aims to prove the concept and feasibility that TendonCure extracellular vesicles that contain signaling molecules i e exosomes secreted by mesenchymal stem cells i e tendon stem progenitor cells TSPCs or adipose derived stem cells ADSCs from individual patients donors cultured on a novel scaffold exert therapeutic efficacy on tendinopathy when injected into ...

PROJECT SUMMARY Lysosomal storage diseases LSD are rare inherited metabolic disorders caused by defects in the cellular catabolic system Mucopolysaccharidosis Type IIIC MPS IIIC or Sanfilippo disease type C is one such LSD that is caused by deficiency of the enzyme heparan sulfate acetyl CoA glucosaminide N acetyltransferase HGSNAT essential for degradation of heparan sulfate a repeati ...

Project Summary Tractions exerted by individual cells on their surroundings play a critical role in mechanical events in biology such as tissue contraction folding cell shape changes or cell movements and in many basic cellular functions such as biochemical signaling proliferation and differentiation These processes are in turn implicated in the progression of diseases like cancer atherosc ...

Abstract The overall goal of this proposal is to develop systems for efficient ex vivo maturation of functional human red blood cells RBCs which holds tremendous potential for addressing supply bottlenecks for delivering new therapeutic options to chronically transfused patients with severe alloimmunization and for novel strategies for delivering therapeutics via engineered RBCs No approaches ...

Automatic high-value target trackers have a number of uses, including real-time sensor slewing on user-nominated targets, offline forensic investigations into where a specific target traveled, and assisting with automated missions running on remote platforms. Instead of automatically tracking all targets within a scene, it can be beneficial to focus on a single or small number of critical targets ...

Space platforms are complex dynamical systems and there are many reasons to model them from ground telescope imagery as well as from space-based sensor platforms. One key motivation is to determine the operational state and configuration of the vehicle. Key questions such as did the solar panels fail to deploy, did the object begin to tumble unexpectedly may be addressed by a sufficiently detaile ...

There is a DoD need for the development of robust sensors to obtain temporally and spatially resolved surface temperature and heat flux measurements on test articles in blowdown and continuous hypersonic wind tunnels. These micro-heat flux sensors are required in order to better understand the state of the boundary layer of a hypersonic vehicle; to better understand boundary layer instabilities; a ...

In the growing demand for advanced hypersonic propulsion testing, ground testing diagnostics, a crucial element in minimizing risk in future test flight programs, have lagged behind. Current performance instruments rely on decades-old designs and require complex actively water-cooled systems that are prohibitively expensive and affect in-situ measurements. To deliver uniform and accurate flow fiel ...

The proposed effort involves the development of improved calibration concepts and techniques for several class of sensors and instruments that are in use by the Air Force in high speed test facilities. While specific sensors and instruments will be targeted during the core of the effort, it is also proposed to develop a high level tool that assists in the overall calibration process by helping id ...

Project SummaryA Novel Polymeric Valve for Transcatheter Aortic Valve Replacement Minimally invasive transcatheter aortic valve replacementTAVRhas emerged as an effective therapy for the unmet clinical need of inoperable patients with severe aortic stenosisASRecent longitudinal follow up studies of TAVR patients however indicate that this procedure and associated technology may result in serious a ...