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ABSTRACT Approximately million individuals suffer from traumatic brain injury TBI annually with over expected to die as a result of their injury In these most severe cases patients are typically admitted to the intensive care unit ICU for continuous monitoring and treatment of their injury Standard monitoring includes implantation of an intracranial pressure ICP sensor arterial ...

Multiple myeloma is incurable hematologic malignancy with an expected median survival of years The proteasome inhibitors bortezomib carfilzomib and the recently approved ixazomib are a mainstay of current myeloma treatment Despite an initial response rate approaching to proteasome inhibitor containing combinations all patients relapse and eventually become resistant to any treatments ...

Project Summary Rodent borne viral outbreaks are increasing in both frequency and impactAs weather patterns evolverodent populations are affected and may multiply in areas where increased contact with humans results in infectionHantavirusesincluding AndesANDVand Sin NombreSNVare transmitted through the excreta of infected rodents andwhen aerosolizedinfect humansIn the Americashantavirus infection ...

Space platforms are complex dynamical systems and there are many reasons to model them from ground telescope imagery as well as from space-based sensor platforms. One key motivation is to determine the operational state and configuration of the vehicle. Key questions such as did the solar panels fail to deploy, did the object begin to tumble unexpectedly may be addressed by a sufficiently detaile ...

Improved temperature measurements of thermal barrier coating (TBC) components are needed for gas turbine research and development.Imaging pyrometry systems are preferred because they are non-contact and can measure the complex spatial temperature distribution on components.Measurement in the long-wave infrared (LWIR) band is required for accurate temperature measurements of modern TBCs.Fiber coupl ...

DESCRIPTION provided by applicant Clinical Importance Almost million dental implants were placed worldwide in with million of these procedures taking place in the United States The worldwide market for these implants is expected to increase to $ $ billion in revenue by as dental implant manufactures target and train general dentists non surgically trained to perform th ...

DESCRIPTION provided by applicant Antibiotic resistance complicates the majority of Staphylococcus aureus S aureus infections as a full two thirds of hospital associated S aureus infections and of those acquired in the community are now methicillin resistant MRSA MRSA causes andgt infections in the US each year and it is responsible for half of all deaths caused by drug re ...

DESCRIPTION (provided by applicant): Over the last three decades the number of men diagnosed with prostate cancer has increased 85% as a result of new screening and diagnostic tools. However, a significant number of these newly diagnosed men are harboringclinically insignificant disease, which means that they are not likely to die from prostate cancer. A difficul decision facing urologists daily i ...

DESCRIPTION (provided by applicant): Disadvantaged, urban, and minority children incur a disproportionate share of asthma prevalence and morbidity. Interventions have been shown to improve underrepresented minority (URM) youths' adherence to NIH asthma care guidelines (e.g., proper use of long-term control medication) thereby reducing asthma morbidity. One particularly promising method of int ...