Award Data

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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until September, 2020.

  1. A novel product for tendinopathy treatment


    Project Summary This study aims to prove the concept and feasibility that TendonCure extracellular vesicles that contain signaling molecules i e exosomes secreted by mesenchymal stem cells i e tendon stem progenitor cells TSPCs or adipose derived stem cells ADSCs from individual patients donors cultured on a novel scaffold exert therapeutic efficacy on tendinopathy when injected into ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  2. Structure based optimization of a novel pharmacological chaperone therapy for MPSIIIC

    SBC: Phoenix Nest Inc.            Topic: NICHD

    PROJECT SUMMARY Lysosomal storage diseases LSD are rare inherited metabolic disorders caused by defects in the cellular catabolic system Mucopolysaccharidosis Type IIIC MPS IIIC or Sanfilippo disease type C is one such LSD that is caused by deficiency of the enzyme heparan sulfate acetyl CoA glucosaminide N acetyltransferase HGSNAT essential for degradation of heparan sulfate a repeati ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  3. Innovative Tools for Three Dimensional Traction Force Microscopy of Single Cells

    SBC: SIMMETRIX INC.            Topic: 102

    Project Summary Tractions exerted by individual cells on their surroundings play a critical role in mechanical events in biology such as tissue contraction folding cell shape changes or cell movements and in many basic cellular functions such as biochemical signaling proliferation and differentiation These processes are in turn implicated in the progression of diseases like cancer atherosc ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  4. Microfabrication based Biomimetic Approach for In Vitro Red Blood Cell Maturation

    SBC: Simpore Inc.            Topic: NHLBI

    Abstract The overall goal of this proposal is to develop systems for efficient ex vivo maturation of functional human red blood cells RBCs which holds tremendous potential for addressing supply bottlenecks for delivering new therapeutic options to chronically transfused patients with severe alloimmunization and for novel strategies for delivering therapeutics via engineered RBCs No approaches ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  5. General Online Object Deep (GOOD) Tracking

    SBC: Kitware, Inc.            Topic: AF17AT027

    Automatic high-value target trackers have a number of uses, including real-time sensor slewing on user-nominated targets, offline forensic investigations into where a specific target traveled, and assisting with automated missions running on remote platforms. Instead of automatically tracking all targets within a scene, it can be beneficial to focus on a single or small number of critical targets ...

    STTR Phase I 2017 Department of DefenseAir Force
  6. Bayesian Inference of Spacecraft Geometry and Pose

    SBC: VISION SYSTEMS INC.            Topic: AF17AT007

    Space platforms are complex dynamical systems and there are many reasons to model them from ground telescope imagery as well as from space-based sensor platforms. One key motivation is to determine the operational state and configuration of the vehicle. Key questions such as did the solar panels fail to deploy, did the object begin to tumble unexpectedly may be addressed by a sufficiently detaile ...

    STTR Phase I 2017 Department of DefenseAir Force
  7. Fast Response Heat Flux Sensors and Efficient Data Reduction Methodology for Hypersonic Wind Tunnels

    SBC: Innoveering, LLC            Topic: AF17AT001

    There is a DoD need for the development of robust sensors to obtain temporally and spatially resolved surface temperature and heat flux measurements on test articles in blowdown and continuous hypersonic wind tunnels. These micro-heat flux sensors are required in order to better understand the state of the boundary layer of a hypersonic vehicle; to better understand boundary layer instabilities; a ...

    STTR Phase I 2017 Department of DefenseAir Force
  8. Ultra Harsh Environment YSZ Sensor for Hypersonic Testing Facilities

    SBC: Innoveering, LLC            Topic: AF17AT002

    In the growing demand for advanced hypersonic propulsion testing, ground testing diagnostics, a crucial element in minimizing risk in future test flight programs, have lagged behind. Current performance instruments rely on decades-old designs and require complex actively water-cooled systems that are prohibitively expensive and affect in-situ measurements. To deliver uniform and accurate flow fiel ...

    STTR Phase I 2017 Department of DefenseAir Force
  9. Improved Calibration of Sensors and Instruments used for Measurement of High Speed Flow

    SBC: Innoveering, LLC            Topic: AF17AT003

    The proposed effort involves the development of improved calibration concepts and techniques for several class of sensors and instruments that are in use by the Air Force in high speed test facilities. While specific sensors and instruments will be targeted during the core of the effort, it is also proposed to develop a high level tool that assists in the overall calibration process by helping id ...

    STTR Phase I 2017 Department of DefenseAir Force
  10. Mass Spectrometric Screening of the Effect of Chemical Toxicants on the Human Epitranscriptome during Stem Cell Differentiation

    SBC: ATHGHIN BIOTECHNOLOGY, INC.            Topic: 113

    DESCRIPTION provided by applicant Epitranscriptomics explores levels and evolution of RNA modifications as a response from intra and inter cellular stimuli These modifications and the levels at which they are present are emerging as important regulators of biological processes Perturbations such as chemical toxicants exposure can alter the patterns of specific modifications on RNA sub types ...

    STTR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
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