Award Data

Multiple myeloma is incurable hematologic malignancy with an expected median survival of years The proteasome inhibitors bortezomib carfilzomib and the recently approved ixazomib are a mainstay of current myeloma treatment Despite an initial response rate approaching to proteasome inhibitor containing combinations all patients relapse and eventually become resistant to any treatments ...

PROJECT SUMMARY Computed tomography is used in about million imaging studies per year in the USA Iodinated contrast agents are used in roughly half of these studies Computed tomography is particularly important for the diagnosis of coronary artery disease where it depends on the use of iodinated contrast agents to visualize the arteries However these agents have a number of shortcomings s ...

Incisional hernia IH can be prevented using prophylactic mesh placement PMP which involved placement of mesh to reinforce an abdominal fascia closure before herniation occurs at the index of surgery PMP reduced the absolute risk of IH with an acceptable complication profile Open abdominal surgery techniques remain commonplace and contribute to the estimated cases of IH performed in ...

There has been growing interest in the use of antibody drug conjugates ADCs for the treatment of cancer as mounting data suggests an increase in anti tumor effectiveness and reduced toxicity compared with the administration of unlabeled antibodies in combination with chemotherapy The two ADCs that are currently approved by the FDA brentuximab vedotin Adcetris and ado trastuzumab emtansin ...

Space platforms are complex dynamical systems and there are many reasons to model them from ground telescope imagery as well as from space-based sensor platforms. One key motivation is to determine the operational state and configuration of the vehicle. Key questions such as did the solar panels fail to deploy, did the object begin to tumble unexpectedly may be addressed by a sufficiently detaile ...

Project Summary Rodent borne viral outbreaks are increasing in both frequency and impactAs weather patterns evolverodent populations are affected and may multiply in areas where increased contact with humans results in infectionHantavirusesincluding AndesANDVand Sin NombreSNVare transmitted through the excreta of infected rodents andwhen aerosolizedinfect humansIn the Americashantavirus infection ...

PROJECT SUMMARY We previously demonstrated in mice that the major pathogenic features eosinophilic airway inflammation and airway hyperresponsiveness AHR were markedly enhanced in mice exposed to repeated social stress and these changes were associated with impaired glucocorticoid receptor GR expression and function In studies on non human primates rhesus macaques at the California Natio ...

The design and development of a number of advanced Air Force propulsion systems is substantially limited by the current inability of computational design support tools to adequately and cost-effectively predict the complex flow physics and combustion dynamics that governs system performance and stability. The innovation proposed consists of a comprehensive experimental-modeling framework to (i) sy ...

Improved temperature measurements of thermal barrier coating (TBC) components are needed for gas turbine research and development.Imaging pyrometry systems are preferred because they are non-contact and can measure the complex spatial temperature distribution on components.Measurement in the long-wave infrared (LWIR) band is required for accurate temperature measurements of modern TBCs.Fiber coupl ...

The goal of this Phase I STTR grant application is to capitalize on our recent discovery of novel sulfide quinone oxidoreductase SQOR inhibitors by the design and preparation of new analogs for the treatment of heart failure that enable us to understand SAR so as to improve potency and optimize ADME PK properties Heart failure is a highly lethal disease affecting more than million adults in t ...