Award Data

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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until September, 2020.

  1. Mitochondrial Targeted Nano antioxidants to Treat Alzheimer s Disease

    SBC: Acelerox, LLC            Topic: NIA

    ABSTRACT PROJECT SUMMARY Alzheimer s disease AD is characterized by hyperphosphorylated tau protein which causes impaired axonal transport in neurons In recent years multiple researchers have determined that oxidative stress appears to be a significant early event in the pathogenesis of AD in preclinical AD models and in AD patients We have shown that reducing oxidative stress through quench ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  2. Developing an automated yeast dissection system for aging research

    SBC: Innovative BioChips LLC            Topic: NIA

    Project Summary Developing an Automated Yeast Dissection System for Aging Research Aging is the single greatest risk factor for diseases that are principal causes of mortality The objectives of aging research are to discover key genes and pathways related to aging that may eventually contribute to retardation of aging and a delay in the onset of age associated diseases The budding yeast Sacchar ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  3. Raising the Therapeutic Index of Photodynamic Therapy with Targeted Nanosyringes

    SBC: NANOHYBRIDS INC            Topic: 102

    ABSTRACT Current clinical photodynamic therapy PDT is an effective cancer treatment that is non invasive and low cost but it has yet to become a mainstream frontline treatment The clinical efficacy of PDT in solid tumors depends on significant accumulation of the photosensitizer PS at the tumor site availability of oxygen near the photosensitizer and effective dosing of the drug light c ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  4. Methamphetamine vaccine for Humans

    SBC: Kadvax Technologies, Inc            Topic: NIDA

    Methamphetamine MA use disorder is a major problem for over million people world wide with no FDA approved pharmacotherapy However anti addiction drug vaccines hold promise by inducing drug specific antibodies that form antibody MA complexes in the blood which are too large to cross the blood brain barrier thus reducing the rate and quantity of MAandapos s brain entry This inhibits MAan ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  5. A Cloud based Application for the Joint Analysis of Multiple Big Data Types

    SBC: MathNimbus Inc            Topic: 400

    Project Summary Technology advances now enable the cost effective acquisition of Kandgt distinct data types from a common set of N bio samples where i the kth data type is represented by a data matrix with columns containing Pk measurements in N samples for k K and ii at least one of the data types is big i e Pk is much bigger than N for some k The rapid accumulation of such mult ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  6. Thermal Monitoring of Quantum Cascade Lasers Using Scanning Near-Field Infrared Radiometry With Sub-Wavelength Resolution

    SBC: Max-IR Labs, LLC            Topic: AF17AT026

    Max-IR Labs, LLC., proposes a Phase I STTR program in conjunction with the University of Texas at Dallas to demonstrate the feasibility of the design, development, and production of scanning near-field infrared temperature sensor for thermal mapping of small heat sources. The specific application of the proposed instrument is targeted towards the optimization of the design of Quantum Cascade Laser ...

    STTR Phase I 2017 Department of DefenseAir Force
  7. Flexible Broad-band Optical Device

    SBC: NANOHMICS INC            Topic: AF17AT010

    Optical characterization of materials has remained an active area of research for many decades. With each advancement in light sources, detector technologies, microscopy, or compact spectroscopic analysis, a renewed effort is made to apply these technologies to material characterization, especially for biological tissues. There is a current need to characterize the details of the interaction of ...

    STTR Phase I 2017 Department of DefenseAir Force
  8. Bayesian Inference of Spacecraft Geometry and Pose

    SBC: VISION SYSTEMS INC.            Topic: AF17AT007

    Space platforms are complex dynamical systems and there are many reasons to model them from ground telescope imagery as well as from space-based sensor platforms. One key motivation is to determine the operational state and configuration of the vehicle. Key questions such as did the solar panels fail to deploy, did the object begin to tumble unexpectedly may be addressed by a sufficiently detaile ...

    STTR Phase I 2017 Department of DefenseAir Force
  9. Development of PTI DX a blood based diagnostic for Alzheimer s disease

    SBC: PAIN THERAPEUTICS, INC.            Topic: NIA

    Abstract PTI is developing PTI DX a novel quantitative blood based diagnostic candidate for Alzheimerandapos s disease AD A non invasive and inexpensive AD diagnostic is sorely needed particularly one with the ability to detect early pathological changes that precede cognitive symptoms PTI DX measures the ratio of two protein fragments in plasma and is a companion diagnostic biomark ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  10. Optical Diagnostics and Analysis for Multiphase Blast

    SBC: PROTECTION ENGINEERING CONSULTANTS LLC            Topic: AF17AT020

    The damage mechanisms induced by multi-phase blast weapons are not well understood. This is due to the complexity of the phenomenologies associated with weapon effects and also the difficulties associated with measuring and quantifying such phenomena under testing conditions. The proposed Phase I effort will develop an optical imaging and image analysis approach to identify and quantify multi-pha ...

    STTR Phase I 2017 Department of DefenseAir Force
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