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The Award database is continually updated throughout the year. As a result, data for FY20 is not expected to be complete until September, 2021.

  1. A Randomized Blinded Placebo Controlled Clinical Trial to Evaluate Longeveron Mesenchymal Stem Cell LMSC Therapy for Treating The Metabolic Syndrome

    SBC: Longeveron LLC            Topic: NIA

    The metabolic syndrome MetS is a cluster of factors that increases the risks for cardiovascular disease type diabetes mellitus and mortality and currently affects andgt of US adults MetS is associated with endothelial dysfunction decreased circulating endothelial progenitor cells EPCs and a pro inflammatory state We have made the exciting discovery that therapy with allogeneic me ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  2. Optimizing electrical impedance myography outcomes through data mining

    SBC: Myolex Inc            Topic: NIAMS

    Project summary Electrical impedance myography EIM is a non invasive technology for the assessment of muscle that is based on the application of a weak high frequency electrical current to a muscle and the measurement of the resulting surface voltages The further development and application of EIM remains the main business focus of Skulpt Inc a small business concern based in Boston and San ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  3. Functional integrated human on a chip systems for Alzheimer s research

    SBC: Hesperos, Inc.            Topic: NIA

    Project Summary The goal of this proposal at the end of the Phase II effort is to have a service available to academia and industry to screen drugs for Alzheimer s to predict patient outcomes and determine how potential therapeutics are delivered to the CNS There are currently few companies able to offer multi organ evaluation with a recirculating medium utilizing functional readouts and none ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  4. Integration of a kidney module into a organ human on a chip system

    SBC: Hesperos, Inc.            Topic: 400

    Project Summary Our overall strategy for Hesperos is to utilize microphysiological systems in combination with functional readouts to establish platforms capable of sophisticated analysis of chemicals and drug candidates for toxicity and efficacy during pre clinical testing with initial emphasis on predictive toxicity This is a service based company and is developing low cost in vitro systems u ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  5. Preclinical characterization of THR to induce pancreatic beta cell regeneration Phase I

    SBC: Ophysio Inc.            Topic: NIDDK

    The exocrine acinar ductal compartment of the pancreas has been hypothesized to harbor progenitor cells with the ability to give rise to new b cells The activation of such progenitors may potentially result in new b cell formation through differentiation rather than reprogramming We hypothesized that if pancreatic progenitors existed they would respond to bone morphogenetic protein BMP ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  6. Probabilistic Modeling for Software Guided Radiotherapy Patient Plan QA

    SBC: SUN NUCLEAR CORP.            Topic: 103

    Errors in the planning and delivery of radiation therapy can result in inferior outcomes for patients The magnitude of this problem is now well appreciated from cooperative group trials and other sources At present however there are few concrete tools to reduce the chance of plan errors passing undetected Current practice uses a variety of error mitigation means such as human inspection of th ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  7. Development of AAV vectors for long term expression of eCD Ig

    SBC: EMMUNE, INC.            Topic: NIAID

    ABSTRACT SUMMARY PROJECT DESCRIPTION A single intramuscular injection of an adeno associated virus AAV vector that expresses eCD Ig has the potential to treat or prevent HIV infection for a lifetime eCD Ig is a synthetic antibody or immunoadhesin constructed by fusing parts of the viral receptor CD and coreceptor CCR to the constant region of an antibody Because eCD Ig binds t ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  8. Oxidative Stress Biosensor for Breath Based Environmental Monitoring

    SBC: ISENSE, LLC            Topic: NIEHS

    PROJECT SUMMARY ABSTRACT This application seeks to develop a non invasive and practical optical sensor technology to monitor and quantify oxidative health Oxidative stress OS is a biochemical imbalance in which production of reactive oxygen species exceeds the system s antioxidant capacity Failure to repair or contain cumulative oxidative damage is likely responsible for the pathogenesis of ma ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  9. Therapeutic Administration of Suppressor of Cytokine Signaling Mimetics to Ameliorate Type Diabetes

    SBC: ONEVAX, LLC            Topic: NIAID

    Type Diabetes T D results from a breakdown of self tolerance that is characterized by immune cell mediated destruction of the insulin producing cells in the pancreas Ultimately glucose metabolism is interrupted resulting in the development of life threatening complications such as heart disease and renal failure T D affects an estimated million Americans with more than new patie ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  10. Learner Engagement and Motivation to Learn Assessment and Monitoring System

    SBC: Design Interactive, Inc            Topic: AF17AT009

    Training can now delivered on a large scale through platforms, but must be engaging to be effectively utilized. Key to providing training that makes a difference in the field is an understanding of how to induce high levels or engagement during learning, and the ability to objectively assess engagement in real-time so that interventions can be tailored during training to optimize engagement and m ...

    STTR Phase I 2017 Department of DefenseAir Force
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