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The Award database is continually updated throughout the year. As a result, data for FY20 is not expected to be complete until September, 2021.

  1. Cellular Immunotherapy for SSc

    SBC: CELDARA MEDICAL, LLC            Topic: NIAMS

    Project Summary Systemic sclerosis SSc is a systemic autoimmune disease that results in widespread fibrosis of the skin and internal organs vascular dropout and autoantibody formation SSc has the highest case fatality rate of any systemic autoimmune disease and there remain for FDA approved therapies Analysis of gene expression data on samples collected from SSc patients strongly indicates th ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  2. Novel Inhibitors of PSMB and PSMB for the Treatment of Multiple Myeloma

    SBC: InhiProt            Topic: 103

    Multiple myeloma is incurable hematologic malignancy with an expected median survival of years The proteasome inhibitors bortezomib carfilzomib and the recently approved ixazomib are a mainstay of current myeloma treatment Despite an initial response rate approaching to proteasome inhibitor containing combinations all patients relapse and eventually become resistant to any treatments ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  3. Complex Dimensional in Vitro Human Skin Tissue Models for Scleroderma

    SBC: CELDARA MEDICAL, LLC            Topic: NIAMS

    Abstract Project Summary Scleroderma Systemic Sclerosis SSc is an autoimmune disease of unknown etiology that is characterized by vascular dysfunction fibrosis and inflammation One in three patients dies within years of diagnosis giving SSc the highest case fatality rate of any systemic autoimmune disease A lack of biologically relevant human SSc disease models has created a critical ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  4. Antimony-based LWIR detectors with low dark current and high quantum efficiency

    SBC: QmagiQ, LLC            Topic: AF171078

    QmagiQ, LLC proposes to fabricate and deliver for evaluation a number of small-format focal plane arrays (FPAs) of antimony-based strained layer superlattice (SLS) photodiodes with longwave infrared (LWIR) cutoff wavelengths ranging from 9 microns to 13 m

    SBIR Phase I 2017 Department of DefenseAir Force
  5. Bayesian Inference of Spacecraft Geometry and Pose

    SBC: VISION SYSTEMS INC.            Topic: AF17AT007

    Space platforms are complex dynamical systems and there are many reasons to model them from ground telescope imagery as well as from space-based sensor platforms. One key motivation is to determine the operational state and configuration of the vehicle. Key questions such as did the solar panels fail to deploy, did the object begin to tumble unexpectedly may be addressed by a sufficiently detaile ...

    STTR Phase I 2017 Department of DefenseAir Force
  6. Efficient, High-Pressure Ratio, Centrifugal Refrigerant Comperssor for Aircraft Thermal Management

    SBC: CREARE LLC            Topic: AF171057

    Adaptive hybrid thermal management technologies will significantly enhance the capability and range of next-generation aircraft. A critical need for this future adaptive thermal architecture is an advanced lightweight, compressor technology that can achi

    SBIR Phase I 2017 Department of DefenseAir Force
  7. LWIR Fiber Bundle for Thermal Imaging in Gas Turbine Systems

    SBC: CREARE LLC            Topic: AF17AT016

    Improved temperature measurements of thermal barrier coating (TBC) components are needed for gas turbine research and development.Imaging pyrometry systems are preferred because they are non-contact and can measure the complex spatial temperature distribution on components.Measurement in the long-wave infrared (LWIR) band is required for accurate temperature measurements of modern TBCs.Fiber coupl ...

    STTR Phase I 2017 Department of DefenseAir Force
  8. A Novel Composite Repair Modeling System

    SBC: CREARE LLC            Topic: AF171112

    Many new-generation military aircraft are fabricated from high-temperature polymer matrix composites (PMCs). The ability to effectively repair these aircraft in the field requires the use of patches that can be cured to specific temperature ranges, with

    SBIR Phase I 2017 Department of DefenseAir Force
  9. Video rate optical verification tool for radiotherapy treatment plans

    SBC: DoseOptics LLC            Topic: 393

    DESCRIPTION provided by applicant For the first time it is possible to directly visualize a radiation beam hitting a patientandapos s tissue or high resolution imaging of radiation delivery in water tank phantoms using Cerenkov emission imaging This allows the opportunity to do pre treatment verification at high resolution on patient verification of every delivered fraction or simply monit ...

    SBIR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  10. Preclinical development of inhalable glutaredoxin-1 for the treatment of IPF

    SBC: CELDARA MEDICAL, LLC            Topic: NHLBI

    DESCRIPTION provided by applicant Idiopathic pulmonary fibrosis IPF kills about persons in the United States each year There are currently around Americans afflicted with this fatal disease that typically results in death within years This year alone another approximately Americans will receive this devastating diagnosis While two recently approved drugs reduce the ...

    SBIR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
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