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Abstract Immunotherapy is one of the most promising approaches for treatment of various human diseases including cancers autoimmune and infectious diseases However systemic immunotherapies have been ineffective for central nervous system CNS disorders because the blood brain barrier BBB limits their delivery to the brain Development of new antibody agents able to overcome the BBB is a new ...

Project Summary Systemic sclerosis SSc is a systemic autoimmune disease that results in widespread fibrosis of the skin and internal organs vascular dropout and autoantibody formation SSc has the highest case fatality rate of any systemic autoimmune disease and there remain for FDA approved therapies Analysis of gene expression data on samples collected from SSc patients strongly indicates th ...

Multiple myeloma is incurable hematologic malignancy with an expected median survival of years The proteasome inhibitors bortezomib carfilzomib and the recently approved ixazomib are a mainstay of current myeloma treatment Despite an initial response rate approaching to proteasome inhibitor containing combinations all patients relapse and eventually become resistant to any treatments ...

Abstract Project Summary This proposed supplement expands the commercialization and market assessment activities for the original Phase I grant through the Innovation CORPs Program at NIHThe expected primary benefit from I Corps is having dedicated time and mentored direction towards relevant interviews in the endoscopic spacethis is expected to provide invaluable information about the needsin dep ...

We propose to create a modular suite of products that will make highly multiplexed imaging of individual cells in intact tissue available to a wide range of laboratories through validated labeling kits and companion imaging software that promotes discovery through interactive image and data visualization Our goal is to create a suite of integrated labeling display and analysis products to elucid ...

This project will provide the first ground truth connection anisotropic diffusion phantom to reproduce human white matter using axon scale diffusion tubes and track micron scale fascicle bundles of axons with a common path The phantom will advance MR diffusion imaging providing accurate calibration quality assurance and research advancement It utilizes innovations in textile engineering ...

ABSTRACT SignificanceGravesdiseaseGDone of the most prevalent autoimmune diseasesis caused by stimulating autoantibodiesTSAbto the Thyroid Stimulating Hormone ReceptorTSHRresulting in hyperthyroidismCurrent methods for managing hyperthyroidism in GD target excess thyroid hormone secretion by ablation or removal of the thyroid or by blocking thyroid hormone synthesisEach of these therapies is assoc ...

PROJECT SUMMARY Computed tomography is used in about million imaging studies per year in the USA Iodinated contrast agents are used in roughly half of these studies Computed tomography is particularly important for the diagnosis of coronary artery disease where it depends on the use of iodinated contrast agents to visualize the arteries However these agents have a number of shortcomings s ...

Abstract An exciting and promising new avenue for cancer treatment is the inhibition of immune evasion the employment by tumors of various strategies to suppress the host immune system s ability to recognize and destroy cancer cells Immunotherapies including monoclonal antibodies transplanted stem cells and engineered T cells vaccines cytokines and T cell checkpoint blockers have shown ef ...

Project Summary ONC is a selective antagonist of the G protein coupled receptor GPCR dopamine receptor domain DRD that is overexpressed in endometrial cancer EC due to its p independent control of the Akt ERK signaling pathways ONC is a first in class small molecule exhibits anticancer efficacy in a wide range of refractory cancers including p mutant cells by simultaneously i ...