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Project Summary Systemic sclerosis SSc is a systemic autoimmune disease that results in widespread fibrosis of the skin and internal organs vascular dropout and autoantibody formation SSc has the highest case fatality rate of any systemic autoimmune disease and there remain for FDA approved therapies Analysis of gene expression data on samples collected from SSc patients strongly indicates th ...

Multiple myeloma is incurable hematologic malignancy with an expected median survival of years The proteasome inhibitors bortezomib carfilzomib and the recently approved ixazomib are a mainstay of current myeloma treatment Despite an initial response rate approaching to proteasome inhibitor containing combinations all patients relapse and eventually become resistant to any treatments ...

ABSTRACT SignificanceGravesdiseaseGDone of the most prevalent autoimmune diseasesis caused by stimulating autoantibodiesTSAbto the Thyroid Stimulating Hormone ReceptorTSHRresulting in hyperthyroidismCurrent methods for managing hyperthyroidism in GD target excess thyroid hormone secretion by ablation or removal of the thyroid or by blocking thyroid hormone synthesisEach of these therapies is assoc ...

Abstract Project Summary Scleroderma Systemic Sclerosis SSc is an autoimmune disease of unknown etiology that is characterized by vascular dysfunction fibrosis and inflammation One in three patients dies within years of diagnosis giving SSc the highest case fatality rate of any systemic autoimmune disease A lack of biologically relevant human SSc disease models has created a critical ...

QmagiQ, LLC proposes to fabricate and deliver for evaluation a number of small-format focal plane arrays (FPAs) of antimony-based strained layer superlattice (SLS) photodiodes with longwave infrared (LWIR) cutoff wavelengths ranging from 9 microns to 13 m

Space platforms are complex dynamical systems and there are many reasons to model them from ground telescope imagery as well as from space-based sensor platforms. One key motivation is to determine the operational state and configuration of the vehicle. Key questions such as did the solar panels fail to deploy, did the object begin to tumble unexpectedly may be addressed by a sufficiently detaile ...

Project Summary Rodent borne viral outbreaks are increasing in both frequency and impactAs weather patterns evolverodent populations are affected and may multiply in areas where increased contact with humans results in infectionHantavirusesincluding AndesANDVand Sin NombreSNVare transmitted through the excreta of infected rodents andwhen aerosolizedinfect humansIn the Americashantavirus infection ...

Adaptive hybrid thermal management technologies will significantly enhance the capability and range of next-generation aircraft. A critical need for this future adaptive thermal architecture is an advanced lightweight, compressor technology that can achi

Improved temperature measurements of thermal barrier coating (TBC) components are needed for gas turbine research and development.Imaging pyrometry systems are preferred because they are non-contact and can measure the complex spatial temperature distribution on components.Measurement in the long-wave infrared (LWIR) band is required for accurate temperature measurements of modern TBCs.Fiber coupl ...

Many new-generation military aircraft are fabricated from high-temperature polymer matrix composites (PMCs). The ability to effectively repair these aircraft in the field requires the use of patches that can be cured to specific temperature ranges, with