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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Pharmacologic Suppression of Reperfusion Injury Following Endovascular Thrombectomy In Stroke.

    SBC: BIOMIMETIX JV LLC            Topic: 102

    Ischemic stroke is a leading cause of death and disability in the United StatesThis often is attributable to thrombus formation at an atherosclerotic plaque or thromboembolismPatients who present withinhours of symptom onset are eligible for thrombolysis with tissue plasminogen activatortPAThis serves andltof victimsRecentlymajor advance has been made with proven efficacy from endovascular mechani ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  2. An Advanced Lung Organomimetic to Reproduce Human Airway Pathophysiology

    SBC: Pneumax, LLC            Topic: 113

    PROJECT SUMMARYThree of top five causes of death in humans globally are lung relatedchronic obstructive pulmonary diseaseCOPDlower respiratory infections and lung cancers collectively account for over eight million deaths annuallyCurrentlyin preclinical settingstatic cell cultures and animal models are the most widely used systems for mechanistic and translational studiesHowevercritical limitation ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  3. Development of a lead cyclic-PDZ-Enhancer drug for Anxiety and Depression

    SBC: Aingeal, LLC            Topic: 101

    Major depressive disorder is a debilitating mood disorder that affectsof US adults in their lifetimecosting the U Seconomy more than $billion a yearDrugs that increase monoaminergic signaling are the mainstay of depression therapybut have a delayed onset of action and are only effective in aboutof affected patientsAberrant brain derived neurotrophic factorBDNFsignaling has been proposed to underli ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  4. Reference standards for quality control and data validation in microbiome studies

    SBC: Biocollective, LLC, The            Topic: 400

    Contact PD PICanoRaul JCompanyThe BioCollectiveLLCApplication IdentifierFOAPASUMMARY Significant advances in high throughput sequencing and new tools for analyzing microbiomes as well as the demonstrated value of microbiome research in human health are driving rapid development in this fieldThis rapid and exponential increase in microbiome related studieshoweveremploys a stochasticnon standardized ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  5. Novel drugs combinations for improving survival from Acute Radiation Syndrome when administered 48h postirradiation

    SBC: Bolder Biotechnology, Inc.            Topic: NIAID

    AbstractBone marrow is one of the most radiation sensitive tissuesand patients acutely exposed to total body irradiationTBIdoses andgtGy develop severe neutropeniathrombocytopeniaanemiaand lymphopenia within days to weeks of exposureoften dying from infectionsdue to a lack of neutrophilsand uncontrolled bleedinginsufficient plateletsreferred to as the hematopoietic acute radiation syndromeor H ARS ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  6. Development of the first wireless near infrared spectroscopy device for preclinical monitoring of cerebral oxygenation

    SBC: Barati Medical, LLC            Topic: 102

    PROJECT SUMMARY Stroke is the fifth largest cause of death and a leading cause of long term disability among adults in the United StatesMore thanneuroprotective and thrombolytic drug candidates for ischemic stroke have failed in clinical trials betweenandraising concerns regarding the efficacy of preclinical studiesOur longterm goal is to improve the value of animal models of ischemic stroke and a ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  7. Human Milk Concentration Device; Point of Care Technology for Feeding Preterm Infants in Intensive Care

    SBC: MOTHER'S MILK IS BEST, INC.            Topic: NICHD

    Human milk is the best feeding option for preterm infantsHoweverdue to the high nutrient needs of preterm infants in US Neonatal Intensive Care UnitsNICUsthe mother s own milk is most often mixed with bovine milk sourced fortifiers to achieve goal nutrient levelsThe Human Milk ConcentrationHMCdevice concentrates a mother s milk by removing water so that preterm infants can receive adequate nutrien ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  8. The Point Digit: A ratcheting prosthetic finger using advanced rapid manufacturing technology

    SBC: POINT DESIGNS, LLC            Topic: NICHD

    The Point DigitA Ratcheting Prosthetic Finger UsingAdvanced Rapid Manufacturing Technology Project SummaryAbstract The goal of the proposed project is to develop and commercialize a purely mechanicalratcheting prosthetic fingerthe Point Digitwhichhas an industry leading strength to weight ratiocan be operated unilaterallyone handedoffers anatomical rotation and flexion around the patient s metacar ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  9. In Vivo Studies of a Novel HDAC Inhibitor for Treating Hemoglobin Disorders

    SBC: CETYA THERAPEUTICS, INC.            Topic: NHLBI

    PROJECT SUMMARY Thehemoglobinopathies are prevalent genetic blood diseases with few treatment optionsIt is estimate thatof the worldandapos s population carries an abnormal hemoglobin gene withinfants born annually with a severe life threatening hemoglobinopathyDrug mediated induction of normalbut developmentally silencedfetal hemoglobinHbFexpression reduces anemia and ameliorates clinical severit ...

    STTR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  10. A compact, modular two-photon fiber-coupled microscope for in vivo all-optical electrophysiology

    SBC: INTELLIGENT IMAGING INNOVATIONS, INC.            Topic: 101

    Good methods to interrogateand ideally perturbneural systems at the network level have been elusive until recentlyThe advent of biochemical breakthroughsnamely neuronally targeted genetically encoded calcium reporterssuch as GCaMPand light activated channelssuch as channelrhodopsinhave enabledall opticalelectrophysiology where experiments can be conducted that involve simultaneousor closely sequen ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health

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