Award Data

DESCRIPTION (provided by applicant): More than 25 million people in the United States suffer from neuropathic pain. Currently available drugs include opioids, anti-epileptics, topicals such as lidocaine, NMDA antagonists, and tricyclic antidepressants, none of which achieve clinical significance greater than 50%. To address this problem of significant clinical need and poor clinical significance, ...

DESCRIPTION (provided by applicant): Environmental factors such as toxins and pollutants are known to have a strong correlation to the incidence of various common human diseases. However, a critical shortcoming in quantitative studies of the correlation is the lack of robust, reliable, and inexpensive devices to measure the personal exposure to pollutants. Further, studies over extended periods of ...

If CO2 could be scrubbed from the flue gas of power plants and safely sequestered, the country¿s most important source of electricity, fossil-fired power plants, could operate without emitting significant amounts of greenhouse gases. Although technology for scrubbing CO2 from flue gas is commercially available, it is far too expensive and requires too much energy to be widely deployed. This pro ...

Secure sources of clean freshwater are essential to the welfare of communities throughout the world. Unfortunately, both in this country and abroad, freshwater supplies are increasingly being contested. Faced with threats to growth, economic development, and the health of their citizens, governments are battling over the rights to freshwater supplies. Desalination, particularly if it is powered ...

DESCRIPTION (provided by applicant): The long-term goal of the proposed research is to develop a novel quantitative particle agglutination technology for improving the performance of detection of human immunodeficiency virus (HIV) antibody in body fluids. The conventional particle agglutination assays have serious drawbacks such as limited sensitivity, long time of incubation, subjectivity and la ...

DESCRIPTION (provided by applicant): The long-term goal of the proposed research is to develop sensitive, specific and quantitative enzyme-linked immunosorbent assays (ELISA) for (1) measuring anti-RhD (anti-D) antibodies in patients at risk for Hemolytic Disease of the Newborn (HDN), (2) screening individuals who receive anti-D for prophylaxis of HDN, (3) qualitative assessment of anti-D preparat ...

DESCRIPTION (provided by applicant): The goal of this project is to develop a Colonoscopy Force Monitor (CFM), a handheld attachment mounted on the colonoscope shaft which provides a physician with real-time feedback on the force and torque applied during colonoscopy. The CFM is designed to improve the training of endoscopists, establish best practices for performing colonoscopy by quantitative ch ...

DESCRIPTION (provided by applicant): BCR Diagnostics, Inc. (BCR) has recently developed and patented a technology platform for engineering fluorogenic functionality into living Bacillus spores. Fluorogenic spores (F-spores) produced at BCR appear to be physiologically identical to normal spores except for performing as self-reporters of initial germination events. ...

Not avaiable.

DESCRIPTION (provided by applicant): Meta-analysis plays a key role in setting policy and in planning new research. In the field of substance abuse prevention, meta-analyses have been used to determine the relative impact of competing treatments for addict ion, to estimate prevalence of addiction-related diseases, to plan targeted interventions, to assess the cost-effectiveness of competing treatm ...