Award Data

DESCRIPTION (provided by applicant): Excessive alcohol use is associated with a range of serious and costly health, social, and economic consequences at the individual and societal level. This program of research serves as a venue by which to produce and test an innovative, science-based, and cost-effective means to intervene in a private, convenient, and individualized way with employed adults wh ...

DESCRIPTION (provided by applicant): Juvenile crime imposes enormous costs on victims, on society, and on juvenile offenders themselves. However, research assessing the efficacy of interventions for young offenders show, on average, only small effects on recidivism, substance abuse, and other behavioral outcomes. A major problem with existing interventions is that they tend to neglect individual d ...

DESCRIPTION (provided by applicant): The goal of this Phase II project is to advance the development of novel tolerance-inducing peptides (Tregitopes) to prevent and/or treat Type 1 diabetes (T1D) by optimizing the clinical delivery vehicle and treatment protocol, and by identifying correlates of efficacy in preparation for Phase 1 clinical trials. More than 13,000 children in the U.S. are diagnos ...

DESCRIPTION (provided by applicant): Many prescribed drugs exhibit drug-drug interactions due to up-regulation or inhibition of specific P450 enzymes. According to a recent guidance from the FDA, CYP1A2, CYP2B6, and CYP3A4 induction should be evaluated inat least an in vitro system. Enzymatic activity in freshly isolated hepatocytes is the Gold Standard for studying P450 induction; however, it ...

DESCRIPTION (provided by applicant): In this grant proposal An Automated Antisense Design and Simulation Platform , a comprehensive molecular diagnostics software tool that is specific to the design and simulation of antisense oligonucleotide analog probes will be developed. The application of antisense technologies to the study of human diseases has been proven in the literature for cancer, im ...

DESCRIPTION (provided by applicant): Congenital heart disease patients with functional single ventricle (FSV) anatomy usually require a series of surgeries during infancy and childhood in order to provide them with a chance to survive into adulthood. The second stage surgery, termed the hemi-Fontan procedure (HFP) re-routes systemic venous blood from the upper body and head into the pulmonary circ ...

DESCRIPTION (provided by applicant): Leukocytes (LE) are major contributors to the pathogenesis and progression of many clinical inflammatory disorders, including the systemic inflammatory response syndrome, sepsis and acute respiratory distress syndrome.The need for new and innovative therapies to treat these inflammatory disease states presents a large commercial market opportunity. A large numb ...

So-called tabletop accelerators are a holy-grail of high energy/high field physics and, if developed, as indicated by the Department of Energy in the Accelerators for America report, will spur a revolution in particle physics discoveries and also in medical treatments. This is because planned next-generation particle accelerators are still kilometers in size and billions of dollars to build and su ...

Superconducting radio frequency (SRF) accelerating cavities are being successfully used for acceleration of electron beams worldwide. The use of superconducting structures helps maximize the accelerating gradient, which is a highly desirable trait for applications involving linear accelerators or storage rings. Application of todays multi-spoke accelerating structures in future SRF electron lina ...

In the last ten to fifteen years, superconducting radio frequency cavities have begun to be utilized in accelerators for light sources, first as passive cavities for stabilizing the beam and later in the accelerating sections. In this SBIR proposal, Niowave will build and test the quarter-wave cavity design developed in Phase I of the SBIR. This new cavity system is simpler and less expensive to ...