Award Data

DESCRIPTION (provided by applicant): Excessive alcohol use is associated with a range of serious and costly health, social, and economic consequences at the individual and societal level. This program of research serves as a venue by which to produce and test an innovative, science-based, and cost-effective means to intervene in a private, convenient, and individualized way with employed adults wh ...

DESCRIPTION (provided by applicant): Juvenile crime imposes enormous costs on victims, on society, and on juvenile offenders themselves. However, research assessing the efficacy of interventions for young offenders show, on average, only small effects on recidivism, substance abuse, and other behavioral outcomes. A major problem with existing interventions is that they tend to neglect individual d ...

DESCRIPTION (provided by applicant): The goal of this Phase II project is to advance the development of novel tolerance-inducing peptides (Tregitopes) to prevent and/or treat Type 1 diabetes (T1D) by optimizing the clinical delivery vehicle and treatment protocol, and by identifying correlates of efficacy in preparation for Phase 1 clinical trials. More than 13,000 children in the U.S. are diagnos ...

DESCRIPTION (provided by applicant): There are an estimated 26 million Americans with early chronic kidney disease (CKD). Early diagnosis and treatment are the only cost-effective means to reverse this growing problem. NIH recognizes the challenge to diagnose CKD early during its initiation and development phases in order to prevent further renal damage, reduce cardiovascular risk, and minimize th ...

DESCRIPTION (provided by applicant): The baculovirus expression vector system (BEVS) is a proven, powerful and versatile method of eukaryotic protein expression. It is used to produce vaccines, diagnostics, and biologically active proteins for a multitudeof research projects. Like all expression systems, however, BEVS has its disadvantages. One is the fact that expression is short-lived due to vir ...

DESCRIPTION (provided by applicant): This FastTrack SBIR proposal aims to disseminate a Functional Electrical Stimulation (FES) technology for stroke ambulation and neuromotor rehabilitation. The FastFES paradigm integrates two rehabilitation approaches,fast-paced treadmill walking and FES, in a manner that has been shown to both improve gait kinematics when the stimulation is active and to impro ...

DESCRIPTION (provided by applicant): Heart failure (HF) remains one of the largest unsolved problems in health care today and continues to increase in incidence and cost ( 34.8 billion in US in 2008). Prognosis remains limited especially in patients with advanced heart failure. Transplantation is often the best option for patients with advanced HF whose hearts are not recoverable but is limited by ...

The U.S. EPA Stage 2 Disinfectants and Disinfection Byproducts Rule (S2DDBR) requires potable water utilities to maintain total trihalomethane (TTHM) concentrations below 80µg/L at all locations within distribution systems beginning in 2012 due to adverse health-effect risks. Air stripping effectively volatilizes TTHMs due to their low Henry’s law constants. However, commercially available ai ...

Okeanos Technologies is developing a desalination system that used Ion Concentration Polarization (ICP) elements and modular arrays. ICP can separate water from solutes and contaminants far more efficiently than Reverse Osmosis (RO) or Electrodialysis(ED) because no extreme hydraulic pressures or heat sources are needed. The improve efficiency translates into order of magnitude savings in operat ...

Current energy storage devices have energy densities that are barely sufficient for low cost electric-vehicles and rely on lithium ion batteries that use flammable, unsafe, liquid electrolytes. However, in order to replace liquid electrolyes in lithium batteries for hybrid electric power train systems, solid polymer electrolytes, which have the advantages of safety and flexibility, must attain con ...