Award Data

DESCRIPTION (provided by applicant): Excessive alcohol use is associated with a range of serious and costly health, social, and economic consequences at the individual and societal level. This program of research serves as a venue by which to produce and test an innovative, science-based, and cost-effective means to intervene in a private, convenient, and individualized way with employed adults wh ...

DESCRIPTION (provided by applicant): The proposed SBIR Phase II project aims at developing a new drug product, the naltrexone orally dissolving film (ODF), for treatment of alcohol dependence. The naltrexone ODF is a small, thin, and flexible film, containing naltrexone hydrochloride and other excipients. It is applied intra-orally and adheres to the oral mucosa to affect a rapid onset of action d ...

DESCRIPTION (provided by applicant): In this Phase II SBIR project, Concordance Health Solutions (CHS) will continue development of the ScanCap System and test its effectiveness on adherence rates and hypertension patient outcomes The ScanCap System is anelectronic reminder cap that is seamlessly programmed at the pharmacy and incorporated into original packaging for prescription medications. The ...

DESCRIPTION (provided by applicant): It is hypothesized that the use robotic rehabilitation tables coupled with virtual reality games with elderly stroke survivors residents in skilled nursin facilities (SNFs) will: 1) improve and maintain upper extremityuni-manual and bimanual function, reach, strength and ADL independence; 2) improve and maintain cognition (memory, focus, problem solving); and ...

DESCRIPTION (provided by applicant): SBIR 1R43AR060019 Phase II application: Protein Therapeutics for Muscular Dystrophy Principal Investigator: Takizawa, Norio Project Summary: This application requests for a Phase II project for our initial SBIR grant addressing the use of a novel protein therapeutic agent, MG53, for the treatment of muscular dystrophy (1R43AR060019). Our Phase I studi ...

DESCRIPTION (provided by applicant): Juvenile crime imposes enormous costs on victims, on society, and on juvenile offenders themselves. However, research assessing the efficacy of interventions for young offenders show, on average, only small effects on recidivism, substance abuse, and other behavioral outcomes. A major problem with existing interventions is that they tend to neglect individual d ...

DESCRIPTION (provided by applicant): Dentin forms the bulk of the tooth and is covered by enamel in the crown of the tooth and cementum in the root. When dental caries breaks down enamel and involves the dentin, the patient experiences pain and thermal sensitivity. The acute phase of dental pulp infection is typically associated with excruciating pain, and if not properly managed, can lead to per ...

DESCRIPTION (provided by applicant): The goal of this Phase II project is to advance the development of novel tolerance-inducing peptides (Tregitopes) to prevent and/or treat Type 1 diabetes (T1D) by optimizing the clinical delivery vehicle and treatment protocol, and by identifying correlates of efficacy in preparation for Phase 1 clinical trials. More than 13,000 children in the U.S. are diagnos ...

DESCRIPTION (provided by applicant): An estimated 23.6 million people (7 percent of the population) in the United States have diabetes; 90 to 95 percent of all diagnosed cases are type 2 diabetes (CDC, 2007). Obesity and metabolic syndrome are the leadingcauses of type 2 diabetes. The search for new and more effective therapies to address the growing number of Americans with type 2 diabetes and re ...

DESCRIPTION (provided by applicant): The clinical significance of chronic pro-inflammatory reactions in dialysis patients due to exposure to endotoxin has become a central issue in nephrology. The European Renal Association urges the routine use of ultrapure dialysate with bacteria and endotoxin levels of lt 0.1 CFU/ml and lt 0.03 EU/ml, respectively. In the US, the maximum allowable limit of ba ...