Award Data

DESCRIPTION (provided by applicant): Based upon newly discovered mechanisms to enhance circulation during CPR, the goal of this SBIR phase 1 application is to develop a comprehensive and novel non-invasive extracorporeal automated circulatory assist device to normalize blood flow during cardiac arrest and to provide adequate circulation for prolonged periods of time allowing for transport of patie ...

DESCRIPTION (provided by applicant): Despite advances in the treatment of patients with sepsis, sepsis remains the second most common cause of death in non-coronary intensive care units and the tenth leading cause of death overall in high-income countries. It has been estimated that gt750,000 cases of severe sepsis occur annually in the United States, with a hospital mortality rate of ~35%. This n ...

DESCRIPTION (provided by applicant): This project will develop a social support assistant (SSA) for patients in the early stages of Alzheimer's disease (AD). The proposed system consists of a wearable face recognition (FR) device and a consumer Bluetooth-enabled wristwatch. It uses FR technology to identify people and provides social assistance via real-time reminders, such as names and relationsh ...

DESCRIPTION (provided by applicant): This project will develop a digital wireless streaming stereo audio system for the hearing impaired. Phase I has successfully demonstrated a novel technology that can be integrated fully into modern behind-the-ear hearing aids to receive audio from consumer electronics devices such as cell phones, televisions, stereos, and personal media devices. The system use ...

DESCRIPTION (provided by applicant): AME proposes to develop and build a multi-channel wideband neuro-recorder headstage that can be used for measuring and recording action potentials in mice. The neuro-recorder will use miniature flash-based memory to store data locally and transfer them to a PC post-testing. Currently available neuro-recording headstages only record local field potentials on mic ...

DESCRIPTION (provided by applicant): Current treatment of solid tumors is limited by normal tissue tolerance, inherent tumor resistance to radiation or chemotherapy, and toxicity from systemic administration of antineoplastic agents. The result is a narrow therapeutic index for most current chemotherapeutic agents. Our long term goal is to overcome these limitations by developing a targeted therap ...

DESCRIPTION (provided by applicant): Energy imbalance is a major health problem in the US that is related to poor quality of life and increases the risk of several diseases, including coronary heart disease, cancer and diabetes. Room respiration calorimeters are the standard for long-term and high resolution measurements of energy expenditure and substrate oxidation. Yet, room calorimeters aren't ...

DESCRIPTION (provided by applicant): Poison ivy/oak contact dermatitis is the most prevalent skin allergy in the United States, affecting gt50% of the adult population. The condition is the major cause of occupational hazard among outdoor workers in forestry, agriculture and firefighting, resulting in significant medical expenses and workers disability. Attempts have been made to provide prophyla ...

DESCRIPTION (provided by applicant): Peripheral artery disease and trauma are leading causes of morbidity and amputation in the United States. Recent advances in biomaterials provide for potential development of small diameter vascular grafts as a life-saving treatment. Development of a life-long graft (lt 6 mm id) requires a construct that will not cause significant blood clotting/thrombosis and ...

DESCRIPTION (provided by applicant): Despite recent advances, development of nucleic acid (NA) therapies continues to be impeded by the challenges of effective delivery. GeneSegues, Inc. (GSI) has developed a nonviral delivery technology, sub-50 nanometer (s50) capsules, which co-opt the raft/caveolar uptake path for efficient intracellular delivery of NA drugs. The raft/caveolar path is an endoge ...