Award Data

Improved cladding materials are needed for better structural stability in the corrosive high-pressure, hot-water environment of light water reactors, not only to extend fuel rod lifetime and increase fuel utilization (i.e., burn-up), but also to stave off run- away, active oxidation and melting of the rods under loss of coolant conditions. Proposed program will develop the use of a ceramic adhes ...

DESCRIPTION (provided by applicant). Several leading authorities, including the World Health Organization (WHO) and the U.S. Department of Health and Human Services (DHHS), have identified asthma as a priority disease area, and have called for action to reduce chronic disability and premature death due to asthma, to enhance HRQOL through education and improved asthma management techniques, and to ...

DESCRIPTION (provided by applicant): The annual healthcare costs of heavy drinking in the U.S. are estimated to be 24.6 billion (Bouchery et al., 2011). Effectively intervening with hazardous, risky, and problem drinkers would reduce both their morbidityand their healthcare costs. One way to address the needs of problem drinkers is by screening for and intervening with them in primary care. It is ...

DESCRIPTION (provided by applicant): This proposed project is motivated by the fact that comprehensive, broad-scale screening for eye diseases such as age-related macular degeneration (AMD), glaucoma, and diabetic retinopathy (DR), including advanced stages, is economically prohibitive without the introduction of computer-assisted diagnosis of retinal images. According to the CDC approximately 80 ...

Mesa Photonics plans development of a remote sensor to be used to detect clandestine nuclear material processing. We have identified a volatile chemical that is indicative of key steps in uranium isotope enrichment, and can be detected readily at low concentrations using optical methods. Small plumes that are about 1 m across and containing as little as 20 parts per million (ppm), or less, of th ...

DESCRIPTION (provided by applicant): The goal of this new SBIR program is to produce a combined clotting Factor VIII replacement and immunomodulatory therapy that will provide FVIII-specific tolerance induction at therapeutic doses for Hemophilia A patients. Hemophiliacs with lt 1% functional FVIII are classified as severe and must receive regular doses of replacement factor. A major issue with su ...

We are improving critical technologies needed for the development of laser-driven, table-top ultrafast x-ray sources suitable for ultrafast characterization of transient structures of energized molecules undergoing dissociation, isomerization, or intramolecular energy redistribution. In this SBIR project, Mesa Photonics will develop an X-ray ultrafast laser pulse measurement instrument for complet ...

DESCRIPTION (provided by applicant): The objective of this Phase II competitive renewal project is to implement a clinical study to collect data to validate EyeStar(tm), a software system as the basis for comprehensive telescreening for all stages of diabetic retinopathy (DR). According to the CDC, approximately 80 million people in the U.S. have some form of eye disease, including 20 million dia ...

DESCRIPTION (provided by applicant): Juvenile crime imposes enormous costs on victims, on society, and on juvenile offenders themselves. However, research assessing the efficacy of interventions for young offenders show, on average, only small effects on recidivism, substance abuse, and other behavioral outcomes. A major problem with existing interventions is that they tend to neglect individual d ...

DESCRIPTION (provided by applicant): Vision Quest Biomedical and the University of New Mexico (UNM) Health Science Center have assembled a team of inter-disciplinary scientists with experience in congenital heart disease diagnosis, ultrasoundimage analysis, and 3D ultrasound reconstruction. This team will develop and test a system to provide 3D multi-view reconstruction for improved ...