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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. A Preclinical Trial of Therapeutic Angiogenesis Plus Angioplasty and Stenting for Renal Vascular Disease

    SBC: Leflore Technologies LLC            Topic: 400

    Abstract Chronic kidney disease CKD is a progressive disorder affecting almost of the general population and this disease has shown a relentless growth over the past decades Patients with CKD have higher rates of hospitalization greater mortality shorter life expectancy and their healthcare costs are up to times more expensive than non CKD patients Thus treatments to slow halt ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  2. Multi Scale In Vitro D Tissue Model of Vascularized Bone Cartilage Interactions

    SBC: CFD Research Corporation            Topic: NIAMS

    Abstract Current in vitro models of vascularized bone tissues do not mimic the in vivo microenvironment comprising of diverse cell types in communication with each other through stromal barriers In addition they are hampered by lack of real time visualization and quantitation of vasculature bone as well as bone cartilage interactions In contrast animal models while providing useful information ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  3. Humanized Kidney Cellular Toxicity Platforms

    SBC: DISCOVERYBIOMED, INC.            Topic: NIEHS

    Principal Investigators for Small Business DiscoveryBioMed Inc DBM Project Summary Abstract The over arching goal of this proposed SBIR driven program is to create relevant DiscoveryBioMed DBM human cellular toxicity HCT platforms for the kidney grown in D and in D cell culture formats for a new gold standard in lead therapeutic asset and materials in vitro testing and to reduce marke ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  4. Coating to enhance endothelialization after left atrial appendage closure

    SBC: ENDOMIMETICS, LLC            Topic: NHLBI

    The prevalence of atrial fibrillation in the US is approximately to million putting patients at significantly increased risk of cardioembolic stroke Approximately of all strokes are caused by atrial fibrillation Most atrial fibrillation is treated with blood thinners however some patients are at such high risk of bleeding that it prohibits anticoagulation Left atrial appendage ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  5. Novel Mitochondrial DNA Repair Enzyme for Heart Failure

    SBC: EXSCIEN CORPORATION            Topic: NHLBI

    ABSTRACT Previous studies have demonstrated that heart failure triggers and sustains increases in oxidative stress inducing mitochondrial DNA mtDNA damage that then propagates myocardial injury resulting in cardiac dysfunction and myocardial cell death Fortunately mtDNA injury is reparable via endogenous base excision repair BER mechanisms The rate limiting step within BER is the amount of ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  6. ESTABLISHMENT OF D HUMAN TISSUE CULTURE MODEL SYSTEM FOR ADVANCING BREAST CANCER

    SBC: Tatva Biosciences, LLC            Topic: NCI

    Despite the recognition of obvious breast cancer BC racial health disparity we have failed to reduce the BC outcome gaps in African American women Unavailability of three dimensional D tissue culture model systems that mimics the original tumor s architecture and molecular characteristics of the racially disparate breast tumors limits our advancement in this area The overall goal of this S ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  7. SMARTPLATE TECHNOLOGY FOR ADVANCED CELLULAR STAC M

    SBC: CFD Research Corporation            Topic: NIDA

    This project will develop design fabricate test and demonstrate a novel SmartPlate Technology for Advanced Cell based Models STAC M The STAC M technology will be demonstrated for both current static culture and next generation cell based assays The proposed effort features a collaboration between CFD Research Corporation and Vanderbilt University and builds on several critical element ...

    SBIR Phase II 2017 Department of Health and Human ServicesNational Institutes of Health
  8. Development of a Non adjuvanted VLP Vaccine against Stealth H N Influenza

    SBC: EPIVAX, INC.            Topic: NIAID

    DESCRIPTION provided by applicant The avian origin H N influenza virus that emerged in humans in China in presents a unique challenge to vaccine development because it is poorly immunogenic Neutralizing antibodies are not detected in acute phase infection Anti H antibody responses are significantly delayed and exhibit low avidity in comparison with antibodies generated following seas ...

    SBIR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  9. A mechanism based computational tool to optimize pulmonary drug delivery

    SBC: CFD Research Corporation            Topic: 300

    DESCRIPTION provided by applicant Pulmonary drug delivery has emerged as a noninvasive alternative route for the treatment of lung diseases asthma COPD CF and lung cancer In order to obtain the desired level of effectiveness and safety of the inhaled drugs an appropriate deposition on the targeted region and subsequent absorption in the targeted region is vital Multiscale multidisciplin ...

    SBIR Phase II 2016 Department of Health and Human ServicesNational Institutes of Health
  10. Macromolecule Crystallization Screening Results Analysis

    SBC: IXPRESSGENES, INC.            Topic: 100

    Project Summary Crystallization followed by subsequent structure determination is a major step in understanding the structure function relationship of macromolecules Understanding macromolecule structure has become a key part in the development of new pharmaceuticals and is a major area of NIH research Crystallization however is also the rate limiting step despite technological efforts to a ...

    STTR Phase II 2016 Department of Health and Human ServicesNational Institutes of Health

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