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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Stable Gene Transfer by RNA Delivery

    SBC: B-MoGen Biotechnologies Inc            Topic: NHLBI

    Abstract Non viral gene delivery is used in most biomedical laboratories for basic research and for many commercial and medical applications These include basic investigations into gene function modification of cells for the production of recombinant proteins and generation of genetically modified human cells for cancer therapy e g chimeric antigen receptor transgenic T cells However the d ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  2. A Preclinical Trial of Therapeutic Angiogenesis Plus Angioplasty and Stenting for Renal Vascular Disease

    SBC: Leflore Technologies LLC            Topic: 400

    Abstract Chronic kidney disease CKD is a progressive disorder affecting almost of the general population and this disease has shown a relentless growth over the past decades Patients with CKD have higher rates of hospitalization greater mortality shorter life expectancy and their healthcare costs are up to times more expensive than non CKD patients Thus treatments to slow halt ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  3. Wireless System for Ambulatory Rodents to Measure Pressure and Volume in the Left Ventricle

    SBC: KORONIS BIOMEDICAL TECHNOLOGIES CORP.            Topic: NHLBI

    Abstract In this Phase I SBIR Koronis Biomedical Technologies proposes to develop and evaluate a fully implantable wireless device that monitors left ventricular pressure and volume P V in rodent studies Transgenic models of heart disease have been created through hypothesis driven research on rodents that seeks to both identify mechanistic pathways in academic research and support the develop ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  4. Object Finder for a Retinal Prosthesis

    SBC: Minnesota HealthSolutions Corporation            Topic: W

    Project Summary Abstract We propose to develop and evaluate the utility of advanced object recognition algorithms to control the information provided to retinal prosthetic patients Retinal prostheses restore partial vision to people blinded by outer retinal degenerative diseases such as retinitis pigmentosa RP or macular degeneration The Argus II retinal prosthesis system is intended to provid ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  5. Portable Low Cost Pulmonary Forced Oscillation Technique Instrument Using a Novel Sensor Design

    SBC: KORONIS BIOMEDICAL TECHNOLOGIES CORP.            Topic: NHLBI

    Abstract Koronis Biomedical Technologies and its collaborators propose to develop and fully test a low cost portable respiratory assessment device using the forced oscillation technique FOT leveraging the development of a new flexible thin film airflow sensor technology The proposed FOT device requires zero skill for the subject and operator making it ideal for occupational health screening p ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  6. Improved preparation of cell suspensions for single cell genomics

    SBC: SynderBio Inc.            Topic: 172

    Summary Single cell sequencing SCS is a disruptive new technology that offers an unprecedented ability to interrogate the genomics DNA RNA of single cells to understand the complex biologies of normal and diseased tissues SCS is not only important for basic research but also represents a next generation of diagnostic approaches particularly for cancer While multiple SCS platforms have bee ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  7. Improved detection of bladder cancer recurrence using a biophysical biomarker

    SBC: SynderBio Inc.            Topic: 102

    Bladder cancer is the fifth most commonly diagnosed cancer in the United States Three quarters of the nearly men and women diagnosed with bladder cancer just this year will have a less aggressive form of the disease which after treatment will require frequent visits to the urologist for invasive painful cystoscopy procedures for the remainder of their lifetimes to determine if the cance ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  8. Self crosslinkable hydrogel as an embolic agent for traumatic hemorrhage control

    SBC: Embomedics, Inc.            Topic: 300

    ABSTRACT Trauma is the th leading cause of morbidity and mortality after heart disease malignancies and lower respiratory illnesses in the United States Blunt abdominal trauma BAT is commonly caused by vehicular accidents and falls Uncontrolled bleeding is a major factor in early mortality after trauma contributing to to of trauma related deaths Transcatheter arterial embolization ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  9. Using Technology to Optimize Child Mental Health Care In Real World Settings

    SBC: Minnesota HealthSolutions Corporation            Topic: 104

    Minnesota HealthSolutions MHS in conjunction with Mayo Clinic of Rochester proposes the current project to address the NIMH DSIR priority to develop novel tools for the dissemination and implementation of evidence based treatment EBT We propose to develop a web and mobile based platform eChildPsych which integrates assessment treatment tools progress monitoring and reporting This susta ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  10. Vastly improved influenza diagnostics through the development of a handheld thermal contrast reader

    SBC: Vigilant Diagnostics, LLC            Topic: 600

    VIGILANT DIAGNOSTICS NIAID NIH STTR Phase I Application Vastly improved influenza diagnostics through the development of a portable thermal contrast reader PROJECT SUMMARY ABSTRACT Despite recent advances in rapid influenza diagnostic tests false negatives stemming from poor sensitivity contribute to nosocomial transmission and prevent thousands from receiving appropriate antiviral treatment A ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health

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